SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2az3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		3 / 3 TRP A  79
ALA A  76
VAL A  10
 None
 0.90A 1c4dA-2az3A:
undetectable
1c4dB-2az3A:
undetectable		 1c4dA-2az3A:
8.80
1c4dB-2az3A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		3 / 3 ALA A  76
VAL A  10
TRP A  79
 None
 0.94A 1c4dC-2az3A:
undetectable
1c4dD-2az3A:
undetectable		 1c4dC-2az3A:
8.80
1c4dD-2az3A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 8 HIS A 119
GLU A 132
HIS A  52
ALA A 128
 CDP  A1100 (-4.3A)
None
None
None
 0.64A 2bnnA-2az3A:
undetectable
2bnnB-2az3A:
undetectable		 2bnnA-2az3A:
21.67
2bnnB-2az3A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 6 TRP A 145
SER A 150
ALA A 151
ASP A 148
 None
 1.31A 3aruA-2az3A:
undetectable		 3aruA-2az3A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		5 / 8 GLY A  93
ALA A  94
ASP A  99
GLY A 110
LEU A 117
 None
 1.35A 3em6A-2az3A:
undetectable		 3em6A-2az3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 7 GLY A  20
ASP A  24
ILE A  25
VAL A  12
 None
 0.75A 3fi0E-2az3A:
undetectable		 3fi0E-2az3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 8 GLY A  20
ASP A  24
ILE A  25
VAL A  12
 None
 0.74A 3fi0G-2az3A:
undetectable		 3fi0G-2az3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 8 GLY A  20
ASP A  24
ILE A  25
VAL A  12
 None
 0.79A 3fi0I-2az3A:
undetectable		 3fi0I-2az3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 8 GLY A  20
ASP A  24
ILE A  25
VAL A  12
 None
 0.75A 3fi0Q-2az3A:
undetectable		 3fi0Q-2az3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		5 / 11 PHE A   9
ASN A 129
GLY A 120
GLY A  38
MET A  42
 None
 1.24A 4a6nC-2az3A:
0.0		 4a6nC-2az3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 7 ARG A 106
ILE A 118
ASN A 116
GLU A  55
 CDP  A1100 ( 4.8A)
None
CDP  A1100 (-3.1A)
MG  A 201 ( 2.7A)
 1.08A 4a97E-2az3A:
undetectable		 4a97E-2az3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		5 / 12 ARG A 106
ILE A 118
ASN A 116
GLU A  55
VAL A  10
 CDP  A1100 ( 4.8A)
None
CDP  A1100 (-3.1A)
MG  A 201 ( 2.7A)
None
 1.45A 4a97A-2az3A:
0.7
4a97B-2az3A:
0.7		 4a97A-2az3A:
18.30
4a97B-2az3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 8 ARG A 106
ILE A 118
ASN A 116
GLU A  55
 CDP  A1100 ( 4.8A)
None
CDP  A1100 (-3.1A)
MG  A 201 ( 2.7A)
 1.08A 4a97C-2az3A:
undetectable		 4a97C-2az3A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		5 / 8 ILE A  25
ASP A  24
ILE A  22
VAL A  74
SER A  71
 None
 1.26A 4ac9C-2az3A:
undetectable		 4ac9C-2az3A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 8 ILE A  22
LEU A  29
MET A  77
PHE A  75
 None
 0.99A 4r38B-2az3A:
undetectable		 4r38B-2az3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2az3 NUCLEOSIDE
DIPHOSPHATE KINASE
(Halobacterium
salinarum) 		4 / 4 GLY A  72
PRO A  73
VAL A  74
ARG A  43
 None
 1.37A 5uunA-2az3A:
0.0
5uunB-2az3A:
0.0		 5uunA-2az3A:
22.97
5uunB-2az3A:
22.97