SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 111
GLY A 113
SER A 114
ARG A 137
ASP A 173
MET A 193
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
None
SAM  A 601 (-3.4A)
SAM  A 601 ( 4.2A)
 0.59A 1i9gA-2b25A:
25.8		 1i9gA-2b25A:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.19A 1i9gA-2b25A:
25.8		 1i9gA-2b25A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 109
GLY A 111
GLU A 135
ASP A 173
 None
SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
 0.60A 1jg4A-2b25A:
12.9		 1jg4A-2b25A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLU A 109
GLY A 111
GLY A 113
ASP A 173
ILE A 174
 None
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.4A)
SAM  A 601 (-4.2A)
 0.66A 1qaoA-2b25A:
12.6		 1qaoA-2b25A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 8 GLY A 113
GLY A 115
GLY A 116
MET A 117
 SAM  A 601 (-3.2A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.5A)
None
 0.59A 1qzzA-2b25A:
14.1		 1qzzA-2b25A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 5 LYS A  44
PHE A  53
LEU A  58
LEU A 157
 None
 1.22A 1skxA-2b25A:
0.0		 1skxA-2b25A:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 113
GLY A 116
ARG A 137
HIS A 140
ILE A 170
 SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
None
SAM  A 601 (-4.0A)
None
 0.99A 2b25A-2b25A:
41.6		 2b25A-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		12 / 12 THR A  84
THR A  87
GLY A 111
GLY A 113
GLY A 116
MET A 117
VAL A 136
ARG A 137
HIS A 140
ASP A 173
ILE A 174
MET A 193
 SAM  A 601 (-3.8A)
SAM  A 601 (-3.7A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
None
SAM  A 601 (-4.0A)
None
SAM  A 601 (-4.0A)
SAM  A 601 (-3.4A)
SAM  A 601 (-4.2A)
SAM  A 601 ( 4.2A)
 0.01A 2b25A-2b25A:
41.6		 2b25A-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 113
SER A 114
GLY A 116
ARG A 137
HIS A 140
ILE A 170
 SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-3.5A)
None
SAM  A 601 (-4.0A)
None
 1.22A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 THR A  84
SER A 114
GLY A 115
ARG A 137
MET A 193
 SAM  A 601 (-3.8A)
SAM  A 601 (-4.8A)
SAM  A 601 (-4.1A)
None
SAM  A 601 ( 4.2A)
 1.16A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		12 / 12 THR A  84
THR A  87
GLY A 113
SER A 114
GLY A 116
MET A 117
VAL A 136
ARG A 137
HIS A 140
ASP A 173
ILE A 174
MET A 193
 SAM  A 601 (-3.8A)
SAM  A 601 (-3.7A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-3.5A)
None
SAM  A 601 (-4.0A)
None
SAM  A 601 (-4.0A)
SAM  A 601 (-3.4A)
SAM  A 601 (-4.2A)
SAM  A 601 ( 4.2A)
 0.34A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		3 / 3 GLY A 111
GLU A 135
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.5A)
 0.12A 2b25B-2b25A:
37.0		 2b25B-2b25A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 10 PHE A 186
LEU A  96
LEU A 121
ALA A 124
VAL A 131
 None
 0.75A 2bxeA-2b25A:
undetectable		 2bxeA-2b25A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.73A 2pxcA-2b25A:
8.6		 2pxcA-2b25A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 THR A  84
GLY A 111
GLY A 113
ASP A 173
ASP A 192
 SAM  A 601 (-3.8A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.46A 2yvlD-2b25A:
24.6		 2yvlD-2b25A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 11 GLU A 109
GLY A 111
GLY A 113
GLU A 135
HIS A 140
ASP A 173
 None
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.4A)
 0.98A 3dxyA-2b25A:
12.6		 3dxyA-2b25A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 11 GLU A 109
GLY A 111
GLY A 113
GLU A 135
VAL A 136
HIS A 140
 None
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-4.0A)
 1.00A 3dxyA-2b25A:
12.6		 3dxyA-2b25A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 119
SER A 122
ARG A 152
LEU A  73
 None
 0.88A 3f33A-2b25A:
undetectable		 3f33A-2b25A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.70A 3gczA-2b25A:
9.1		 3gczA-2b25A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 111
GLY A 113
GLY A 115
ASP A 173
ILE A 174
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.4A)
SAM  A 601 (-4.2A)
SAM  A 601 (-3.5A)
 0.91A 3ihtA-2b25A:
10.9		 3ihtA-2b25A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 4 GLY A 111
GLU A 135
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.36A 3mb5A-2b25A:
23.8		 3mb5A-2b25A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 3p97A-2b25A:
8.2		 3p97A-2b25A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 3p97C-2b25A:
8.3		 3p97C-2b25A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 119
SER A 122
ARG A 152
LEU A  73
 None
 0.94A 3ravA-2b25A:
undetectable		 3ravA-2b25A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 119
SER A 122
ARG A 152
LEU A  73
 None
 0.91A 3rd0A-2b25A:
undetectable		 3rd0A-2b25A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 6 GLY A 113
