SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 PHE A 264
PHE A 122
LEU A  92
PHE A 265
 None
 1.03A 1wrlE-2b2nA:
undetectable		 1wrlE-2b2nA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 LEU A 106
LEU A 272
PHE A 273
ILE A  45
LEU A 327
 None
 1.14A 2oipD-2b2nA:
undetectable		 2oipD-2b2nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 LEU A 106
LEU A 272
PHE A 273
ILE A  45
LEU A 327
 None
 1.12A 2oipE-2b2nA:
undetectable		 2oipE-2b2nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.54A 2po5B-2b2nA:
undetectable		 2po5B-2b2nA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.50A 2po7B-2b2nA:
undetectable		 2po7B-2b2nA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 HIS A 120
TYR A 275
LEU A 272
VAL A 108
LEU A 212
 None
 1.49A 2prgB-2b2nA:
0.0		 2prgB-2b2nA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 4 TYR A 162
LEU A 171
LEU A 169
HIS A 152
 None
 1.42A 2x7hB-2b2nA:
undetectable		 2x7hB-2b2nA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 4 LEU A 106
GLN A  97
THR A  94
THR A 280
 None
 1.49A 2zj0D-2b2nA:
undetectable		 2zj0D-2b2nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 12 LEU A 106
LEU A 272
PHE A 273
ILE A  45
LEU A 327
 None
 1.15A 3hj3B-2b2nA:
undetectable		 3hj3B-2b2nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 GLU A 304
LEU A 300
LEU A  76
 None
 0.75A 3ohtA-2b2nA:
undetectable		 3ohtA-2b2nA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 GLU A 304
LEU A 300
LEU A  76
 None
 0.76A 3ohtB-2b2nA:
undetectable		 3ohtB-2b2nA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 PRO A 213
ILE A 257
TRP A  73
PHE A 122
 None
 1.25A 3topB-2b2nA:
undetectable		 3topB-2b2nA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		3 / 3 ARG A 116
GLN A 318
GLU A 326
 None
 0.90A 4tvtA-2b2nA:
undetectable		 4tvtA-2b2nA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 ILE A  88
HIS A 215
LEU A  92
GLY A 160
 None
 1.00A 4z69A-2b2nA:
undetectable		 4z69A-2b2nA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 5 PRO A 109
ALA A  46
ALA A  52
LEU A 106
 None
 0.74A 5jncD-2b2nA:
undetectable		 5jncD-2b2nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		5 / 8 VAL A 105
ILE A  59
ALA A  28
VAL A 283
HIS A  38
 None
 1.37A 5l94A-2b2nA:
undetectable		 5l94A-2b2nA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 7 VAL A  43
PHE A 276
LEU A 113
THR A 112
 None
 0.87A 5m78A-2b2nA:
undetectable		 5m78A-2b2nA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR
(Escherichia
coli) 		4 / 6 ASP A 146
GLN A 144
LEU A 136
PHE A 184
 None
 1.27A 6ekuA-2b2nA:
undetectable		 6ekuA-2b2nA:
18.21