SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 7 VAL A 152
ARG A 280
ILE A 270
GLY A 229
 None
 0.87A 11gsA-2b2xA:
undetectable		 11gsA-2b2xA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 8 GLY A 221
GLY A 220
HIS A 196
VAL A 152
 None
 0.91A 1dbbH-2b2xA:
undetectable
1dbbL-2b2xA:
undetectable		 1dbbH-2b2xA:
17.99
1dbbL-2b2xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		5 / 11 VAL A 328
VAL A 325
ARG A 175
GLU A 333
ASP A 171
 None
 1.42A 1t6zA-2b2xA:
undetectable		 1t6zA-2b2xA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.12A 1v55C-2b2xH:
undetectable
1v55N-2b2xH:
undetectable
1v55P-2b2xH:
undetectable		 1v55C-2b2xH:
22.43
1v55N-2b2xH:
16.86
1v55P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		4 / 5 LEU L 183
GLY L 132
PRO L 124
VAL L 136
 None
 0.92A 2aojA-2b2xL:
undetectable		 2aojA-2b2xL:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2b2x ANTIBODY AQC2 FAB
INTEGRIN ALPHA-1
(Mus
musculus;
Rattus
norvegicus) 		4 / 7 SER L  91
GLY A 258
THR A 256
ILE A 306
 None
MG  A 400 ( 4.4A)
None
None
 0.99A 2bdmA-2b2xL:
undetectable		 2bdmA-2b2xL:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 8 MET A 225
ASP A 154
SER A 156
HIS A 261
 None
MG  A 400 (-3.2A)
MG  A 400 (-2.6A)
None
 1.34A 2bteD-2b2xA:
undetectable		 2bteD-2b2xA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 8 VAL A 152
ARG A 280
ILE A 270
GLY A 229
 None
 0.89A 2gssA-2b2xA:
undetectable		 2gssA-2b2xA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 8 VAL A 152
ARG A 280
ILE A 270
GLY A 229
 None
 0.89A 2gssB-2b2xA:
undetectable		 2gssB-2b2xA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		5 / 12 PHE A 336
ILE A 335
LEU A 331
PHE A 316
HIS A 314
 None
 1.05A 2jn3A-2b2xA:
undetectable		 2jn3A-2b2xA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		4 / 5 VAL L 136
VAL L 163
GLY L 162
TRP L 152
 None
 1.15A 2p2fA-2b2xL:
undetectable		 2p2fA-2b2xL:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 MET L 179
LEU L 140
SER H 183
VAL L 163
 None
 1.02A 2qd2A-2b2xL:
undetectable		 2qd2A-2b2xL:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.15A 2y69C-2b2xH:
undetectable
2y69N-2b2xH:
undetectable
2y69P-2b2xH:
undetectable		 2y69C-2b2xH:
22.43
2y69N-2b2xH:
16.86
2y69P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.09A 3ablA-2b2xH:
undetectable
3ablC-2b2xH:
undetectable
3ablP-2b2xH:
undetectable		 3ablA-2b2xH:
16.86
3ablC-2b2xH:
22.43
3ablP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.12A 3ablC-2b2xH:
undetectable
3ablN-2b2xH:
undetectable
3ablP-2b2xH:
undetectable		 3ablC-2b2xH:
22.43
3ablN-2b2xH:
16.86
3ablP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.07A 3abmA-2b2xH:
undetectable
3abmC-2b2xH:
undetectable
3abmP-2b2xH:
undetectable		 3abmA-2b2xH:
16.86
3abmC-2b2xH:
22.43
3abmP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.15A 3asnC-2b2xH:
undetectable
3asnN-2b2xH:
undetectable
3asnP-2b2xH:
undetectable		 3asnC-2b2xH:
22.43
3asnN-2b2xH:
16.86
3asnP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.17A 3asoA-2b2xH:
