SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ayx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		5 / 12 SER A 946
ASP A 870
TYR A 939
LEU A 864
LEU A 895
 None
 1.46A 1p33A-2ayxA:
5.4		 1p33A-2ayxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		5 / 12 ALA A 787
ARG A 767
LEU A 718
ALA A 786
VAL A 746
 None
 1.03A 1xdkA-2ayxA:
undetectable		 1xdkA-2ayxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		5 / 12 ALA A 787
ARG A 767
LEU A 718
ALA A 786
VAL A 746
 None
 1.04A 1xdkE-2ayxA:
undetectable		 1xdkE-2ayxA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 7 GLY A 883
PRO A 879
ASP A 832
THR A 903
 None
 1.13A 2aouB-2ayxA:
2.5		 2aouB-2ayxA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 7 LEU A 726
LEU A 722
PRO A 808
GLU A 802
 None
 1.05A 2jn3A-2ayxA:
undetectable		 2jn3A-2ayxA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		3 / 3 MET A 878
VAL A 829
GLU A 702
 None
 0.88A 2x9gA-2ayxA:
4.9		 2x9gA-2ayxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 6 VAL A 763
ILE A 798
ILE A 748
LEU A 747
 None
 0.81A 3hegA-2ayxA:
undetectable		 3hegA-2ayxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 6 GLY A 901
VAL A 876
SER A 874
THR A 903
 None
 0.95A 3tj7A-2ayxA:
undetectable
3tj7B-2ayxA:
undetectable		 3tj7A-2ayxA:
20.15
3tj7B-2ayxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 6 GLY A 901
VAL A 876
SER A 874
THR A 903
 None
 0.94A 3tj7C-2ayxA:
undetectable
3tj7D-2ayxA:
undetectable		 3tj7C-2ayxA:
20.15
3tj7D-2ayxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 6 VAL A 876
SER A 874
THR A 903
GLY A 901
 None
 0.95A 3tj7C-2ayxA:
undetectable
3tj7D-2ayxA:
undetectable		 3tj7C-2ayxA:
20.15
3tj7D-2ayxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		5 / 12 LEU A 936
LEU A 847
ILE A 900
SER A 846
VAL A 927
 None
 1.25A 4f4dB-2ayxA:
3.1		 4f4dB-2ayxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 6 ALA A 716
ASN A 715
ASP A 750
GLU A 751
 None
 1.02A 4g24A-2ayxA:
undetectable		 4g24A-2ayxA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		4 / 7 ASP A 859
LEU A 828
ASN A 867
LEU A 800
 None
 0.85A 4ib4A-2ayxA:
undetectable		 4ib4A-2ayxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 2ayx SENSOR KINASE
PROTEIN RCSC
(Escherichia
coli) 		5 / 10 PRO A 834
ARG A 837
HIS A 833
THR A 742
ALA A 841
 None
 1.23A 5vyhA-2ayxA:
undetectable		 5vyhA-2ayxA:
20.78