SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ayn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		5 / 12 LEU A 285
GLY A 480
TYR A 479
ILE A 325
THR A 424
 None
 1.09A 1p91B-2aynA:
undetectable		 1p91B-2aynA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 7 GLY A 105
GLN A 120
ILE A 169
PRO A 171
 None
 1.08A 1rxcF-2aynA:
undetectable		 1rxcF-2aynA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 6 LEU A 319
ASN A 413
LEU A 478
LEU A 352
 None
 0.91A 1z95A-2aynA:
undetectable		 1z95A-2aynA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		5 / 12 ALA A 131
ALA A 321
ALA A 406
ILE A 217
PHE A 405
 None
 1.07A 2nyrA-2aynA:
undetectable		 2nyrA-2aynA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 5 LEU A 155
LEU A 174
LEU A 109
MET A 206
 None
 1.07A 2oaxF-2aynA:
undetectable		 2oaxF-2aynA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		5 / 12 LEU A 319
LEU A 323
ARG A 370
LEU A 285
PRO A 349
 None
 1.29A 2qd4A-2aynA:
undetectable		 2qd4A-2aynA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		5 / 12 LEU A 319
LEU A 323
ARG A 370
LEU A 285
PRO A 349
 None
 1.10A 2qd4B-2aynA:
undetectable		 2qd4B-2aynA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		3 / 3 GLN A 300
THR A 298
ASN A 307
 None
 0.90A 3v4tE-2aynA:
undetectable		 3v4tE-2aynA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		3 / 3 TRP A 471
TRP A 438
THR A 424
 None
 1.00A 4bboB-2aynA:
undetectable		 4bboB-2aynA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		5 / 8 ASP A 198
TYR A 435
SER A 430
GLY A 427
ALA A 474
 None
 1.18A 4m48A-2aynA:
undetectable		 4m48A-2aynA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 7 LEU A 319
ASN A 413
LEU A 478
LEU A 352
 None
 0.98A 4okwA-2aynA:
undetectable		 4okwA-2aynA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		3 / 3 MET A 180
MET A 206
TYR A 150
 None
 1.26A 4p6xI-2aynA:
undetectable		 4p6xI-2aynA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		3 / 3 LEU A 214
ASP A 243
ILE A 151
 None
 0.55A 4xi3D-2aynA:
undetectable		 4xi3D-2aynA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 6 ILE A 169
PRO A 171
HIS A 179
ILE A 151
 None
 0.98A 4zj8A-2aynA:
undetectable		 4zj8A-2aynA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 4 ASN A 339
ILE A 473
TYR A 475
PHE A 277
 None
 1.19A 5igvA-2aynA:
undetectable		 5igvA-2aynA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 8 GLY A 105
LEU A 106
ASN A 116
PHE A 449
 None
 0.43A 5xu8A-2aynA:
30.3		 5xu8A-2aynA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 8 GLY A 105
LEU A 106
GLN A 120
PHE A 449
 None
 0.70A 5xu8A-2aynA:
30.3		 5xu8A-2aynA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 8 LEU A 350
LEU A 419
GLY A 467
ARG A 329
 None
 0.92A 6ce2A-2aynA:
undetectable		 6ce2A-2aynA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens) 		4 / 5 ASN A 108
GLY A 427
HIS A 434
ASP A 450
 None
 0.45A 6gh9A-2aynA:
26.6		 6gh9A-2aynA:
13.49