SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2azk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 ARG A  91
TYR A 111
ASP A  27
ASN A  25
 None
 1.11A 1rjdA-2azkA:
undetectable		 1rjdA-2azkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 ARG A  91
TYR A 111
ASP A  27
ASN A  25
 None
 1.12A 1rjdB-2azkA:
undetectable		 1rjdB-2azkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 ARG A  91
TYR A 111
ASP A  27
ASN A  25
 None
 1.14A 1rjdC-2azkA:
undetectable		 1rjdC-2azkA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 SER A  77
LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.80A 1rqjA-2azkA:
30.0		 1rqjA-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 SER A  77
LEU A  78
ASP A  81
THR A 161
GLN A 197
 None
 0.84A 1rqjA-2azkA:
30.0		 1rqjA-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 SER A  77
LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.73A 1rqjA-2azkA:
30.0		 1rqjA-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 SER A  77
LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.76A 1rqjB-2azkA:
29.8		 1rqjB-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 SER A  77
LEU A  78
ASP A  81
THR A 161
GLN A 197
 None
 0.79A 1rqjB-2azkA:
29.8		 1rqjB-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 SER A  77
LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.69A 1rqjB-2azkA:
29.8		 1rqjB-2azkA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.38A 1yhlA-2azkA:
24.5		 1yhlA-2azkA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.95A 1yhlA-2azkA:
24.5		 1yhlA-2azkA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.84A 1yhlA-2azkA:
24.5		 1yhlA-2azkA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.36A 1yq7A-2azkA:
23.0		 1yq7A-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 11 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.79A 1yq7A-2azkA:
23.0		 1yq7A-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.39A 1yv5A-2azkA:
22.7		 1yv5A-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.02A 1yv5A-2azkA:
22.7		 1yv5A-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.89A 1yv5A-2azkA:
22.7		 1yv5A-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.46A 1zw5A-2azkA:
23.3		 1zw5A-2azkA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 7 ALA A  55
TYR A 257
TYR A  64
PHE A   6
 None
 1.15A 2ajvH-2azkA:
undetectable
2ajvL-2azkA:
undetectable		 2ajvH-2azkA:
23.05
2ajvL-2azkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.04A 2e91A-2azkA:
18.7		 2e91A-2azkA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 2e91A-2azkA:
18.7		 2e91A-2azkA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.43A 2e91B-2azkA:
17.7		 2e91B-2azkA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.14A 2f89F-2azkA:
24.2		 2f89F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.45A 2f8cF-2azkA:
23.5		 2f8cF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.91A 2f8cF-2azkA:
23.5		 2f8cF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.98A 2f8cF-2azkA:
23.5		 2f8cF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.82A 2f8cF-2azkA:
23.5		 2f8cF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.07A 2f8zF-2azkA:
23.7		 2f8zF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.85A 2f8zF-2azkA:
23.7		 2f8zF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 2f94F-2azkA:
23.6		 2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.02A 2f94F-2azkA:
23.6		 2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
ASP A  81
THR A 139
THR A 161
GLN A 197
 None
 0.87A 2f94F-2azkA:
23.6		 2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.90A 2f94F-2azkA:
23.6		 2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
ASP A  85
THR A 139
THR A 161
GLN A 197
 None
 0.64A 2f94F-2azkA:
23.6		 2f94F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.47A 2f9kF-2azkA:
23.3		 2f9kF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.96A 2f9kF-2azkA:
23.3		 2f9kF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.06A 2f9kF-2azkA:
23.3		 2f9kF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.90A 2f9kF-2azkA:
23.3		 2f9kF-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.36A 2o1oA-2azkA:
23.8		 2o1oA-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.89A 2o1oA-2azkA:
23.8		 2o1oA-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 220
