SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2b34 MAR1 RIBONUCLEASE
(Caenorhabditis
elegans) 		4 / 8 ARG A 144
ASP A 190
VAL A 136
ASP A 134
 None
 1.13A 4xqgA-2b34A:
5.4		 4xqgA-2b34A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2b34 MAR1 RIBONUCLEASE
(Caenorhabditis
elegans) 		4 / 8 ARG A 144
ASP A 190
VAL A 136
ASP A 134
 None
 1.11A 4xqgB-2b34A:
4.9		 4xqgB-2b34A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2b34 MAR1 RIBONUCLEASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 165
ILE A 184
LEU A 183
ASP A 134
ALA A 135
 None
 1.21A 5km9B-2b34A:
undetectable		 5km9B-2b34A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 2b34 MAR1 RIBONUCLEASE
(Caenorhabditis
elegans) 		4 / 8 ILE A  37
THR A  38
THR A 191
SER A 161
 None
 1.05A 6c06C-2b34A:
undetectable		 6c06C-2b34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2b34 MAR1 RIBONUCLEASE
(Caenorhabditis
elegans) 		4 / 4 VAL A 194
GLY A 192
ASP A 190
ASP A 134
 None
 1.36A 6cjkC-2b34A:
undetectable		 6cjkC-2b34A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2b34 MAR1 RIBONUCLEASE
(Caenorhabditis
elegans) 		5 / 11 VAL A 132
THR A 160
LEU A  17
ALA A 163
VAL A 129
 None
 1.29A 6dryA-2b34A:
undetectable		 6dryA-2b34A:
21.03