SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ayz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_B_SAMB1293_0 (GLYCINE N-METHYLTRANSFERASE)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 12	ILE A 890 GLY A 901 VAL A 872 ALA A 904 GLY A 857	None	1.23A	1kiaB-2ayzA: 3.0	1kiaB-2ayzA: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OUZ_A_C3DA999_0 (ESTROGEN RECEPTOR)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 12	THR A 935 LEU A 929 LEU A 844 LEU A 847 LEU A 873	None	1.06A	2ouzA-2ayzA: undetectable	2ouzA-2ayzA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_A_IBPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 10	VAL A 899 LEU A 897 GLY A 857 ALA A 860 SER A 874	None	1.11A	4ph9A-2ayzA: undetectable	4ph9A-2ayzA: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PH9_B_IBPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 10	VAL A 899 LEU A 897 GLY A 857 ALA A 860 SER A 874	None	1.11A	4ph9B-2ayzA: undetectable	4ph9B-2ayzA: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_B_LOCB502_2 (TUBULIN BETA CHAIN)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 12	LYS A 866 LEU A 864 VAL A 830 LYS A 852 ALA A 854	None	1.19A	4x1iB-2ayzA: 4.1	4x1iB-2ayzA: 13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XTA_A_DIFA501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	4 / 9	SER A 874 ALA A 860 LEU A 897 ILE A 871	None	0.94A	4xtaA-2ayzA: undetectable	4xtaA-2ayzA: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_A_FLPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 12	VAL A 899 LEU A 897 GLY A 857 ALA A 860 SER A 874	None	1.09A	5jvzA-2ayzA: undetectable	5jvzA-2ayzA: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_B_FLPB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	2ayz	SENSOR KINASE PROTEIN RCSC (Escherichia coli)	5 / 12	VAL A 899 LEU A 897 GLY A 857 ALA A 860 SER A 874	None	1.10A	5jvzB-2ayzA: undetectable	5jvzB-2ayzA: 13.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KIA_B_SAMB1293_0","GLYCINE N-METHYLTRANSFERASE","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"ILE A 890;GLY A 901;VAL A 872;ALA A 904;GLY A 857","None","1.23A","1kiaB-2ayzA:3.0","1kiaB-2ayzA:18.60"],["2OUZ_A_C3DA999_0","ESTROGEN RECEPTOR","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"THR A 935;LEU A 929;LEU A 844;LEU A 847;LEU A 873","None","1.06A","2ouzA-2ayzA:undetectable","2ouzA-2ayzA:21.92"],["4PH9_A_IBPA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"VAL A 899;LEU A 897;GLY A 857;ALA A 860;SER A 874","None","1.11A","4ph9A-2ayzA:undetectable","4ph9A-2ayzA:13.63"],["4PH9_B_IBPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"VAL A 899;LEU A 897;GLY A 857;ALA A 860;SER A 874","None","1.11A","4ph9B-2ayzA:undetectable","4ph9B-2ayzA:13.63"],["4X1I_B_LOCB502_2","TUBULIN BETA CHAIN","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"LYS A 866;LEU A 864;VAL A 830;LYS A 852;ALA A 854","None","1.19A","4x1iB-2ayzA:4.1","4x1iB-2ayzA:13.93"],["4XTA_A_DIFA501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",4,"SER A 874;ALA A 860;LEU A 897;ILE A 871","None","0.94A","4xtaA-2ayzA:undetectable","4xtaA-2ayzA:23.08"],["5JVZ_A_FLPA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"VAL A 899;LEU A 897;GLY A 857;ALA A 860;SER A 874","None","1.09A","5jvzA-2ayzA:undetectable","5jvzA-2ayzA:13.63"],["5JVZ_B_FLPB601_1","PROSTAGLANDIN G\/H SYNTHASE 2","2ayz","SENSOR KINASE PROTEIN RCSC","Escherichia coli",5,"VAL A 899;LEU A 897;GLY A 857;ALA A 860;SER A 874","None","1.10A","5jvzB-2ayzA:undetectable","5jvzB-2ayzA:13.63"]]