SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b2t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 9 ARG A  23
LEU A  61
TRP A  64
TRP A  67
THR A  73
TRP A  74
 None
 0.44A 4x3uA-2b2tA:
5.8		 4x3uA-2b2tA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_2
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 10 ARG A  23
LEU A  61
TRP A  64
TRP A  67
THR A  73
TRP A  74
 None
 0.49A 4x3uB-2b2tA:
7.4		 4x3uB-2b2tA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 132
PHE A 175
ILE A  36
GLU A  40
 None
 1.27A 4zzcA-2b2tA:
undetectable
4zzcB-2b2tA:
undetectable		 4zzcA-2b2tA:
17.55
4zzcB-2b2tA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 132
PHE A 175
ILE A  36
GLU A  40
 None
 1.21A 4zzcB-2b2tA:
undetectable
4zzcC-2b2tA:
undetectable		 4zzcB-2b2tA:
17.55
4zzcC-2b2tA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A 156
HIS A  69
ILE A 132
ILE A  70
 None
 1.22A 5dnuA-2b2tA:
undetectable		 5dnuA-2b2tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A 156
HIS A  69
ILE A 132
ILE A  70
 None
 1.27A 5dnvA-2b2tA:
undetectable		 5dnvA-2b2tA:
19.34