SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2azq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 GLU A 105
TYR A 109
PHE A 224
 None
 0.79A 1eqbB-2azqA:
undetectable		 1eqbB-2azqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 GLU A 105
TYR A 109
PHE A 224
 None
 0.79A 1eqbA-2azqA:
undetectable		 1eqbA-2azqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 GLU A 105
TYR A 109
PHE A 224
 None
 0.78A 1eqbD-2azqA:
undetectable		 1eqbD-2azqA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 GLU A 105
TYR A 109
PHE A 224
 None
 0.79A 1eqbC-2azqA:
undetectable		 1eqbC-2azqA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		8 / 11 ILE A 104
GLY A 106
PRO A 107
TYR A 162
TYR A 196
ARG A 217
HIS A 220
HIS A 222
 None
None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-4.2A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.48A 1s9aA-2azqA:
27.3		 1s9aA-2azqA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 LEU A  72
ILE A 104
GLY A 106
PRO A 107
TYR A 162
 None
None
None
None
FE  A 400 (-4.1A)
 1.37A 1s9aA-2azqA:
27.3		 1s9aA-2azqA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		8 / 11 LEU A  72
ILE A 104
GLY A 106
PRO A 107
TYR A 162
TYR A 196
HIS A 220
HIS A 222
 None
None
None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.53A 1s9aA-2azqA:
27.3		 1s9aA-2azqA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		10 / 12 LEU A  72
ILE A 104
GLY A 106
PRO A 107
TYR A 162
TYR A 196
ARG A 217
HIS A 220
HIS A 222
GLN A 236
 None
None
None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-4.2A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
None
 0.50A 1s9aB-2azqA:
27.5		 1s9aB-2azqA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		7 / 11 GLY A 106
PRO A 107
TYR A 162
TYR A 196
ARG A 217
HIS A 220
HIS A 222
 None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-4.2A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.47A 1tmxA-2azqA:
27.3		 1tmxA-2azqA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 11 LEU A  72
GLY A 106
ARG A 217
HIS A 220
HIS A 222
 None
None
FE  A 400 (-4.2A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.94A 1tmxA-2azqA:
27.3		 1tmxA-2azqA:
29.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		7 / 12 GLY A 106
PRO A 107
TYR A 162
TYR A 196
ARG A 217
HIS A 220
HIS A 222
 None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-4.2A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.35A 1tmxB-2azqA:
26.7		 1tmxB-2azqA:
29.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		9 / 9 THR A  40
LEU A  43
GLU A  53
HIS A  56
ALA A  57
TYR A  60
LEU A  61
GLU A 206
LEU A 210
 PCF  A 954 ( 4.1A)
PCF  A 954 ( 4.9A)
PCF  A 954 (-4.5A)
PCF  A 954 ( 4.5A)
PCF  A 954 (-3.5A)
PCF  A 954 (-4.1A)
None
PCF  A 954 ( 4.6A)
PCF  A 954 (-4.8A)
 0.00A 2azqA-2azqA:
45.6		 2azqA-2azqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A  98
GLY A  97
PHE A 287
ASP A 286
PHE A 139
 None
 1.09A 2dpmA-2azqA:
undetectable		 2dpmA-2azqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		6 / 12 PHE A 224
ALA A 250
PRO A 107
GLY A  71
GLY A  76
TYR A 109
 None
 1.26A 2igtA-2azqA:
undetectable		 2igtA-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 224
ALA A 250
PRO A 107
GLY A  76
TYR A 109
 None
 1.15A 2igtB-2azqA:
undetectable		 2igtB-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 224
PRO A 107
GLY A  71
GLY A  76
TYR A 109
 None
 1.16A 2igtB-2azqA:
undetectable		 2igtB-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 PHE A 224
ALA A 250
PRO A 107
GLY A  76
TYR A 109
 None
 1.12A 2igtC-2azqA:
undetectable		 2igtC-2azqA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 GLY A  98
GLY A  97
ASP A  88
LEU A 233
 None
 0.56A 2oa1B-2azqA:
undetectable		 2oa1B-2azqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 HIS A 155
MET A 132
MET A 122
 None
 1.42A 2vj1A-2azqA:
0.2		 2vj1A-2azqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 286
PHE A 287
LEU A 289
 None
 0.62A 2zi9A-2azqA:
undetectable		 2zi9A-2azqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 ILE A 179
ILE A 178
ALA A 116
MET A 122
ALA A 113
 None
 1.05A 3gwsX-2azqA:
undetectable		 3gwsX-2azqA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		8 / 12 ILE A 104
GLY A 106
PRO A 107
TYR A 162
TYR A 196
ARG A 217
HIS A 220
HIS A 222
 None
None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-4.2A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.52A 3hgiA-2azqA:
27.9		 3hgiA-2azqA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		8 / 12 LEU A  72
ILE A 104
GLY A 106
PRO A 107
TYR A 162
TYR A 196
HIS A 220
HIS A 222
 None
None
None
None
FE  A 400 (-4.1A)
FE  A 400 (-4.4A)
FE  A 400 (-3.6A)
FE  A 400 (-3.2A)
 0.60A 3hgiA-2azqA:
27.9		 3hgiA-2azqA:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 10 ALA A 252
ASP A 248
PHE A 249
LEU A 108
THR A 253
 None
 1.42A 4eilB-2azqA:
undetectable		 4eilB-2azqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 127
ARG A 176
THR A 158
 None
 0.87A 4i13A-2azqA:
undetectable		 4i13A-2azqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		4 / 7 ASN A 173
VAL A 120
ARG A 189
ARG A 121
 None
 1.14A 4ijiH-2azqA:
undetectable		 4ijiH-2azqA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		4 / 6 ILE A 191
ASP A 123
ARG A 121
VAL A 275
 None
 1.09A 4oltB-2azqA:
undetectable		 4oltB-2azqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 127
ARG A 176
THR A 158
 None
 0.89A 4p3rA-2azqA:
undetectable		 4p3rA-2azqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 THR A 234
ASP A  84
ILE A 225
SER A 226
HIS A 232
 None
 1.15A 4pooB-2azqA:
undetectable		 4pooB-2azqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 ALA A  74
LEU A  72
LEU A 208
PHE A  82
GLY A  78
 None
 1.35A 5jglA-2azqA:
undetectable		 5jglA-2azqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 LEU A  61
ASN A  62
LEU A  64
GLY A  65
GLY A  66
 None
 0.50A 5uc1B-2azqA:
undetectable		 5uc1B-2azqA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		3 / 3 ASP A 127
ASN A 157
ASP A 166
 None
 0.89A 5vopB-2azqA:
undetectable		 5vopB-2azqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 2azq CATECHOL
1,2-DIOXYGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 195
VAL A 192
GLY A  76
HIS A 222
ASN A 238
 None
None
None
FE  A 400 (-3.2A)
None
 1.04A 6gngA-2azqA:
undetectable		 6gngA-2azqA:
17.98