undetectable
3asoC-2b2xH:
undetectable
3asoP-2b2xH:
undetectable		 3asoA-2b2xH:
16.86
3asoC-2b2xH:
22.43
3asoP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.12A 3asoC-2b2xH:
undetectable
3asoN-2b2xH:
undetectable
3asoP-2b2xH:
undetectable		 3asoC-2b2xH:
22.43
3asoN-2b2xH:
16.86
3asoP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 8 VAL A 152
ARG A 280
ILE A 270
GLY A 229
 None
 0.85A 3n9jA-2b2xA:
undetectable		 3n9jA-2b2xA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		4 / 6 HIS L 202
GLU L 104
ASP L  17
ASP L 114
 None
 1.09A 3vywA-2b2xL:
undetectable		 3vywA-2b2xL:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		5 / 12 ILE A 283
PHE A 281
ILE A 151
ILE A 149
LEU A 147
 None
 1.10A 3w67B-2b2xA:
undetectable		 3w67B-2b2xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.13A 3wg7C-2b2xH:
undetectable
3wg7N-2b2xH:
undetectable
3wg7P-2b2xH:
undetectable		 3wg7C-2b2xH:
22.43
3wg7N-2b2xH:
16.86
3wg7P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.14A 3x2qA-2b2xH:
undetectable
3x2qC-2b2xH:
undetectable
3x2qP-2b2xH:
undetectable		 3x2qA-2b2xH:
16.86
3x2qC-2b2xH:
22.43
3x2qP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.15A 3x2qC-2b2xH:
undetectable
3x2qN-2b2xH:
undetectable
3x2qP-2b2xH:
undetectable		 3x2qC-2b2xH:
22.43
3x2qN-2b2xH:
16.86
3x2qP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU L   4
VAL L  29
THR H  33
SER H  35
GLY H  98
 None
 1.25A 4hvcB-2b2xL:
undetectable		 4hvcB-2b2xL:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		5 / 9 VAL A 150
ILE A 149
LEU A 147
ILE A 151
GLY A 332
 None
 1.08A 4kukA-2b2xA:
undetectable		 4kukA-2b2xA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 2b2x ANTIBODY AQC2 FAB
INTEGRIN ALPHA-1
(Mus
musculus;
Rattus
norvegicus) 		5 / 9 ASP H 101
VAL H  50
GLY A 220
SER A 158
GLY H  53
 MG  A 400 (-3.6A)
None
None
MG  A 400 (-2.5A)
None
 1.42A 4mmeA-2b2xH:
undetectable		 4mmeA-2b2xH:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 2b2x ANTIBODY AQC2 FAB
INTEGRIN ALPHA-1
(Mus
musculus;
Rattus
norvegicus) 		5 / 12 ASN L  93
PRO L  94
GLU A 192
VAL H  50
TYR H  58
 None
 1.38A 4xrgA-2b2xL:
0.0		 4xrgA-2b2xL:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.18A 5b1bA-2b2xH:
undetectable
5b1bC-2b2xH:
undetectable
5b1bP-2b2xH:
undetectable		 5b1bA-2b2xH:
16.86
5b1bC-2b2xH:
22.43
5b1bP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU L   4
GLY L  92
VAL L  29
SER H  35
GLY H  98
 None
 1.19A 5f9zA-2b2xL:
undetectable		 5f9zA-2b2xL:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.11A 5iy5C-2b2xH:
undetectable
5iy5N-2b2xH:
undetectable
5iy5P-2b2xH:
undetectable		 5iy5C-2b2xH:
23.19
5iy5N-2b2xH:
16.86
5iy5P-2b2xH:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		4 / 5 TYR L  70
SER L  24
ALA L  25
GLN L  28
 None
 1.19A 5n0wB-2b2xL:
undetectable		 5n0wB-2b2xL:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		4 / 5 TYR L  70
SER L  24
ALA L  25
GLN L  28
 None
 1.23A 5n4iA-2b2xL:
undetectable		 5n4iA-2b2xL:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 6 THR A 232
