SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AZM_A_AZMA262_1
(CARBONIC ANHYDRASE I)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 233
HIS A 251
LEU A 370
THR A 369
 None
 1.00A 1azmA-2b0tA:
undetectable		 1azmA-2b0tA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 LEU A  14
SER A 713
ASN A 715
 None
 0.77A 1bx4A-2b0tA:
undetectable		 1bx4A-2b0tA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 PHE A 233
HIS A 251
LEU A 370
THR A 369
 None
 0.98A 1bzmA-2b0tA:
undetectable		 1bzmA-2b0tA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 562
ILE A 528
THR A 402
MET A 400
 None
 1.10A 1kglA-2b0tA:
undetectable		 1kglA-2b0tA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 734
PHE A 729
VAL A  23
 None
 0.69A 1kijB-2b0tA:
undetectable		 1kijB-2b0tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.85A 1p7lD-2b0tA:
undetectable		 1p7lD-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.82A 1p7lC-2b0tA:
undetectable		 1p7lC-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 433
ILE A 442
ILE A 186
LEU A 214
GLN A 456
 None
 1.04A 1qhyA-2b0tA:
2.5		 1qhyA-2b0tA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.86A 1rg9B-2b0tA:
undetectable		 1rg9B-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.85A 1rg9A-2b0tA:
undetectable		 1rg9A-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.85A 1rg9D-2b0tA:
undetectable		 1rg9D-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.83A 1rg9C-2b0tA:
undetectable		 1rg9C-2b0tA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLN A 590
THR A 706
ASP A 707
LEU A  14
LEU A 719
 None
 1.04A 1rjdA-2b0tA:
undetectable		 1rjdA-2b0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLN A 590
THR A 706
ASP A 707
LEU A  14
LEU A 719
 None
 1.08A 1rjdB-2b0tA:
undetectable		 1rjdB-2b0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLN A 590
THR A 706
ASP A 707
LEU A  14
LEU A 719
 None
 1.05A 1rjdC-2b0tA:
undetectable		 1rjdC-2b0tA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 295
LEU A 337
LEU A 234
VAL A 238
ILE A 298
 None
 1.08A 1s9pA-2b0tA:
undetectable		 1s9pA-2b0tA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 GLY A  44
SER A  41
VAL A 127
LEU A  98
 None
 1.29A 1yajB-2b0tA:
undetectable		 1yajB-2b0tA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 THR A 169
THR A 369
SER A 249
VAL A 343
 None
 1.08A 2fb2B-2b0tA:
undetectable		 2fb2B-2b0tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 7 LEU A 234
PHE A 273
ILE A 372
ASN A 336
PHE A 248
 None
 1.48A 2opxA-2b0tA:
undetectable		 2opxA-2b0tA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A  40
THR A   9
ASN A  77
VAL A 132
ILE A   4
 None
 1.07A 2vn0A-2b0tA:
undetectable		 2vn0A-2b0tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 ILE A 528
ILE A 525
ILE A 353
PHE A 395
THR A 534
 None
 1.21A 2w9sC-2b0tA:
2.2		 2w9sC-2b0tA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z2P_B_DOLB2003_1
(VIRGINIAMYCIN B
LYASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 ASN A 615
GLU A 613
GLY A 572
SER A 609
GLU A 608
 None
 1.21A 2z2pA-2b0tA:
0.0
2z2pB-2b0tA:
0.0		 2z2pA-2b0tA:
15.50
2z2pB-2b0tA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 VAL A 127
ASP A  10
TYR A 124
ILE A 105
 None
 0.92A 3avpA-2b0tA:
3.2		 3avpA-2b0tA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 GLY A 294
GLY A 266
GLY A 291
 None
 0.38A 3bogC-2b0tA:
undetectable		 3bogC-2b0tA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ASN A  77
VAL A  24
ALA A  28
ALA A 626
THR A  17
 None
 1.08A 3czhA-2b0tA:
undetectable		 3czhA-2b0tA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ASN A  77
VAL A  24
ALA A  28
ALA A 626
THR A  17
 None
 1.06A 3dl9B-2b0tA:
undetectable		 3dl9B-2b0tA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 TYR A 416
ALA A 172
ASP A 346
ASP A 544
VAL A 541
 None
None
MG  A 800 (-3.3A)
MG  A 800 (-3.0A)
None
 1.05A 3dmfA-2b0tA:
undetectable		 3dmfA-2b0tA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 ARG A  38
ILE A  40
VAL A 135
THR A  73
 None
 1.02A 3eigA-2b0tA:
2.1		 3eigA-2b0tA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 ILE A 528
PHE A 395
ILE A 525
THR A 399
 None
 0.88A 3ia4A-2b0tA:
undetectable		 3ia4A-2b0tA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 266
ASN A 290
GLY A 291
ILE A 372
PHE A 233
 None
 0.99A 3ihtA-2b0tA:
