SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2b1h FAB 2219, HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 TYR H  52
LEU H  95
GLY H  96
GLY H 100
 None
 0.52A 1rukH-2b1hH:
18.0
1rukL-2b1hH:
17.7		 1rukH-2b1hH:
53.95
1rukL-2b1hH:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2b1h FAB 2219, HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 LEU H 198
GLY H 199
ALA H 125
PRO H 126
 None
 0.35A 3huoA-2b1hH:
undetectable		 3huoA-2b1hH:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2b1h FAB 2219, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 PHE H 148
LYS H  13
SER H  14
 None
 1.23A 3tyeB-2b1hH:
undetectable		 3tyeB-2b1hH:
20.82