SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R5L_A_VIVA301_1 (PROTEIN (ALPHA-TOCOPHEROL TRANSFER PROTEIN))	2b18	GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY (Bacillus subtilis)	4 / 4	SER A 37 SER A 129 LEU A 126 PHE A 40	None	1.43A	1r5lA-2b18A: 0.0	1r5lA-2b18A: 21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FWD_A_BO2A801_1 (TTC1975 PEPTIDASE)	2b18	GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY (Bacillus subtilis)	5 / 9	VAL A 150 VAL A 149 VAL A 114 ILE A 116 GLY A 118	None	1.22A	4fwdA-2b18A: undetectable	4fwdA-2b18A: 12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD9_A_ADNA501_2 (NUPC FAMILY PROTEIN)	2b18	GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY (Bacillus subtilis)	3 / 3	THR A 111 ASN A 81 PHE A 80	None	0.59A	4pd9A-2b18A: undetectable	4pd9A-2b18A: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ECE_C_DVAC3010_0 (VLM2 DODECADEPSIPEPTIDE)	2b18	GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY (Bacillus subtilis)	3 / 3	ALA A 108 PHE A 98 GLN A 55	None	0.74A	6eceA-2b18A: undetectable	6eceA-2b18A: 19.94

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1R5L_A_VIVA301_1","PROTEIN (ALPHA-TOCOPHEROL TRANSFER PROTEIN)","2b18","GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY","Bacillus subtilis",4,"SER A  37;SER A 129;LEU A 126;PHE A  40","None","1.43A","1r5lA-2b18A:0.0","1r5lA-2b18A:21.11"],["4FWD_A_BO2A801_1","TTC1975 PEPTIDASE","2b18","GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY","Bacillus subtilis",5,"VAL A 150;VAL A 149;VAL A 114;ILE A 116;GLY A 118","None","1.22A","4fwdA-2b18A:undetectable","4fwdA-2b18A:12.79"],["4PD9_A_ADNA501_2","NUPC FAMILY PROTEIN","2b18","GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY","Bacillus subtilis",3,"THR A 111;ASN A  81;PHE A  80","None","0.59A","4pd9A-2b18A:undetectable","4pd9A-2b18A:17.32"],["6ECE_C_DVAC3010_0","VLM2;DODECADEPSIPEPTIDE","2b18","GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY","Bacillus subtilis",3,"ALA A 108;PHE A  98;GLN A  55","None","0.74A","6eceA-2b18A:undetectable","6eceA-2b18A:19.94"]]