SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ayu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 216
ARG A 234
ILE A 247
 None
 0.77A 1a4gB-2ayuA:
undetectable		 1a4gB-2ayuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.05A 1m8eB-2ayuA:
undetectable		 1m8eB-2ayuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 221
GLU A 121
TYR A 254
PRO A 227
 None
 1.19A 1mclA-2ayuA:
0.0
1mclB-2ayuA:
0.0
1mclP-2ayuA:
undetectable		 1mclA-2ayuA:
18.78
1mclB-2ayuA:
18.78
1mclP-2ayuA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 0.98A 1nodB-2ayuA:
undetectable		 1nodB-2ayuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 0.90A 1qomA-2ayuA:
undetectable		 1qomA-2ayuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 341
PHE A 315
LEU A 348
THR A 202
 None
 1.03A 1rmtD-2ayuA:
undetectable		 1rmtD-2ayuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 190
LEU A 196
VAL A 199
ILE A 344
LEU A 231
 None
 1.06A 1s19A-2ayuA:
undetectable		 1s19A-2ayuA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 233
LEU A 193
PHE A 316
SER A 311
 None
 1.25A 1wrkB-2ayuA:
undetectable		 1wrkB-2ayuA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 267
PHE A 253
THR A 251
GLU A 270
 None
 1.32A 2dttB-2ayuA:
undetectable
2dttC-2ayuA:
undetectable		 2dttB-2ayuA:
15.11
2dttC-2ayuA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.01A 2nodB-2ayuA:
undetectable		 2nodB-2ayuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 356
LEU A 193
ILE A 217
VAL A 199
ILE A 198
 None
 1.48A 2uxpA-2ayuA:
undetectable		 2uxpA-2ayuA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.37A 2y69C-2ayuA:
undetectable
2y69J-2ayuA:
undetectable		 2y69C-2ayuA:
19.07
2y69J-2ayuA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.36A 3ag3C-2ayuA:
undetectable
3ag3J-2ayuA:
undetectable		 3ag3C-2ayuA:
19.07
3ag3J-2ayuA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.09A 3e68A-2ayuA:
undetectable		 3e68A-2ayuA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.02A 3e6tB-2ayuA:
undetectable		 3e6tB-2ayuA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 0.86A 3e7iB-2ayuA:
undetectable		 3e7iB-2ayuA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 232
THR A 251
GLU A 220
ASN A 122
GLY A 228
 None
 1.25A 3g1uA-2ayuA:
undetectable		 3g1uA-2ayuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 1.03A 3nw2A-2ayuA:
undetectable		 3nw2A-2ayuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 355
ILE A 131
TRP A 132
 None
 0.94A 3nw2B-2ayuA:
undetectable		 3nw2B-2ayuA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 254
THR A 251
TYR A 266
TYR A 252
 None
 1.27A 3wipG-2ayuA:
undetectable
3wipH-2ayuA:
undetectable		 3wipG-2ayuA:
19.52
3wipH-2ayuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 254
THR A 251
TYR A 266
TYR A 252
 None
 1.28A 3wipF-2ayuA:
undetectable
3wipJ-2ayuA:
undetectable		 3wipF-2ayuA:
19.52
3wipJ-2ayuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 314
VAL A 283
THR A 202
ILE A 203
 None
 1.33A 4retA-2ayuA:
undetectable		 4retA-2ayuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 ASN A 314
VAL A 283
THR A 202
ILE A 203
 None
 1.33A 4retC-2ayuA:
undetectable		 4retC-2ayuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 266
LEU A 222
GLY A 228
PHE A 253
 None
 0.73A 5kmdC-2ayuA:
undetectable
5kmdD-2ayuA:
undetectable		 5kmdC-2ayuA:
19.01
5kmdD-2ayuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.34A 5wauC-2ayuA:
undetectable
5wauJ-2ayuA:
undetectable		 5wauC-2ayuA:
19.07
5wauJ-2ayuA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ayu NUCLEOSOME ASSEMBLY
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 242
PHE A 243
LEU A 248
PHE A 316
 None
 1.35A 5wauc-2ayuA:
undetectable
5wauj-2ayuA:
undetectable		 5wauc-2ayuA:
19.07
5wauj-2ayuA:
8.31