SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2axq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 402
THR A 403
ILE A  72
LEU A  42
GLY A 396
 None
 1.05A 1b02A-2axqA:
undetectable		 1b02A-2axqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  21
GLY A 123
ILE A 122
VAL A  17
 None
 0.77A 1d4sB-2axqA:
undetectable		 1d4sB-2axqA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 182
GLU A 252
ALA A 204
LEU A 202
 None
 1.16A 1etb1-2axqA:
undetectable		 1etb1-2axqA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 404
ILE A  72
THR A 117
 None
 0.82A 1rx3A-2axqA:
undetectable		 1rx3A-2axqA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A  46
ASP A  19
SER A  48
GLN A  40
 None
 1.07A 2cmlC-2axqA:
undetectable		 2cmlC-2axqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A   8
ILE A  75
GLY A  11
LEU A  53
SER A  52
 None
 0.95A 2qmmA-2axqA:
3.3
2qmmB-2axqA:
3.3		 2qmmA-2axqA:
19.47
2qmmB-2axqA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 124
GLY A 123
PHE A 228
LEU A 231
VAL A  95
 None
 1.31A 2w8yA-2axqA:
undetectable		 2w8yA-2axqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 157
ASP A 355
ASP A 381
SER A 390
 None
 1.00A 3qj7A-2axqA:
undetectable
3qj7D-2axqA:
undetectable		 3qj7A-2axqA:
20.04
3qj7D-2axqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  50
THR A  30
VAL A  64
LEU A  61
LEU A   8
 None
 1.27A 3s79A-2axqA:
undetectable		 3s79A-2axqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 128
ILE A 122
ILE A 438
ALA A 402
GLU A 431
 None
 0.89A 3tmzA-2axqA:
undetectable		 3tmzA-2axqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  95
GLY A 123
ILE A 411
VAL A  13
LEU A  74
 None
 1.16A 3zosA-2axqA:
undetectable
3zosB-2axqA:
undetectable		 3zosA-2axqA:
20.84
3zosB-2axqA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 337
ARG A 176
ASP A 266
 None
 0.86A 4fzvA-2axqA:
4.2		 4fzvA-2axqA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 404
ILE A  72
THR A 117
 None
 0.81A 4gh8A-2axqA:
undetectable		 4gh8A-2axqA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 237
GLU A 236
ASP A 138
ILE A 137
 None
 0.90A 4kttD-2axqA:
undetectable		 4kttD-2axqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 301
GLY A 261
ASP A 266
ASP A 259
 None
 1.01A 4uckB-2axqA:
3.3		 4uckB-2axqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 133
THR A 136
GLU A 442
HIS A 361
 None
 1.22A 5ecnA-2axqA:
undetectable		 5ecnA-2axqA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 172
ALA A 392
ASP A 355
SER A 389
 None
 1.06A 5l5fY-2axqA:
undetectable
5l5fZ-2axqA:
undetectable		 5l5fY-2axqA:
18.43
5l5fZ-2axqA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A   8
ILE A  75
GLY A  11
LEU A  53
SER A  52
 None
 0.87A 5twjA-2axqA:
undetectable		 5twjA-2axqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU A   8
ILE A  75
GLY A  11
LEU A  53
SER A  52
 None
 0.90A 5twjB-2axqA:
undetectable		 5twjB-2axqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A   8
ILE A  75
GLY A  11
LEU A  53
SER A  52
 None
 0.86A 5twjD-2axqA:
undetectable		 5twjD-2axqA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  36
CYH A  33
GLN A  40
ALA A  43
 None
 0.99A 5xu8A-2axqA:
undetectable		 5xu8A-2axqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 337
ARG A 176
ASP A 266
 None
 0.70A 5zvgA-2axqA:
4.5		 5zvgA-2axqA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2axq SACCHAROPINE
DEHYDROGENASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 337
ARG A 176
ASP A 266
 None
 0.72A 5zvgB-2axqA:
3.7		 5zvgB-2axqA:
23.41