SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2az4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 5 ASP A 189
HIS A 404
HIS A  92
HIS A  97
 ZN  A 602 ( 2.5A)
ZN  A 602 (-3.5A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.3A)
 1.02A 1ei6A-2az4A:
undetectable		 1ei6A-2az4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
HIS A  92
HIS A 167
TYR A 261
ASP A 168
 ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
None
None
 1.39A 1ituA-2az4A:
undetectable		 1ituA-2az4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
HIS A  92
HIS A 167
TYR A 261
ASP A 168
 ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
None
None
 1.39A 1ituB-2az4A:
undetectable		 1ituB-2az4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 LEU A  66
GLY A  20
VAL A  22
ILE A  23
ILE A 177
 None
 0.90A 1pbkA-2az4A:
undetectable		 1pbkA-2az4A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 6 TYR A 186
HIS A  97
PRO A 408
VAL A 218
 None
ZN  A 602 (-3.3A)
None
None
 1.20A 1q13A-2az4A:
undetectable		 1q13A-2az4A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 GLY A  20
TYR A 186
ILE A  23
HIS A  97
HIS A 404
 None
None
None
ZN  A 602 (-3.3A)
ZN  A 602 (-3.5A)
 1.40A 1tmxB-2az4A:
undetectable		 1tmxB-2az4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 11 ASP A  96
HIS A  97
HIS A 167
ASP A 189
HIS A 404
 ZN  A 602 (-2.8A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.5A)
 0.23A 2q0jB-2az4A:
11.2		 2q0jB-2az4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 LEU A 104
THR A  38
GLY A  37
GLY A  20
LEU A 110
 None
 1.12A 2uvnA-2az4A:
undetectable		 2uvnA-2az4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 10 HIS A  92
HIS A  94
ASP A  96
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.88A 4c1dB-2az4A:
10.8		 4c1dB-2az4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 11 HIS A  92
HIS A  94
ASP A  96
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.94A 4c1fA-2az4A:
12.0
4c1fB-2az4A:
11.8		 4c1fA-2az4A:
20.57
4c1fB-2az4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 9 HIS A  92
HIS A  94
ASP A  96
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.89A 4c1hA-2az4A:
12.6		 4c1hA-2az4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 10 ASP A 168
ALA A 169
HIS A 382
VAL A 165
HIS A  94
 None
None
None
None
ZN  A 601 (-3.4A)
 1.09A 4c5nB-2az4A:
undetectable		 4c5nB-2az4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 ILE A 119
LEU A  95
THR A 141
ILE A 101
LEU A  90
 None
 1.00A 4ej1B-2az4A:
undetectable		 4ej1B-2az4A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 8 HIS A  94
ASP A  96
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.84A 4exsB-2az4A:
11.1		 4exsB-2az4A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 PHE A 293
GLU A 282
ASN A 284
LEU A 123
ILE A 119
 None
 1.09A 4k39A-2az4A:
undetectable		 4k39A-2az4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 PHE A 293
GLU A 282
ASN A 284
SER A 122
LEU A 123
 None
 1.25A 4k39A-2az4A:
undetectable		 4k39A-2az4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 7 HIS A  97
HIS A 404
HIS A 382
HIS A 167
 ZN  A 602 (-3.3A)
ZN  A 602 (-3.5A)
None
ZN  A 601 (-3.4A)
 0.99A 4p6sB-2az4A:
undetectable		 4p6sB-2az4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
ILE A 403
HIS A 404
GLU A 216
LEU A 190
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.5A)
None
None
 1.32A 4r88B-2az4A:
undetectable		 4r88B-2az4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
ILE A 403
HIS A 404
GLU A 216
LEU A 190
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.5A)
None
None
 1.33A 4r88C-2az4A:
undetectable		 4r88C-2az4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
ILE A 403
HIS A 404
GLU A 216
LEU A 190
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.5A)
None
None
 1.29A 4r88D-2az4A:
undetectable		 4r88D-2az4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
ILE A 403
HIS A 404
GLU A 216
LEU A 190
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.5A)
None
None
 1.31A 4r88E-2az4A:
undetectable		 4r88E-2az4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
ILE A 403
HIS A 404
GLU A 216
LEU A 190
 ZN  A 602 (-3.3A)
None
ZN  A 602 (-3.5A)
None
None
 1.31A 4r88F-2az4A:
undetectable		 4r88F-2az4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 9 PHE A 258
LEU A 244
VAL A 297
VAL A 279
LEU A 289
 None
 1.27A 4wnvA-2az4A:
0.0		 4wnvA-2az4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 LEU A 212
GLY A 188
ALA A 207
VAL A  25
PHE A  34
 None
 1.09A 4wnwB-2az4A:
undetectable		 4wnwB-2az4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 8 HIS A  94
ASP A  96
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.83A 5a5zA-2az4A:
11.5		 5a5zA-2az4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		6 / 11 HIS A  92
HIS A  94
ASP A  96
HIS A  97
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.37A 5ayaA-2az4A:
12.5		 5ayaA-2az4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 12 HIS A  97
ASP A  96
LEU A 406
PHE A 222
ILE A  18
 ZN  A 602 (-3.3A)
ZN  A 602 (-2.8A)
None
None
None
 1.45A 5dv4A-2az4A:
2.5		 5dv4A-2az4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 5 VAL A  88
THR A  86
ASP A 105
LEU A  66
 None
 1.25A 5m0iB-2az4A:
undetectable		 5m0iB-2az4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		6 / 10 HIS A  92
HIS A  94
HIS A  97
ASP A 189
TYR A 261
HIS A 382
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.3A)
ZN  A 602 ( 2.5A)
None
None
 1.41A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		6 / 10 HIS A  92
HIS A  94
HIS A  97
HIS A 167
ASP A 189
HIS A 382
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.3A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
None
 0.27A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 10 HIS A  97
HIS A 404
HIS A  92
ASP A 189
HIS A 167
 ZN  A 602 (-3.3A)
ZN  A 602 (-3.5A)
ZN  A 601 (-3.4A)
ZN  A 602 ( 2.5A)
ZN  A 601 (-3.4A)
 1.13A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		5 / 10 HIS A 167
HIS A  92
HIS A 382
ASP A 189
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 601 (-3.4A)
None
ZN  A 602 ( 2.5A)
ZN  A 602 (-3.5A)
 1.09A 5nzwA-2az4A:
6.4		 5nzwA-2az4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		3 / 3 GLU A 237
HIS A 193
ARG A 197
 None
 0.96A 5uunA-2az4A:
undetectable		 5uunA-2az4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 7 HIS A 195
ASP A 168
GLY A 260
ASN A 264
 None
 1.15A 5x7pA-2az4A:
undetectable		 5x7pA-2az4A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 6 GLY A 260
TYR A 261
LEU A 281
VAL A 333
 None
 0.93A 5x80A-2az4A:
undetectable
5x80B-2az4A:
undetectable		 5x80A-2az4A:
18.42
5x80B-2az4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 8 HIS A  94
ASP A  96
HIS A  92
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.92A 5zj8A-2az4A:
11.1		 5zj8A-2az4A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2az4 HYPOTHETICAL PROTEIN
EF2904
(Enterococcus
faecalis) 		4 / 8 HIS A  94
ASP A  96
HIS A 167
HIS A 404
 ZN  A 601 (-3.4A)
ZN  A 602 (-2.8A)
ZN  A 601 (-3.4A)
ZN  A 602 (-3.5A)
 0.91A 5zj8A-2az4A:
11.1		 5zj8A-2az4A:
20.23