ASP A 231
LEU A 228
ASP A 262
 None
 1.17A 5tdzA-2b2xA:
5.9		 5tdzA-2b2xA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2b2x INTEGRIN ALPHA-1
ANTIBODY AQC2 FAB
(Rattus
norvegicus;
Mus
musculus) 		3 / 3 GLU H  64
TYR H  58
ARG A 222
 None
 0.83A 5uunA-2b2xH:
undetectable		 5uunA-2b2xH:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.08A 5w97A-2b2xH:
undetectable
5w97C-2b2xH:
undetectable
5w97c-2b2xH:
undetectable		 5w97A-2b2xH:
16.86
5w97C-2b2xH:
22.43
5w97c-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.11A 5w97C-2b2xH:
undetectable
5w97a-2b2xH:
undetectable
5w97c-2b2xH:
undetectable		 5w97C-2b2xH:
22.43
5w97a-2b2xH:
16.86
5w97c-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.12A 5wauA-2b2xH:
undetectable
5wauC-2b2xH:
undetectable
5wauc-2b2xH:
undetectable		 5wauA-2b2xH:
16.86
5wauC-2b2xH:
22.43
5wauc-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.07A 5wauC-2b2xH:
undetectable
5waua-2b2xH:
undetectable
5wauc-2b2xH:
undetectable		 5wauC-2b2xH:
22.43
5waua-2b2xH:
16.86
5wauc-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2b2x INTEGRIN ALPHA-1
ANTIBODY AQC2 FAB
(Rattus
norvegicus;
Mus
musculus) 		5 / 12 GLY H  55
SER A 156
ILE A 159
GLY H  53
GLY H  54
 None
MG  A 400 (-2.6A)
None
None
None
 1.00A 5wyqB-2b2xH:
undetectable		 5wyqB-2b2xH:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.06A 5x19A-2b2xH:
undetectable
5x19C-2b2xH:
undetectable
5x19P-2b2xH:
undetectable		 5x19A-2b2xH:
16.86
5x19C-2b2xH:
22.43
5x19P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.07A 5x1bA-2b2xH:
undetectable
5x1bC-2b2xH:
undetectable
5x1bP-2b2xH:
undetectable		 5x1bA-2b2xH:
16.86
5x1bC-2b2xH:
22.43
5x1bP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.05A 5x1fA-2b2xH:
undetectable
5x1fC-2b2xH:
undetectable
5x1fP-2b2xH:
undetectable		 5x1fA-2b2xH:
16.86
5x1fC-2b2xH:
22.43
5x1fP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		4 / 7 ASN L  30
HIS L  31
ASP H 101
GLY H 102
 None
None
MG  A 400 (-3.6A)
None
 1.03A 5x7pA-2b2xL:
undetectable		 5x7pA-2b2xL:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.12A 5xdqA-2b2xH:
undetectable
5xdqC-2b2xH:
undetectable
5xdqP-2b2xH:
undetectable		 5xdqA-2b2xH:
16.86
5xdqC-2b2xH:
22.43
5xdqP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.15A 5xdqC-2b2xH:
undetectable
5xdqN-2b2xH:
undetectable
5xdqP-2b2xH:
undetectable		 5xdqC-2b2xH:
22.43
5xdqN-2b2xH:
16.86
5xdqP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.12A 5xdxC-2b2xH:
undetectable
5xdxN-2b2xH:
undetectable
5xdxP-2b2xH:
undetectable		 5xdxC-2b2xH:
23.19
5xdxN-2b2xH:
16.86
5xdxP-2b2xH:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU L   4
VAL L  29
THR H  33
SER H  35
GLY H  98
 None
 1.24A 5xipA-2b2xL:
undetectable		 5xipA-2b2xL:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		5 / 12 LEU L   4
VAL L  29
THR H  33
SER H  35
GLY H  98
 None
 1.21A 5xiqA-2b2xL:
undetectable		 5xiqA-2b2xL:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.09A 5z84A-2b2xH:
