SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b0c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		3 / 3 ARG A 104
ILE A  18
THR A 116
 None
 0.70A 3ia4D-2b0cA:
undetectable		 3ia4D-2b0cA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		6 / 12 ILE A  11
VAL A 111
LEU A 113
ALA A 160
LEU A 158
LEU A   9
 None
 1.41A 4m11B-2b0cA:
undetectable		 4m11B-2b0cA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		5 / 12 ASP A  13
SER A 114
ASP A 173
GLU A  55
GLU A 150
 G1P  A 496 (-2.2A)
G1P  A 496 (-2.6A)
G1P  A 496 (-2.4A)
None
None
 1.44A 5iqbA-2b0cA:
undetectable		 5iqbA-2b0cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		5 / 11 ASP A  13
SER A 114
ASP A 173
GLU A  55
GLU A 150
 G1P  A 496 (-2.2A)
G1P  A 496 (-2.6A)
G1P  A 496 (-2.4A)
None
None
 1.44A 5iqbB-2b0cA:
0.0		 5iqbB-2b0cA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 2b0c PUTATIVE PHOSPHATASE
(Escherichia
coli) 		5 / 12 ASP A  13
SER A 114
ASP A 173
GLU A  55
GLU A 150
 G1P  A 496 (-2.2A)
G1P  A 496 (-2.6A)
G1P  A 496 (-2.4A)
None
None
 1.44A 5iqbD-2b0cA:
undetectable		 5iqbD-2b0cA:
20.19