SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b0o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2b0o UPLC1
(Homo
sapiens) 		4 / 8 CYH E 464
ASP E 443
CYH E 441
GLY E 445
 ZN  E 698 (-2.3A)
None
ZN  E 698 (-2.3A)
None
 1.00A 1ekjA-2b0oE:
undetectable
1ekjB-2b0oE:
undetectable		 1ekjA-2b0oE:
23.57
1ekjB-2b0oE:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 2b0o UPLC1
(Homo
sapiens) 		5 / 12 ASN E 455
HIS E 468
VAL E 432
LEU E 459
THR E 460
 None
 1.09A 1oq5A-2b0oE:
undetectable		 1oq5A-2b0oE:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2b0o UPLC1
(Homo
sapiens) 		4 / 8 ASP E 443
LEU E 456
HIS E 468
HIS E 538
 None
 0.78A 2q0iA-2b0oE:
undetectable		 2q0iA-2b0oE:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 9 ASN E 611
PHE E 502
TYR E 535
LEU E 564
HIS E 538
 None
 1.06A 3fbwA-2b0oE:
undetectable		 3fbwA-2b0oE:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 12 ALA E 646
LEU E 638
THR E 657
ILE E 661
LEU E 674
 None
 1.18A 3nrrA-2b0oE:
undetectable		 3nrrA-2b0oE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 12 ALA E 630
HIS E 591
LEU E 626
ILE E 609
LEU E 642
 None
 1.20A 3nrrB-2b0oE:
undetectable		 3nrrB-2b0oE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 12 ALA E 646
LEU E 638
THR E 657
ILE E 661
LEU E 674
 None
 1.19A 3nrrB-2b0oE:
undetectable		 3nrrB-2b0oE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 10 CYH E 464
ASP E 443
CYH E 441
GLY E 445
ALA E 446
 ZN  E 698 (-2.3A)
None
ZN  E 698 (-2.3A)
None
ZN  E 698 ( 4.5A)
 1.19A 3ucjA-2b0oE:
undetectable		 3ucjA-2b0oE:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 10 CYH E 464
ASP E 443
CYH E 441
GLY E 445
ALA E 446
 ZN  E 698 (-2.3A)
None
ZN  E 698 (-2.3A)
None
ZN  E 698 ( 4.5A)
 1.15A 3ucjB-2b0oE:
undetectable		 3ucjB-2b0oE:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2b0o UPLC1
(Homo
sapiens) 		4 / 6 ASN E 499
CYH E 441
ASP E 443
ILE E 531
 None
ZN  E 698 (-2.3A)
None
None
 1.50A 3w9tB-2b0oE:
undetectable		 3w9tB-2b0oE:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2b0o UPLC1
(Homo
sapiens) 		5 / 12 LEU E 641
ILE E 609
ILE E 608
ALA E 617
VAL E 589
 None
 1.16A 4nkvC-2b0oE:
undetectable		 4nkvC-2b0oE:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2b0o UPLC1
(Homo
sapiens) 		5 / 11 LEU E 659
LEU E 638
LEU E 673
HIS E 627
LEU E 626
 None
 1.32A 4zn7B-2b0oE:
undetectable		 4zn7B-2b0oE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2b0o UPLC1
(Homo
sapiens) 		3 / 3 ASP E 572
VAL E 589
LEU E 551
 None
 0.66A 5e5jB-2b0oE:
undetectable		 5e5jB-2b0oE:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 2b0o UPLC1
(Homo
sapiens) 		5 / 12 LEU E 564
LEU E 561
GLY E 457
GLY E 498
GLY E 437
 None
 1.10A 6ce2B-2b0oE:
undetectable		 6ce2B-2b0oE:
17.65