SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ay9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 11 ALA A 237
THR A 240
ILE A 252
GLY A  84
ALA A 104
 None
 0.84A 1b02A-2ay9A:
undetectable		 1b02A-2ay9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 4 ILE A  33
MET A 381
VAL A 409
GLY A 378
 None
 1.22A 1e06B-2ay9A:
undetectable		 1e06B-2ay9A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 ALA A 115
GLY A 268
THR A 105
LEU A 187
LEU A 220
 None
 0.91A 1jipA-2ay9A:
undetectable		 1jipA-2ay9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.84A 1rxcB-2ay9A:
undetectable		 1rxcB-2ay9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.84A 1rxcE-2ay9A:
undetectable		 1rxcE-2ay9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.81A 1rxcI-2ay9A:
undetectable		 1rxcI-2ay9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.85A 1rxcK-2ay9A:
undetectable		 1rxcK-2ay9A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 GLY A 231
GLY A 227
LEU A 323
LEU A 331
MET A 330
 None
 1.03A 1ya4A-2ay9A:
undetectable		 1ya4A-2ay9A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		3 / 3 HIS A  54
ILE A 305
LEU A 315
 None
 0.75A 2kceA-2ay9A:
undetectable		 2kceA-2ay9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 5 LEU A  35
ILE A 399
ILE A 387
GLY A 391
 None
 0.94A 3bufA-2ay9A:
undetectable		 3bufA-2ay9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 GLN A 226
LEU A  88
SER A 245
LEU A 271
THR A 102
 None
 1.36A 3fsuA-2ay9A:
2.4		 3fsuA-2ay9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 11 THR A  99
LEU A 271
ALA A 283
GLN A 284
THR A 105
 None
 1.35A 3qelA-2ay9A:
4.3
3qelB-2ay9A:
5.5		 3qelA-2ay9A:
25.27
3qelB-2ay9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 10 VAL A 326
PHE A 228
GLY A  38
PHE A 360
ASN A 194
 None
None
5PV  A 414 (-3.3A)
5PV  A 414 (-4.5A)
5PV  A 414 ( 3.3A)
 1.24A 3r6wA-2ay9A:
1.3
3r6wB-2ay9A:
3.0		 3r6wA-2ay9A:
20.84
3r6wB-2ay9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 11 ASN A 393
ILE A 397
GLY A 391
ALA A 390
VAL A 326
 None
 1.16A 3rukD-2ay9A:
undetectable		 3rukD-2ay9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 ASN A 259
PHE A 260
ILE A 221
ARG A 316
ILE A  87
 None
 1.48A 4djfA-2ay9A:
undetectable		 4djfA-2ay9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.88A 4e1vA-2ay9A:
undetectable		 4e1vA-2ay9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.88A 4e1vC-2ay9A:
undetectable		 4e1vC-2ay9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.88A 4e1vD-2ay9A:
undetectable		 4e1vD-2ay9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.85A 4e1vE-2ay9A:
undetectable		 4e1vE-2ay9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 THR A 105
GLY A  75
GLN A 284
MET A 287
 None
 0.85A 4e1vH-2ay9A:
undetectable		 4e1vH-2ay9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 GLY A 408
VAL A 407
PHE A 350
PHE A 352
 None
 0.77A 4fglD-2ay9A:
2.8		 4fglD-2ay9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 GLY A 408
VAL A 407
PHE A 350
PHE A 352
 None
 0.74A 4fglC-2ay9A:
3.5		 4fglC-2ay9A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 SER A 255
SER A 257
ASN A 259
GLY A 302
 PLP  A 413 (-2.7A)
PLP  A 413 (-2.6A)
None
None
 0.95A 4fo4A-2ay9A:
undetectable		 4fo4A-2ay9A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		3 / 3 LEU A 202
ASP A 230
ILE A 208
 None
 0.68A 4xi3D-2ay9A:
undetectable		 4xi3D-2ay9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 7 LEU A 392
LEU A 337
ALA A 401
ALA A 403
LEU A  35
 None
 1.21A 4z90F-2ay9A:
undetectable
4z90G-2ay9A:
undetectable
4z90H-2ay9A:
undetectable
4z90J-2ay9A:
undetectable		 4z90F-2ay9A:
22.28
4z90G-2ay9A:
22.28
4z90H-2ay9A:
22.28
4z90J-2ay9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 7 ILE A  49
VAL A  53
ILE A 305
GLU A 265
 None
 0.89A 4zzbC-2ay9A:
undetectable
4zzbD-2ay9A:
undetectable		 4zzbC-2ay9A:
22.63
4zzbD-2ay9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 THR A  99
LEU A 271
ALA A 283
GLN A 284
THR A 105
 None
 1.42A 5ewjC-2ay9A:
5.4
5ewjD-2ay9A:
5.3		 5ewjC-2ay9A:
23.39
5ewjD-2ay9A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 GLY A 239
GLY A 190
ILE A 252
ASN A 199
LEU A 233
 None
 1.13A 5fa8A-2ay9A:
undetectable		 5fa8A-2ay9A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		5 / 12 GLY A 108
VAL A 309
VAL A  53
GLY A 261
ILE A 262
 PLP  A 413 (-3.5A)
None
None
None
None
 1.04A 5vopA-2ay9A:
2.6		 5vopA-2ay9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 8 VAL A 168
ASP A 169
HIS A 193
LEU A 177
 None
 0.85A 5w3jB-2ay9A:
undetectable		 5w3jB-2ay9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE
(Paracoccus
denitrificans) 		4 / 6 GLY A 107
THR A 105
GLN A 114
TYR A 295
 PLP  A 413 (-3.5A)
None
None
None
 1.30A 6ag0A-2ay9A:
undetectable		 6ag0A-2ay9A:
12.23