SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b3d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		3 / 3 ARG A  54
GLY A  29
ASP A  33
 None
FAD  A1205 (-3.0A)
None
 0.56A 1kf6A-2b3dA:
2.1
1kf6B-2b3dA:
undetectable		 1kf6A-2b3dA:
15.33
1kf6B-2b3dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		5 / 12 MET A  78
PRO A  79
VAL A  96
TYR A  59
ASP A  95
 None
FAD  A1205 (-4.2A)
None
None
None
 1.40A 1mrlB-2b3dA:
0.0
1mrlC-2b3dA:
0.0		 1mrlB-2b3dA:
21.59
1mrlC-2b3dA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		5 / 12 LEU A  35
THR A  36
ALA A  39
LEU A 199
ILE A 178
 None
 0.93A 1qknA-2b3dA:
undetectable		 1qknA-2b3dA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		3 / 3 LEU A 160
HIS A 163
LYS A 164
 None
 0.84A 1y7iA-2b3dA:
3.7		 1y7iA-2b3dA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 7 PHE A 177
THR A 135
VAL A 188
VAL A  38
 None
FAD  A1205 (-3.7A)
FAD  A1205 ( 4.6A)
None
 1.03A 2qbnA-2b3dA:
undetectable		 2qbnA-2b3dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		3 / 3 PHE A 162
ASN A 166
PHE A  97
 None
 1.06A 2zbuD-2b3dA:
2.1		 2zbuD-2b3dA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		5 / 8 PHE A  97
LEU A  16
VAL A  74
VAL A 125
LEU A 104
 None
 1.27A 2zujA-2b3dA:
undetectable		 2zujA-2b3dA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		5 / 12 LEU A  43
LEU A  16
ILE A  52
ILE A  75
PHE A  68
 None
 1.38A 4a79B-2b3dA:
undetectable		 4a79B-2b3dA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		5 / 12 SER A  27
PHE A 177
ASP A  33
ALA A  39
VAL A  38
 FAD  A1205 (-2.9A)
None
None
None
None
 1.05A 4dx5B-2b3dA:
undetectable		 4dx5B-2b3dA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 7 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.84A 4eq4A-2b3dA:
2.1		 4eq4A-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 8 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.78A 4eq4B-2b3dA:
2.0		 4eq4B-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 7 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.83A 4eqlA-2b3dA:
2.2		 4eqlA-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 7 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.83A 4eqlB-2b3dA:
undetectable		 4eqlB-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 6 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.85A 4l39A-2b3dA:
undetectable		 4l39A-2b3dA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2b3d MODULATOR OF DRUG
ACTIVITY B
(Escherichia
coli) 		4 / 7 LEU A 199
TYR A 195
ILE A  17
GLY A  41
 None
 0.82A 4l39B-2b3dA:
1.8		 4l39B-2b3dA:
16.50