ASP A 201
GLN A 197
THR A 156
ASN A 150
 None
 1.33A 2o1oA-2azkA:
23.8		 2o1oA-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.40A 2o1oB-2azkA:
24.0		 2o1oB-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.88A 2o1oB-2azkA:
24.0		 2o1oB-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.67A 2o1oB-2azkA:
24.0		 2o1oB-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A 220
ASP A 201
GLN A 197
THR A 156
ASN A 150
 None
 1.30A 2o1oB-2azkA:
24.0		 2o1oB-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.43A 2q58A-2azkA:
11.6		 2q58A-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 201
 None
 0.73A 2q58A-2azkA:
11.6		 2q58A-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 201
 None
 0.80A 2q58A-2azkA:
11.6		 2q58A-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
THR A 161
GLN A 197
ASP A 201
 None
 0.90A 2q58A-2azkA:
11.6		 2q58A-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A 220
ASP A 201
GLN A 197
THR A 156
ASN A 150
 None
 1.39A 2q58A-2azkA:
11.6		 2q58A-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
GLN A 197
ASP A 200
 None
 1.49A 2qisA-2azkA:
23.3		 2qisA-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
GLN A 197
ASP A 200
 None
 0.94A 2qisA-2azkA:
23.3		 2qisA-2azkA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
 None
 1.20A 2vcvD-2azkA:
2.1		 2vcvD-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
 None
 1.20A 2vcvE-2azkA:
undetectable		 2vcvE-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
 None
 1.18A 2vcvH-2azkA:
1.7		 2vcvH-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A 186
LEU A 167
ALA A 173
LEU A 171
ALA A 128
 None
 1.20A 2vcvI-2azkA:
2.2		 2vcvI-2azkA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 8 PHE A 253
THR A 181
VAL A 188
LEU A  56
 None
 0.79A 2zujA-2azkA:
undetectable		 2zujA-2azkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		3 / 3 LEU A 192
TRP A   7
TYR A 196
 None
 0.92A 3aicH-2azkA:
undetectable		 3aicH-2azkA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.34A 3ez3A-2azkA:
23.3		 3ez3A-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.33A 3ez3A-2azkA:
23.3		 3ez3A-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.36A 3ez3C-2azkA:
23.4		 3ez3C-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.36A 3ez3C-2azkA:
23.4		 3ez3C-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.82A 3ez3D-2azkA:
23.1		 3ez3D-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.80A 3ez3D-2azkA:
23.1		 3ez3D-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.03A 3ibaA-2azkA:
24.1		 3ibaA-2azkA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.30A 3ibaA-2azkA:
24.1		 3ibaA-2azkA:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.34A 3ldwA-2azkA:
23.0		 3ldwA-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.34A 3ldwA-2azkA:
23.0		 3ldwA-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.45A 3ldwB-2azkA:
23.2		 3ldwB-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.39A 3ldwC-2azkA:
23.0		 3ldwC-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.38A 3ldwC-2azkA:
23.0		 3ldwC-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.43A 3ldwD-2azkA:
22.7		 3ldwD-2azkA:
29.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A 135
LEU A 186
SER A 172
THR A 181
 None
 0.91A 3lm8A-2azkA:
undetectable
3lm8C-2azkA:
undetectable		 3lm8A-2azkA:
21.52
3lm8C-2azkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 138
HIS A  74
LEU A 186
LEU A 135
 None
 0.96A 3lm8B-2azkA:
undetectable
3lm8D-2azkA:
undetectable		 3lm8B-2azkA:
21.52
3lm8D-2azkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 7 TYR A 191
ASN A 250
LEU A 247
LYS A 243
 None
 1.35A 3lslA-2azkA:
undetectable
3lslD-2azkA:
undetectable		 3lslA-2azkA:
23.45
3lslD-2azkA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 TYR A 191
ASN A 250
LEU A 247
LYS A 243
 None
 1.34A 3lslG-2azkA:
undetectable		 3lslG-2azkA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.45A 3n45F-2azkA:
23.8		 3n45F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.93A 3n45F-2azkA:
23.8		 3n45F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.01A 3n45F-2azkA:
23.8		 3n45F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.88A 3n45F-2azkA:
23.8		 3n45F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.45A 3n46F-2azkA:
23.2		 3n46F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
THR A 161
GLN A 197
ASP A 200
 None
 0.83A 3n46F-2azkA:
23.2		 3n46F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.98A 3n46F-2azkA:
23.2		 3n46F-2azkA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		3 / 3 TYR A 196
HIS A  74
ARG A  45
 None
 1.04A 4htfA-2azkA:
undetectable		 4htfA-2azkA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.41A 4kpdA-2azkA:
23.6		 4kpdA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.37A 4kpdA-2azkA:
23.6		 4kpdA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.03A 4kpdA-2azkA:
23.6		 4kpdA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.83A 4kpdA-2azkA:
23.6		 4kpdA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
THR A 161
GLN A 197
ASP A 200
 None
 0.67A 4kpdA-2azkA:
23.6		 4kpdA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.43A 4kpjA-2azkA:
22.7		 4kpjA-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.00A 4kpjA-2azkA:
22.7		 4kpjA-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.91A 4kpjA-2azkA:
22.7		 4kpjA-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.49A 4kq5A-2azkA:
22.8		 4kq5A-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.94A 4kq5A-2azkA:
22.8		 4kq5A-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.88A 4kq5A-2azkA:
22.8		 4kq5A-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.41A 4kqsA-2azkA:
23.7		 4kqsA-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.98A 4kqsA-2azkA:
23.7		 4kqsA-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.88A 4kqsA-2azkA:
23.7		 4kqsA-2azkA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.96A 4n9uA-2azkA:
23.1		 4n9uA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
THR A 139
THR A 161
GLN A 197
 None
 0.89A 4n9uA-2azkA:
23.1		 4n9uA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.88A 4n9uA-2azkA:
23.1		 4n9uA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
THR A 139
THR A 161
GLN A 197
 None
 0.77A 4n9uA-2azkA:
23.1		 4n9uA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.04A 4ng6A-2azkA:
22.8		 4ng6A-2azkA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
ASP A  81
THR A 139
THR A 161
GLN A 197
 None
 0.96A 4ng6A-2azkA:
22.8		 4ng6A-2azkA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.82A 4ng6A-2azkA:
22.8		 4ng6A-2azkA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 4nkeA-2azkA:
22.9		 4nkeA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.04A 4nkeA-2azkA:
22.9		 4nkeA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.89A 4nkeA-2azkA:
22.9		 4nkeA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 4nkfA-2azkA:
23.2		 4nkfA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.98A 4nkfA-2azkA:
23.2		 4nkfA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.88A 4nkfA-2azkA:
23.2		 4nkfA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 4nuaA-2azkA:
23.1		 4nuaA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.97A 4nuaA-2azkA:
23.1		 4nuaA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.88A 4nuaA-2azkA:
23.1		 4nuaA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.41A 4oguA-2azkA:
23.0		 4oguA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.99A 4oguA-2azkA:
23.0		 4oguA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 9 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.88A 4oguA-2azkA:
23.0		 4oguA-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.49A 4p0vA-2azkA:
23.6		 4p0vA-2azkA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 1.04A 4p0wA-2azkA:
24.1		 4p0wA-2azkA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 11 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.91A 4p0wA-2azkA:
24.1		 4p0wA-2azkA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
GLN A 197
ASP A 200
 None
 0.94A 4q23A-2azkA:
22.7		 4q23A-2azkA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.35A 4rxdA-2azkA:
23.0		 4rxdA-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.93A 4rxdA-2azkA:
23.0		 4rxdA-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.83A 4rxdA-2azkA:
23.0		 4rxdA-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.43A 4rxdB-2azkA:
23.3		 4rxdB-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.36A 4rxdB-2azkA:
23.3		 4rxdB-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.80A 4rxdB-2azkA:
