SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 9 ALA A 254
THR A 227
HIS A 223
GLY A 222
THR A 207
 None
 1.20A 1c9sQ-2b30A:
undetectable
1c9sR-2b30A:
undetectable		 1c9sQ-2b30A:
13.62
1c9sR-2b30A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 10 GLY A 222
THR A 207
ALA A 254
THR A 227
HIS A 223
 None
 1.16A 1c9sL-2b30A:
undetectable
1c9sV-2b30A:
undetectable		 1c9sL-2b30A:
13.62
1c9sV-2b30A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		4 / 5 GLU A 217
THR A 211
HIS A 215
LEU A 156
 None
 1.37A 1d4fC-2b30A:
3.3		 1d4fC-2b30A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 10 VAL A 296
PHE A  79
VAL A  46
VAL A  64
LEU A 293
 None
 1.07A 1fe2A-2b30A:
undetectable		 1fe2A-2b30A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 9 ALA A 254
THR A 227
HIS A 223
GLY A 222
THR A 207
 None
 1.20A 1gtfR-2b30A:
undetectable
1gtfS-2b30A:
undetectable		 1gtfR-2b30A:
13.62
1gtfS-2b30A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 10 ALA A 254
VAL A  95
MET A 255
LEU A  31
ASP A 248
 None
None
None
None
CA  A 302 (-3.0A)
 1.20A 1rlbE-2b30A:
undetectable		 1rlbE-2b30A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		3 / 3 SER A  65
VAL A 243
LEU A  29
 None
 0.65A 1yajG-2b30A:
undetectable		 1yajG-2b30A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		3 / 3 HIS A 215
ILE A 195
LEU A 132
 None
 0.61A 2kceA-2b30A:
undetectable		 2kceA-2b30A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 10 GLU A 142
ILE A 101
ASP A 104
GLY A 107
TYR A 236
 None
 1.49A 2tsrC-2b30A:
undetectable		 2tsrC-2b30A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		3 / 3 SER A 262
ALA A 264
VAL A 265
 None
 0.40A 4x20C-2b30A:
3.9		 4x20C-2b30A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 12 ILE A 115
TYR A 120
GLU A 217
SER A  71
ILE A 101
 None
 1.38A 5igwA-2b30A:
undetectable		 5igwA-2b30A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2b30 PVIVAX HYPOTHETICAL
PROTEIN
(Plasmodium
vivax) 		5 / 12 PHE A  34
ILE A  66
PHE A  79
ALA A  53
ALA A 288
 None
 1.11A 5vceA-2b30A:
undetectable		 5vceA-2b30A:
22.15