SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2aye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2aye REGULATORY PROTEIN
E2
(Alphapapillomavi
rus
10) 		5 / 11 ILE A 350
PHE A 299
SER A 314
ILE A 313
THR A 353
 None
 1.10A 2blaA-2ayeA:
undetectable		 2blaA-2ayeA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2aye REGULATORY PROTEIN
E2
(Alphapapillomavi
rus
10) 		5 / 11 ILE A 350
PHE A 299
SER A 314
ILE A 313
THR A 353
 None
 1.11A 3qg2B-2ayeA:
undetectable		 3qg2B-2ayeA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2aye REGULATORY PROTEIN
E2
(Alphapapillomavi
rus
10) 		5 / 11 ILE A 350
PHE A 299
SER A 314
ILE A 313
THR A 353
 None
 1.12A 4p68A-2ayeA:
undetectable		 4p68A-2ayeA:
18.87