GLU A 135
ASP A 173
ASP A 192
 SAM  A 601 (-3.2A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.58A 3vywC-2b25A:
11.3		 3vywC-2b25A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 111
GLY A 115
GLY A 116
ASP A 173
ASP A 192
MET A 193
 SAM  A 601 (-2.9A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
SAM  A 601 ( 4.2A)
 0.82A 4b17A-2b25A:
11.9		 4b17A-2b25A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 9 LEU A  73
LEU A 119
GLY A 116
VAL A 131
VAL A 167
 None
None
SAM  A 601 (-3.5A)
None
None
 1.36A 4c9kB-2b25A:
undetectable		 4c9kB-2b25A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.64A 4ctjA-2b25A:
8.2		 4ctjA-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.65A 4ctkA-2b25A:
8.4		 4ctkA-2b25A:
24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
HIS A 140
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.47A 5c0oE-2b25A:
25.7		 5c0oE-2b25A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 12 GLY A 113
GLY A 115
GLY A 116
GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-3.2A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.98A 5c0oF-2b25A:
26.9		 5c0oF-2b25A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 12 THR A  87
GLY A 113
GLY A 115
GLY A 116
HIS A 140
ASP A 192
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 1.00A 5c0oF-2b25A:
26.9		 5c0oF-2b25A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 THR A  87
GLY A 111
GLY A 113
GLY A 116
ARG A 137
 SAM  A 601 (-3.7A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
None
 0.76A 5c0oG-2b25A:
26.8		 5c0oG-2b25A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		3 / 3 GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.32A 5c0oG-2b25A:
26.8		 5c0oG-2b25A:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 5 THR A  87
GLY A 116
GLU A 135
HIS A 140
ASP A 192
 SAM  A 601 (-3.7A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.9A)
SAM  A 601 (-4.0A)
SAM  A 601 (-3.5A)
 0.76A 5c0oH-2b25A:
25.7		 5c0oH-2b25A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.65A 5e9qA-2b25A:
8.0		 5e9qA-2b25A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.67A 5e9qC-2b25A:
8.0		 5e9qC-2b25A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 5ec8C-2b25A:
undetectable		 5ec8C-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.67A 5ehgA-2b25A:
8.3		 5ehgA-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.64A 5ehiA-2b25A:
7.4		 5ehiA-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 5ehiC-2b25A:
undetectable		 5ehiC-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.65A 5eifA-2b25A:
7.4		 5eifA-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 5eifC-2b25A:
7.8		 5eifC-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 5eiwA-2b25A:
8.1		 5eiwA-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.73A 5eiwC-2b25A:
8.1		 5eiwC-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.67A 5ekxA-2b25A:
8.3		 5ekxA-2b25A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		6 / 7 GLY A 111
GLY A 113
SER A 114
GLU A 135
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.76A 5ergB-2b25A:
22.0		 5ergB-2b25A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 173
ASP A 192
GLY A 113
SER A 114
GLU A 135
 SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-2.9A)
 1.03A 5hfjD-2b25A:
3.4		 5hfjD-2b25A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 173
ASP A 192
GLY A 113
SER A 114
GLU A 135
 SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-2.9A)
 1.11A 5hfjE-2b25A:
3.4		 5hfjE-2b25A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 ASP A 173
ASP A 192
GLY A 113
SER A 114
GLU A 135
 SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.8A)
SAM  A 601 (-2.9A)
 0.99A 5hfjF-2b25A:
3.6		 5hfjF-2b25A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.68A 5ikmA-2b25A:
8.0		 5ikmA-2b25A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 5kqsA-2b25A:
8.4		 5kqsA-2b25A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 192
LEU A 119
SER A 133
GLY A  83
LEU A 143
 SAM  A 601 (-3.5A)
None
None
None
None
 1.23A 5m5cE-2b25A:
2.5		 5m5cE-2b25A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		4 / 5 THR A 320
HIS A 319
ALA A 321
ASP A  91
 None
 1.24A 5mfxA-2b25A:
2.0		 5mfxA-2b25A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.67A 5njvA-2b25A:
8.5		 5njvA-2b25A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.67A 5njvB-2b25A:
8.5		 5njvB-2b25A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.66A 5wz2A-2b25A:
8.4		 5wz2A-2b25A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 111
GLY A 113
GLY A 116
ASP A 173
ASP A 192
 SAM  A 601 (-2.9A)
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-3.4A)
SAM  A 601 (-3.5A)
 0.62A 5wz2B-2b25A:
8.5		 5wz2B-2b25A:
22.71