SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b2a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b2a TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 LEU A  71
LEU A  30
VAL A 172
GLY A 171
 None
 0.84A 2po5A-2b2aA:
undetectable		 2po5A-2b2aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b2a TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 8 LEU A  71
LEU A  30
VAL A 172
GLY A 171
 None
 0.87A 2po5B-2b2aA:
undetectable		 2po5B-2b2aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2b2a TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		3 / 3 LYS A  13
GLN A 176
ASN A 175
 None
 0.91A 5l2tA-2b2aA:
undetectable		 5l2tA-2b2aA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2b2a TELOMERASE REVERSE
TRANSCRIPTASE
(Tetrahymena
thermophila) 		4 / 5 LEU A  36
PHE A  59
LEU A 139
PHE A 148
 None
 1.00A 5x19C-2b2aA:
undetectable
5x19J-2b2aA:
undetectable		 5x19C-2b2aA:
21.99
5x19J-2b2aA:
13.92