23.3		 4rxdB-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.93A 4rxdB-2azkA:
23.3		 4rxdB-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.75A 4rxdB-2azkA:
23.3		 4rxdB-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.42A 4rxdC-2azkA:
23.3		 4rxdC-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.35A 4rxdC-2azkA:
23.3		 4rxdC-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.79A 4rxdC-2azkA:
23.3		 4rxdC-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
 None
 0.94A 4rxdC-2azkA:
23.3		 4rxdC-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 10 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.74A 4rxdC-2azkA:
23.3		 4rxdC-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 8 SER A  77
LEU A  78
ASP A  81
ARG A  90
 None
 0.94A 4umjA-2azkA:
27.6		 4umjA-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 8 SER A  77
LEU A  78
ASP A  85
ARG A  90
 None
 0.77A 4umjA-2azkA:
27.6		 4umjA-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 SER A  77
LEU A  78
ASP A  81
ARG A  90
THR A 161
 None
 1.03A 4umjB-2azkA:
27.7		 4umjB-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 SER A  77
LEU A  78
ASP A  85
ARG A  90
THR A 161
 None
 0.79A 4umjB-2azkA:
27.7		 4umjB-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WMZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 TYR A 196
ILE A 194
GLY A 189
THR A 169
LEU A  48
 None
 1.49A 4wmzA-2azkA:
1.4		 4wmzA-2azkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 251
PHE A  51
LEU A 264
LEU A 192
TYR A 244
 None
 1.28A 4xumA-2azkA:
1.9		 4xumA-2azkA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 HIS A  74
GLY A  41
GLU A  71
ARG A  43
 None
 1.31A 4zbqA-2azkA:
3.8		 4zbqA-2azkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 ARG A  45
GLY A 162
SER A 163
LEU A 164
 None
 1.22A 5bphA-2azkA:
undetectable		 5bphA-2azkA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.40A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A  78
ASP A  81
ARG A  90
THR A 139
THR A 161
GLN A 197
 None
 1.01A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 1.02A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A  78
ASP A  85
ARG A  90
THR A 139
THR A 161
GLN A 197
 None
 0.83A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
 None
 0.86A 5cg5A-2azkA:
22.5		 5cg5A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
 None
 1.39A 5cg6A-2azkA:
23.0		 5cg6A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 12 LEU A  78
ASP A  81
ARG A  90
THR A 139
THR A 161
GLN A 197
 None
 1.01A 5cg6A-2azkA:
23.0		 5cg6A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		7 / 12 LEU A  78
ASP A  85
ARG A  90
THR A 139
THR A 161
GLN A 197
ASP A 200
 None
 0.90A 5cg6A-2azkA:
23.0		 5cg6A-2azkA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A  85
ARG A  90
LYS A 160
GLN A 197
ASP A 200
 None
 1.36A 5eroA-2azkA:
22.0		 5eroA-2azkA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 9 LEU A  78
ASP A  85
ARG A  90
GLN A 197
ASP A 200
 None
 0.83A 5eroA-2azkA:
22.0		 5eroA-2azkA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  82
ASP A  85
ARG A  90
GLN A 197
ASP A 200
ASP A 201
 None
 0.94A 5eroC-2azkA:
22.2		 5eroC-2azkA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		6 / 10 ASP A  82
ASP A  85
ARG A  90
LYS A 160
GLN A 197
ASP A 200
 None
 1.38A 5eroC-2azkA:
22.2		 5eroC-2azkA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 8 TYR A 196
ILE A 194
GLY A 189
THR A 169
LEU A  48
 None
 1.48A 5esfA-2azkA:
undetectable		 5esfA-2azkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 135
ILE A 120
TYR A 179
ALA A 173
LEU A 171
 None
 1.13A 5ienB-2azkA:
undetectable		 5ienB-2azkA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		5 / 12 TYR A 240
TYR A 232
LEU A 220
ILE A 157
ILE A 194
 None
 1.20A 5ifuA-2azkA:
undetectable		 5ifuA-2azkA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 PHE A  44
GLY A  46
THR A  47
ASN A  49
 None
 0.64A 5x24A-2azkA:
0.0		 5x24A-2azkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 7 ASP A  85
ARG A  90
LYS A 160
GLN A 197
 None
 1.13A 6g31A-2azkA:
21.3		 6g31A-2azkA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Sulfolobus
solfataricus) 		4 / 6 LEU A  78
ASP A  81
ARG A  90
GLN A 197
 None
 1.18A 6g31J-2azkA:
21.6		 6g31J-2azkA:
14.10