SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b2c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLY A 118
GLY A 120
GLY A 121
ASP A 141
VAL A 144
 None
 0.70A 1n2xB-2b2cA:
12.6		 1n2xB-2b2cA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 GLY A 117
GLY A 120
GLY A 121
LEU A 123
 None
 0.53A 1qzzA-2b2cA:
11.5		 1qzzA-2b2cA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLY A 120
GLY A 121
ILE A 140
ASP A 141
GLY A 171
 None
 0.69A 1sqfA-2b2cA:
9.2		 1sqfA-2b2cA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 TRP A  43
GLY A  45
ASP A  16
THR A  10
 None
 1.05A 2aouA-2b2cA:
11.2		 2aouA-2b2cA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 7 TRP A  43
GLY A  45
ASP A  16
THR A  10
 None
 1.06A 2aouB-2b2cA:
11.3		 2aouB-2b2cA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 8 PHE A 238
LEU A 235
LEU A 218
LEU A 208
 None
 0.98A 2bfpB-2b2cA:
4.8		 2bfpB-2b2cA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLY A 120
GLY A 121
ALA A  99
GLY A 116
ASP A 188
 None
 0.97A 2pkkA-2b2cA:
2.4		 2pkkA-2b2cA:
24.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLN A  95
HIS A 100
ASP A 119
GLU A 139
ILE A 114
 None
 1.38A 3b7pA-2b2cA:
37.8		 3b7pA-2b2cA:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 TRP A  43
ASP A 119
ASP A 188
GLU A 223
SER A 224
PRO A 257
 None
 0.91A 3b7pC-2b2cA:
38.4		 3b7pC-2b2cA:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 TRP A  43
TYR A  94
ASP A 188
SER A 224
PRO A 257
 None
 1.03A 3b7pC-2b2cA:
38.4		 3b7pC-2b2cA:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLN A  64
ILE A 140
ASP A 141
VAL A 144
GLY A 171
 None
 0.74A 3bwcA-2b2cA:
37.1		 3bwcA-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		6 / 12 GLN A  64
TYR A  94
GLY A 117
ASP A 141
VAL A 144
GLN A 221
 None
 1.11A 3bwcA-2b2cA:
37.1		 3bwcA-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLN A  64
TYR A  94
ILE A 115
GLY A 116
ASP A 141
VAL A 144
GLN A 221
 None
 0.82A 3bwcA-2b2cA:
37.1		 3bwcA-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 GLN A  64
TYR A  94
ILE A 115
GLY A 116
ILE A 140
ASP A 141
VAL A 144
 None
 0.81A 3bwcA-2b2cA:
37.1		 3bwcA-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 LEU A  80
ILE A 115
GLY A 116
ASP A 119
ASP A 141
VAL A 144
ASP A 188
GLN A 221
 None
 0.80A 3bwcB-2b2cA:
37.1		 3bwcB-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 LEU A  80
ILE A 115
GLY A 116
ASP A 119
ILE A 140
ASP A 141
VAL A 144
ASP A 188
 None
 0.59A 3bwcB-2b2cA:
37.1		 3bwcB-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		7 / 12 LEU A  80
TYR A  94
GLY A 117
ASP A 141
VAL A 144
ASP A 188
GLN A 221
 None
 1.39A 3bwcB-2b2cA:
37.1		 3bwcB-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 LEU A  80
TYR A  94
ILE A 115
GLY A 116
ASP A 141
VAL A 144
ASP A 188
GLN A 221
 None
 0.88A 3bwcB-2b2cA:
37.1		 3bwcB-2b2cA:
42.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		8 / 12 LEU A  80
TYR A  94
ILE A 115
GLY A 116
ILE A 140
ASP A 141
VAL A 144
ASP A 188
 None
 0.87A 3bwcB-2b2cA:
37.1		 3bwcB-2b2cA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 5 LEU A 212
LEU A 208
LEU A 113
MET A 103
 None
 1.02A 3vhuA-2b2cA:
undetectable		 3vhuA-2b2cA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 MET A 261
LEU A  98
MET A 137
VAL A 126
 None
 1.00A 4okbA-2b2cA:
undetectable		 4okbA-2b2cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		3 / 3 SER A 251
TYR A 263
ASP A  90
 None
 0.86A 4rp8C-2b2cA:
undetectable		 4rp8C-2b2cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLN A  85
GLY A 259
SER A 260
TYR A 256
GLU A 223
 None
 1.49A 4rv6A-2b2cA:
undetectable		 4rv6A-2b2cA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 11 GLN A  85
GLY A 259
SER A 260
TYR A 256
GLU A 223
 None
 1.49A 4rv6B-2b2cA:
undetectable		 4rv6B-2b2cA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		4 / 6 CYH A 157
ASN A 290
LEU A 291
GLU A 125
 None
 1.36A 4wcxC-2b2cA:
undetectable		 4wcxC-2b2cA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 PHE A 159
LEU A 175
ILE A 115
GLY A 116
ILE A 114
 None
 1.27A 5ifuA-2b2cA:
undetectable		 5ifuA-2b2cA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLN A  64
GLY A 116
ILE A 140
ASP A 141
VAL A 144
 None
 0.49A 6bq4A-2b2cA:
30.9		 6bq4A-2b2cA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 GLN A  64
GLY A 116
ILE A 140
ASP A 141
VAL A 144
 None
 0.41A 6bq4B-2b2cA:
31.0		 6bq4B-2b2cA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2b2c SPERMIDINE SYNTHASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 115
GLY A 116
GLY A 118
ILE A 140
ASP A 141
 None
 0.72A 6iftA-2b2cA:
9.2		 6iftA-2b2cA:
24.63