SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b2i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		3 / 3 MET A  39
LEU A  42
SER A  43
 None
 0.68A 1ee2A-2b2iA:
undetectable		 1ee2A-2b2iA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA8_0
(MINI-GRAMICIDIN A)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 5 VAL A 345
TRP A 135
ALA A 346
TRP A 141
 None
 1.40A 1kqeA-2b2iA:
undetectable
1kqeE-2b2iA:
undetectable		 1kqeA-2b2iA:
6.71
1kqeE-2b2iA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB8_0
(MINI-GRAMICIDIN A)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 4 VAL A 345
TRP A 135
ALA A 346
TRP A 141
 None
 1.40A 1kqeB-2b2iA:
undetectable
1kqeD-2b2iA:
undetectable		 1kqeB-2b2iA:
6.71
1kqeD-2b2iA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD8_0
(MINI-GRAMICIDIN A)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 4 ALA A 346
TRP A 141
VAL A 345
TRP A 135
 None
 1.41A 1kqeB-2b2iA:
undetectable
1kqeD-2b2iA:
undetectable		 1kqeB-2b2iA:
6.71
1kqeD-2b2iA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 149
TRP A 137
PHE A 266
SER A 208
 None
 0.98A 1rqpB-2b2iA:
undetectable		 1rqpB-2b2iA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 149
TRP A 137
PHE A 266
SER A 208
 None
 1.01A 1rqpC-2b2iA:
undetectable		 1rqpC-2b2iA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 149
TRP A 137
PHE A 266
SER A 208
 None
 0.97A 1rqpA-2b2iA:
undetectable		 1rqpA-2b2iA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		3 / 3 ALA A 303
VAL A 282
TRP A 311
 None
 0.94A 1tkqA-2b2iA:
undetectable		 1tkqA-2b2iA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 260
LEU A 257
ALA A 264
GLY A 206
TRP A 201
 None
 1.29A 2a58A-2b2iA:
undetectable
2a58B-2b2iA:
undetectable		 2a58A-2b2iA:
18.78
2a58B-2b2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 197
ALA A 227
GLY A 252
SER A 251
HIS A 305
 None
 1.22A 2a58A-2b2iA:
undetectable
2a58B-2b2iA:
undetectable		 2a58A-2b2iA:
18.78
2a58B-2b2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 260
LEU A 257
ALA A 264
GLY A 206
TRP A 201
 None
 1.28A 2a58B-2b2iA:
undetectable
2a58C-2b2iA:
undetectable		 2a58B-2b2iA:
18.78
2a58C-2b2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 197
ALA A 227
GLY A 252
SER A 251
HIS A 305
 None
 1.23A 2a58B-2b2iA:
undetectable
2a58C-2b2iA:
undetectable		 2a58B-2b2iA:
18.78
2a58C-2b2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 260
LEU A 257
ALA A 264
GLY A 206
TRP A 201
 None
 1.29A 2a58D-2b2iA:
undetectable
2a58E-2b2iA:
undetectable		 2a58D-2b2iA:
18.78
2a58E-2b2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 197
ALA A 227
GLY A 252
SER A 251
HIS A 305
 None
 1.23A 2a58D-2b2iA:
undetectable
2a58E-2b2iA:
undetectable		 2a58D-2b2iA:
18.78
2a58E-2b2iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 304
GLY A 248
ILE A 249
LEU A 257
 None
 0.77A 2o4nB-2b2iA:
undetectable		 2o4nB-2b2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 257
ILE A 304
GLY A 248
ILE A 249
 None
 0.75A 2o4nB-2b2iA:
undetectable		 2o4nB-2b2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 7 SER A 160
PHE A 204
ILE A 103
GLY A 312
 None
 0.74A 2v0mC-2b2iA:
undetectable		 2v0mC-2b2iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 8 ASP A 149
TRP A 137
PHE A 266
SER A 208
 None
 0.93A 2v7uA-2b2iA:
undetectable		 2v7uA-2b2iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 7 ASP A 149
TRP A 137
PHE A 266
SER A 208
 None
 0.95A 2v7uB-2b2iA:
undetectable		 2v7uB-2b2iA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 6 ALA A  98
ALA A 102
THR A 105
PHE A 117
 None
 0.77A 2xfhA-2b2iA:
undetectable		 2xfhA-2b2iA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 318
GLY A 312
SER A 313
LEU A 319
ALA A 255
 None
 1.08A 2yvlA-2b2iA:
undetectable		 2yvlA-2b2iA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ASN A  35
MET A  39
LEU A 104
VAL A 363
LEU A 369
 None
 1.24A 3a51D-2b2iA:
undetectable		 3a51D-2b2iA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 8 GLY A  29
ALA A  28
GLY A 193
ILE A 192
ILE A  40
 None
 1.10A 3ekpA-2b2iA:
undetectable		 3ekpA-2b2iA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 6 PHE A 117
ILE A 101
ALA A 102
ALA A 301
 None
 1.07A 3mdrB-2b2iA:
undetectable		 3mdrB-2b2iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 8 PHE A  89
PHE A  63
PHE A  96
ALA A  97
THR A 100
 None
 1.37A 3t3sD-2b2iA:
undetectable		 3t3sD-2b2iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 5 HIS A 305
SER A 160
THR A 100
ASP A 296
 None
 1.43A 3tm4B-2b2iA:
undetectable		 3tm4B-2b2iA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 325
ALA A 263
ASN A 334
LEU A 337
GLY A 146
 None
 1.21A 4r38B-2b2iA:
undetectable		 4r38B-2b2iA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 325
VAL A 324
GLY A 329
TYR A 327
ILE A 318
 None
 1.43A 4xucA-2b2iA:
undetectable		 4xucA-2b2iA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 8 LEU A 369
GLY A 368
ALA A 360
MET A 169
GLY A 172
 None
 1.20A 4zauA-2b2iA:
undetectable		 4zauA-2b2iA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 9 TRP A 135
ILE A 158
THR A 349
SER A 347
ASP A 149
 None
 1.50A 5alcH-2b2iA:
0.0		 5alcH-2b2iA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 8 VAL A 222
ALA A 272
GLY A 276
GLY A 312
 None
 0.85A 5e26C-2b2iA:
undetectable
5e26D-2b2iA:
undetectable		 5e26C-2b2iA:
23.30
5e26D-2b2iA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 256
TYR A  27
GLY A 309
THR A 261
LEU A 257
 None
 1.16A 5hg0A-2b2iA:
undetectable		 5hg0A-2b2iA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 279
VAL A 282
ILE A 318
VAL A 314
ALA A 259
 None
 1.01A 5nukA-2b2iA:
undetectable		 5nukA-2b2iA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		4 / 6 PHE A 202
PHE A 204
ILE A 260
THR A 261
 None
 1.10A 5vceA-2b2iA:
0.2		 5vceA-2b2iA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2b2i AMMONIUM TRANSPORTER
(Archaeoglobus
fulgidus) 		3 / 3 PHE A 177
ARG A 290
ALA A 109
 None
 0.98A 6ecfB-2b2iA:
undetectable		 6ecfB-2b2iA:
20.92