SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ayv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2
(Toxoplasma
gondii) 		5 / 12 THR A  98
ILE A  54
ALA A  23
THR A  36
ILE A  37
 UNX  A 153 ( 4.0A)
None
None
None
None
 1.25A 3ddyA-2ayvA:
undetectable		 3ddyA-2ayvA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2
(Toxoplasma
gondii) 		5 / 12 LEU A  89
ILE A   6
ILE A  99
VAL A 102
LEU A 103
 None
None
UNX  A 153 (-4.9A)
None
None
 1.03A 3w68D-2ayvA:
undetectable		 3w68D-2ayvA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2
(Toxoplasma
gondii) 		5 / 12 GLY A  82
LEU A 119
ILE A 106
ASN A  53
VAL A  67
 None
UNX  A 154 (-4.9A)
None
None
None
 0.99A 4fr0A-2ayvA:
undetectable		 4fr0A-2ayvA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2
(Toxoplasma
gondii) 		5 / 11 ILE A 106
ILE A  99
ILE A  37
ALA A  23
VAL A  67
 None
UNX  A 153 (-4.9A)
None
None
None
 1.01A 4h1nA-2ayvA:
undetectable		 4h1nA-2ayvA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ayv UBIQUITIN-CONJUGATIN
G ENZYME E2
(Toxoplasma
gondii) 		3 / 3 ILE A  84
VAL A  67
PRO A  65
 None
 0.62A 5uunA-2ayvA:
undetectable		 5uunA-2ayvA:
17.94