SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b3b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 4 GLY A 390
LEU A 392
GLY A 388
ARG A 391
 None
 1.10A 1j7kA-2b3bA:
undetectable		 1j7kA-2b3bA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 385
PHE A 356
ASN A 378
 None
 0.80A 1sg9B-2b3bA:
undetectable		 1sg9B-2b3bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 207
PHE A 145
PRO A 267
THR A 269
 None
 1.36A 2q6oB-2b3bA:
2.1		 2q6oB-2b3bA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 389
ARG A 391
ASP A 385
ALA A 384
 None
 1.13A 2qhfA-2b3bA:
undetectable		 2qhfA-2b3bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A 232
SER A 223
TRP A 224
GLY A 247
ALA A 245
 None
None
GLC  A2605 ( 4.5A)
None
None
 1.44A 2x2iB-2b3bA:
undetectable		 2x2iB-2b3bA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 LEU A  55
VAL A  77
ARG A  80
 None
 0.82A 3b0wB-2b3bA:
undetectable		 3b0wB-2b3bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 7 ARG A 210
VAL A 363
LEU A 172
ILE A 366
 None
 0.97A 3gp0A-2b3bA:
undetectable		 3gp0A-2b3bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 211
SER A 266
LEU A 131
LEU A 161
 None
 0.74A 3kk6A-2b3bA:
undetectable		 3kk6A-2b3bA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 VAL A 211
SER A 266
LEU A 131
LEU A 161
 None
 0.64A 3kk6B-2b3bA:
undetectable		 3kk6B-2b3bA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A 182
TRP A 186
VAL A 343
 None
 0.71A 3n62B-2b3bA:
undetectable		 3n62B-2b3bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A 182
TRP A 186
VAL A 343
 None
 0.70A 3n65B-2b3bA:
undetectable		 3n65B-2b3bA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A 182
TRP A 186
VAL A 343
 None
 0.72A 3n66B-2b3bA:
undetectable		 3n66B-2b3bA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A  28
TYR A  24
LEU A  87
TRP A  93
 None
 1.10A 3uzzB-2b3bA:
undetectable		 3uzzB-2b3bA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A  68
ILE A 105
VAL A  65
SER A 113
 None
 1.25A 4d33B-2b3bA:
undetectable		 4d33B-2b3bA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 297
TRP A  93
GLY A 300
 None
 1.03A 4e7cA-2b3bA:
undetectable		 4e7cA-2b3bA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A  73
GLY A  68
LEU A 104
TYR A 107
 None
 0.65A 4fgzA-2b3bA:
undetectable		 4fgzA-2b3bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A  73
GLY A  68
LEU A 104
TYR A 107
 None
 0.64A 4fgzB-2b3bA:
undetectable		 4fgzB-2b3bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 PHE A 360
PHE A 356
ALA A 377
ALA A 380
LEU A 194
 None
 1.12A 4j6dB-2b3bA:
undetectable		 4j6dB-2b3bA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 11 THR A 250
THR A 251
THR A 252
GLY A 313
ALA A 246
 None
 1.39A 4qwuV-2b3bA:
undetectable
4qwub-2b3bA:
undetectable		 4qwuV-2b3bA:
19.22
4qwub-2b3bA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 11 THR A 250
THR A 251
THR A 252
GLY A 313
ALA A 246
 None
 1.39A 4qwuH-2b3bA:
undetectable
4qwuN-2b3bA:
undetectable		 4qwuH-2b3bA:
19.22
4qwuN-2b3bA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 8 THR A 148
CYH A 214
TRP A 142
LEU A 146
 None
 1.38A 5kxiD-2b3bA:
undetectable
5kxiE-2b3bA:
undetectable		 5kxiD-2b3bA:
18.25
5kxiE-2b3bA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A 329
SER A 314
TRP A 125
 None
 0.85A 5n8jB-2b3bA:
undetectable		 5n8jB-2b3bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A 329
SER A 314
TRP A 125
 None
 0.88A 5n8jA-2b3bA:
undetectable		 5n8jA-2b3bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 TYR A 329
SER A 314
TRP A 125
 None
 0.93A 5n8jD-2b3bA:
undetectable		 5n8jD-2b3bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 298
ASP A 278
ASN A  35
ILE A   5
HIS A 119
 None
GLC  A2605 (-2.7A)
None
None
GLC  A2605 ( 4.7A)
 1.25A 5uh6C-2b3bA:
0.0		 5uh6C-2b3bA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 298
ASP A 278
ASN A  35
ILE A   5
HIS A 119
 None
GLC  A2605 (-2.7A)
None
None
GLC  A2605 ( 4.7A)
 1.20A 5uhgC-2b3bA:
0.0		 5uhgC-2b3bA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		3 / 3 GLY A 182
TRP A 186
VAL A 343
 None
 0.68A 5vuoB-2b3bA:
undetectable		 5vuoB-2b3bA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2b3b GLUCOSE-BINDING
PROTEIN
(Thermus
thermophilus) 		4 / 6 GLN A 226
GLU A 165
TRP A 224
ALA A 227
 None
None
GLC  A2605 ( 4.5A)
None
 1.33A 6f6jC-2b3bA:
undetectable
6f6jD-2b3bA:
undetectable		 6f6jC-2b3bA:
23.04
6f6jD-2b3bA:
23.04