2.5		 3ihtA-2b0tA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 VAL A 381
VAL A 403
SER A 536
 None
 0.70A 3n8xB-2b0tA:
undetectable		 3n8xB-2b0tA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 ASP A 548
SER A 558
ASP A 346
GLU A 575
 MG  A 800 (-2.8A)
None
MG  A 800 (-3.3A)
None
 1.09A 3sg9B-2b0tA:
undetectable		 3sg9B-2b0tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 LEU A 567
GLY A 570
PHE A 574
ASN A 617
 None
 1.10A 3uq6B-2b0tA:
undetectable		 3uq6B-2b0tA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 337
PHE A 273
LYS A 317
GLY A 318
 None
 0.92A 4hajA-2b0tA:
undetectable		 4hajA-2b0tA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 LEU A 337
PHE A 273
LYS A 317
GLY A 318
 None
 1.06A 4hc3A-2b0tA:
undetectable		 4hc3A-2b0tA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 TYR A 378
HIS A 490
ARG A 488
 None
 1.07A 4htfA-2b0tA:
undetectable		 4htfA-2b0tA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 GLY A  44
TYR A 712
SER A  41
GLU A  11
 None
 0.92A 4hyfA-2b0tA:
undetectable		 4hyfA-2b0tA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A  44
TYR A 712
SER A  41
GLU A  11
 None
 0.89A 4hyfC-2b0tA:
undetectable		 4hyfC-2b0tA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLU A 415
ASP A 178
ASP A 261
ILE A 264
 None
 0.83A 4kttB-2b0tA:
undetectable		 4kttB-2b0tA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 549
ILE A 353
MET A 352
ASN A 170
GLY A 380
 None
 0.92A 4lmnA-2b0tA:
undetectable		 4lmnA-2b0tA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 11 HIS A 490
GLU A 415
VAL A 219
LEU A 497
LEU A 408
 None
 1.17A 4lu3A-2b0tA:
undetectable		 4lu3A-2b0tA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 381
ALA A 379
TYR A 382
PHE A 550
THR A 521
 None
 1.27A 4mm4B-2b0tA:
undetectable		 4mm4B-2b0tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ASN A 405
ILE A 535
PRO A 479
ASP A 511
GLN A 513
 None
 1.31A 4uroA-2b0tA:
undetectable		 4uroA-2b0tA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A 234
ILE A 264
HIS A 267
VAL A 268
 None
 1.19A 4xyzA-2b0tA:
undetectable		 4xyzA-2b0tA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  44
TYR A 103
ALA A  63
GLU A  66
ALA A  48
 None
 1.31A 4ymgA-2b0tA:
undetectable		 4ymgA-2b0tA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 139
PRO A 461
ALA A 460
LEU A 573
ALA A  71
 None
 1.21A 5bw4B-2b0tA:
undetectable		 5bw4B-2b0tA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLU A 602
GLY A 601
LEU A 562
SER A 563
VAL A 149
 None
 1.13A 5dpdA-2b0tA:
undetectable		 5dpdA-2b0tA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 552
GLY A 556
SER A 524
ILE A 528
MET A 400
 None
 1.27A 5igwA-2b0tA:
undetectable		 5igwA-2b0tA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 GLY A 709
GLN A 590
LYS A 718
 None
 0.85A 5imsB-2b0tA:
undetectable		 5imsB-2b0tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 PHE A 574
ILE A  79
ILE A   4
PHE A 610
ALA A 626
 None
 1.21A 5nukA-2b0tA:
undetectable		 5nukA-2b0tA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 7 ARG A 137
LEU A 573
THR A   7
ILE A  40
LEU A  67
 None
 1.02A 5te8C-2b0tA:
0.6		 5te8C-2b0tA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 GLY A 572
ARG A 144
VAL A 565
ASP A 142
 None
 1.05A 5vlmA-2b0tA:
undetectable		 5vlmA-2b0tA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A  65
GLU A 138
LEU A  70
ILE A  78
VAL A 132
 None
 1.30A 5vlmB-2b0tA:
undetectable		 5vlmB-2b0tA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 694
ASP A 651
GLY A 654
PHE A 657
MET A 723
 None
 1.02A 5x5qB-2b0tA:
undetectable		 5x5qB-2b0tA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 ASN A 177
ASP A 450
ASP A 428
GLY A 429
 None
 1.11A 5x7pA-2b0tA:
undetectable		 5x7pA-2b0tA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A 481
ALA A 520
SER A 524
GLY A 539
LEU A 542
 None
 1.03A 6b0iB-2b0tA:
undetectable		 6b0iB-2b0tA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 SER A 655
ASN A 730
PHE A 729
VAL A  35
 None
 0.81A 6dwnB-2b0tA:
undetectable		 6dwnB-2b0tA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 PHE A 729
ARG A 724
ALA A  26
 None
 0.93A 6ecfB-2b0tA:
undetectable		 6ecfB-2b0tA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2b0t NADP ISOCITRATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 VAL A 457
GLU A 218
ILE A 462
 None
 0.65A 6f7lB-2b0tA:
undetectable		 6f7lB-2b0tA:
20.48