undetectable
5z84C-2b2xH:
undetectable
5z84P-2b2xH:
undetectable		 5z84A-2b2xH:
16.86
5z84C-2b2xH:
22.43
5z84P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.09A 5z84C-2b2xH:
undetectable
5z84N-2b2xH:
undetectable
5z84P-2b2xH:
undetectable		 5z84C-2b2xH:
22.43
5z84N-2b2xH:
16.86
5z84P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.12A 5z85A-2b2xH:
undetectable
5z85C-2b2xH:
undetectable
5z85P-2b2xH:
undetectable		 5z85A-2b2xH:
16.86
5z85C-2b2xH:
22.43
5z85P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.13A 5z85C-2b2xH:
undetectable
5z85N-2b2xH:
undetectable
5z85P-2b2xH:
undetectable		 5z85C-2b2xH:
22.43
5z85N-2b2xH:
16.86
5z85P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.13A 5z86A-2b2xH:
undetectable
5z86C-2b2xH:
undetectable
5z86P-2b2xH:
undetectable		 5z86A-2b2xH:
16.86
5z86C-2b2xH:
22.43
5z86P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.13A 5z86C-2b2xH:
undetectable
5z86N-2b2xH:
undetectable
5z86P-2b2xH:
undetectable		 5z86C-2b2xH:
22.43
5z86N-2b2xH:
16.86
5z86P-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.13A 5zcoC-2b2xH:
undetectable
5zcoN-2b2xH:
undetectable
5zcoP-2b2xH:
undetectable		 5zcoC-2b2xH:
22.43
5zcoN-2b2xH:
16.86
5zcoP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.12A 5zcpA-2b2xH:
undetectable
5zcpC-2b2xH:
undetectable
5zcpP-2b2xH:
undetectable		 5zcpA-2b2xH:
16.86
5zcpC-2b2xH:
22.43
5zcpP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.12A 5zcpC-2b2xH:
undetectable
5zcpN-2b2xH:
undetectable
5zcpP-2b2xH:
undetectable		 5zcpC-2b2xH:
22.43
5zcpN-2b2xH:
16.86
5zcpP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.13A 5zcqA-2b2xH:
undetectable
5zcqC-2b2xH:
undetectable
5zcqP-2b2xH:
undetectable		 5zcqA-2b2xH:
16.86
5zcqC-2b2xH:
22.43
5zcqP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2b2x INTEGRIN ALPHA-1
(Rattus
norvegicus) 		4 / 7 GLN A 271
VAL A 269
ILE A 230
THR A 226
 None
 1.01A 6cduF-2b2xA:
undetectable
6cduG-2b2xA:
undetectable		 6cduF-2b2xA:
20.76
6cduG-2b2xA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 2b2x ANTIBODY AQC2 FAB
(Mus
musculus) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 None
 0.14A 6cjkB-2b2xH:
25.7		 6cjkB-2b2xH:
62.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
TRP L  90
 None
 1.15A 6nknC-2b2xH:
undetectable
6nknN-2b2xH:
undetectable
6nknP-2b2xH:
undetectable		 6nknC-2b2xH:
22.43
6nknN-2b2xH:
16.86
6nknP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x INTEGRIN ALPHA-1
ANTIBODY AQC2 FAB
(Rattus
norvegicus;
Mus
musculus) 		4 / 8 LEU H   4
THR H  33
TYR H  32
HIS A 261
 None
 1.13A 6nknC-2b2xH:
undetectable
6nknN-2b2xH:
undetectable
6nknP-2b2xH:
undetectable		 6nknC-2b2xH:
22.43
6nknN-2b2xH:
16.86
6nknP-2b2xH:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2b2x ANTIBODY AQC2 FAB
ANTIBODY AQC2 FAB
(Mus
musculus;
Mus
musculus) 		4 / 7 THR H  33
TYR H  32
TRP L  90
LEU H   4
 None
 1.16A 6nmfA-2b2xH:
undetectable
6nmfC-2b2xH:
undetectable
6nmfP-2b2xH:
undetectable		 6nmfA-2b2xH:
16.86
6nmfC-2b2xH:
22.43
6nmfP-2b2xH:
22.43