SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b1p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 6 ILE A  70
VAL A  78
ILE A 123
ILE A 185
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
None
None
 0.86A 1uwhB-2b1pA:
4.5		 1uwhB-2b1pA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		6 / 9 VAL A  78
LYS A  93
LEU A 126
LEU A 144
LEU A 148
MET A 149
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.8A)
None
AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.49A 1xkkA-2b1pA:
18.4		 1xkkA-2b1pA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		3 / 3 GLY A 209
GLU A 111
ASP A 189
 None
 0.42A 2b25B-2b1pA:
undetectable		 2b25B-2b1pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		3 / 3 LEU A 144
LEU A 148
MET A 149
 AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.42A 2itzA-2b1pA:
19.5		 2itzA-2b1pA:
24.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 12 VAL A  78
ALA A  91
ILE A 124
HIS A 187
ASP A 207
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
None
None
None
 0.81A 3gcsA-2b1pA:
34.5		 3gcsA-2b1pA:
48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 7 LEU A 144
LEU A 148
MET A 149
ILE A 205
 AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
None
 0.76A 3gp0A-2b1pA:
35.7		 3gp0A-2b1pA:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 7 LYS A  93
LEU A 144
LEU A 148
ILE A 205
 AIZ  A 501 (-3.8A)
AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.94A 3gp0A-2b1pA:
35.7		 3gp0A-2b1pA:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 8 ALA A  91
LYS A  93
LEU A 144
LEU A 148
MET A 149
 AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.39A 3lfaA-2b1pA:
34.3		 3lfaA-2b1pA:
48.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 6 ASN A 152
TYR A 229
GLU A 255
ILE A 157
 AIZ  A 501 (-3.6A)
None
None
None
 1.04A 3q5sA-2b1pA:
0.3		 3q5sA-2b1pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 6 GLN A 100
ASP A 141
GLN A 140
GLU A  52
 None
 1.41A 4azvA-2b1pA:
2.6		 4azvA-2b1pA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 5 VAL A  78
ILE A 123
MET A 149
ILE A 205
 AIZ  A 501 ( 4.7A)
None
None
None
 0.50A 4c8bA-2b1pA:
20.1		 4c8bA-2b1pA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 5 VAL A  78
ILE A 205
MET A 149
ILE A 195
 AIZ  A 501 ( 4.7A)
None
None
None
 0.93A 4c8bA-2b1pA:
20.1		 4c8bA-2b1pA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		3 / 3 LYS A 191
PRO A 192
SER A 193
 None
 0.20A 4k50I-2b1pA:
undetectable		 4k50I-2b1pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 6 LEU A 203
ASN A 122
MET A 256
LEU A 170
VAL A 350
 None
 1.33A 4okbA-2b1pA:
undetectable		 4okbA-2b1pA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 6 LEU A 203
ASN A 122
MET A 256
LEU A 170
 None
 1.10A 4okxA-2b1pA:
undetectable		 4okxA-2b1pA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 8 VAL A 350
HIS A 187
ASP A 245
HIS A 181
 None
 0.93A 5a5zA-2b1pA:
undetectable		 5a5zA-2b1pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 4 LEU A 290
TYR A 240
PRO A 232
ILE A 342
 None
None
None
SO4  A 503 (-3.7A)
 1.36A 5esgA-2b1pA:
undetectable		 5esgA-2b1pA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 8 ILE A  70
VAL A  78
ILE A 123
ILE A 185
ILE A 205
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
None
None
None
 1.08A 5hi2A-2b1pA:
19.1		 5hi2A-2b1pA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 7 CYH A 175
ILE A 177
LEU A 354
ALA A 353
 None
 1.00A 5hrqE-2b1pA:
undetectable
5hrqF-2b1pA:
undetectable
5hrqJ-2b1pA:
undetectable		 5hrqE-2b1pA:
4.92
5hrqF-2b1pA:
11.79
5hrqJ-2b1pA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 6 VAL A 197
ALA A 151
GLN A 155
VAL A 156
 None
None
AIZ  A 501 (-2.6A)
None
 0.87A 5i8fA-2b1pA:
undetectable		 5i8fA-2b1pA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 12 TRP A 272
ASP A 343
ARG A 347
GLU A 233
LEU A 236
 None
SO4  A 503 (-4.7A)
None
None
None
 1.46A 5l7iA-2b1pA:
2.1		 5l7iA-2b1pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_B_VISB1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 12 TRP A 272
ASP A 343
ARG A 347
GLU A 233
LEU A 236
 None
SO4  A 503 (-4.7A)
None
None
None
 1.45A 5l7iB-2b1pA:
2.0		 5l7iB-2b1pA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		6 / 9 ILE A  70
GLY A  71
ALA A  91
MET A 149
ASN A 152
LEU A 206
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.0A)
AIZ  A 501 (-3.4A)
None
AIZ  A 501 (-3.6A)
AIZ  A 501 (-4.0A)
 0.91A 5lw1B-2b1pA:
43.9		 5lw1B-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		6 / 9 ILE A  70
VAL A  78
ALA A  91
MET A 146
ASN A 152
LEU A 206
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 (-3.6A)
AIZ  A 501 (-4.0A)
 0.81A 5lw1B-2b1pA:
43.9		 5lw1B-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		6 / 9 ILE A  70
VAL A  78
ALA A  91
MET A 149
ASN A 152
LEU A 206
 AIZ  A 501 ( 4.5A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
None
AIZ  A 501 (-3.6A)
AIZ  A 501 (-4.0A)
 0.57A 5lw1B-2b1pA:
43.9		 5lw1B-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		6 / 10 ALA A  91
MET A 146
LEU A 148
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.85A 5lw1E-2b1pA:
43.5		 5lw1E-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		7 / 10 GLY A  71
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.0A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.91A 5lw1E-2b1pA:
43.5		 5lw1E-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		7 / 10 VAL A  78
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.59A 5lw1E-2b1pA:
43.5		 5lw1E-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		7 / 9 GLY A  71
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.0A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.91A 5lw1H-2b1pA:
43.9		 5lw1H-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		7 / 9 VAL A  78
ALA A  91
LEU A 148
MET A 149
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 ( 4.7A)
None
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.49A 5lw1H-2b1pA:
43.9		 5lw1H-2b1pA:
93.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		7 / 9 VAL A  78
ALA A  91
MET A 146
LEU A 148
ASN A 152
VAL A 196
LEU A 206
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.6A)
None
AIZ  A 501 (-4.0A)
 0.73A 5lw1H-2b1pA:
43.9		 5lw1H-2b1pA:
93.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 12 VAL A  78
ALA A  91
LYS A  93
LEU A 144
MET A 146
 AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 (-4.2A)
AIZ  A 501 (-3.8A)
 0.45A 5yu9C-2b1pA:
18.0		 5yu9C-2b1pA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		3 / 3 ALA A  91
VAL A  60
TYR A  64
 AIZ  A 501 (-3.4A)
None
None
 0.66A 5zmqH-2b1pA:
undetectable		 5zmqH-2b1pA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		5 / 9 VAL A 361
LEU A 335
ALA A 353
VAL A 350
SER A 349
 None
 1.32A 6c2mB-2b1pA:
0.7		 6c2mB-2b1pA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10
(Homo
sapiens) 		4 / 8 VAL A 350
HIS A 179
ASN A 122
GLU A 367
 None
 1.32A 6gneB-2b1pA:
undetectable		 6gneB-2b1pA:
21.19