SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A  40
GLY A 124
LEU A 139
HIS A 136
ILE A 130
 None
 1.27A 1kyvC-2b0aA:
undetectable
1kyvD-2b0aA:
undetectable		 1kyvC-2b0aA:
24.10
1kyvD-2b0aA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A  40
GLY A 124
LEU A 139
HIS A 136
ILE A 130
 None
 1.26A 1kyvD-2b0aA:
undetectable
1kyvE-2b0aA:
undetectable		 1kyvD-2b0aA:
24.10
1kyvE-2b0aA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.89A 1v7zA-2b0aA:
undetectable		 1v7zA-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.89A 1v7zB-2b0aA:
undetectable		 1v7zB-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.89A 1v7zC-2b0aA:
undetectable		 1v7zC-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.88A 1v7zD-2b0aA:
undetectable		 1v7zD-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.89A 1v7zE-2b0aA:
undetectable		 1v7zE-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.88A 1v7zF-2b0aA:
undetectable		 1v7zF-2b0aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A  98
GLU A 152
ILE A  10
CYH A  42
GLN A   7
 None
 1.49A 2dr2A-2b0aA:
undetectable		 2dr2A-2b0aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.92A 3a6jA-2b0aA:
undetectable		 3a6jA-2b0aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.93A 3a6jB-2b0aA:
undetectable		 3a6jB-2b0aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.91A 3a6jC-2b0aA:
undetectable		 3a6jC-2b0aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.92A 3a6jE-2b0aA:
undetectable		 3a6jE-2b0aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 8 GLU A 148
HIS A  44
ASP A  46
HIS A 136
 None
 0.91A 3a6jF-2b0aA:
undetectable		 3a6jF-2b0aA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 185
LEU A   3
LEU A  88
LEU A 154
 None
 1.07A 3q1eA-2b0aA:
0.0
3q1eC-2b0aA:
0.0		 3q1eA-2b0aA:
18.18
3q1eC-2b0aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 130
ALA A 127
SER A  72
ILE A  71
LEU A  87
 None
 1.21A 4qi9C-2b0aA:
undetectable		 4qi9C-2b0aA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 121
LEU A 140
ILE A  45
 None
 0.69A 5kc0A-2b0aA:
undetectable		 5kc0A-2b0aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		3 / 3 LYS A 121
LEU A 140
ILE A  45
 None
 0.62A 5kc4A-2b0aA:
undetectable		 5kc4A-2b0aA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  46
HIS A  50
HIS A 136
HIS A  44
 None
 0.70A 5ncdB-2b0aA:
undetectable
5ncdC-2b0aA:
undetectable		 5ncdB-2b0aA:
19.69
5ncdC-2b0aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A  36
ASN A  11
CYH A  42
 None
 0.84A 6bp4A-2b0aA:
undetectable		 6bp4A-2b0aA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2b0a HYPOTHETICAL PROTEIN
MJ0783
(Methanocaldococc
us
jannaschii) 		3 / 3 LEU A 185
ASN A 151
LEU A  88
 None
 0.60A 6exiD-2b0aA:
undetectable		 6exiD-2b0aA:
20.32