SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_B_TRPB81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 9	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.36A	1c9sA-2b3oA: undetectable 1c9sB-2b3oA: undetectable	1c9sA-2b3oA: 10.15 1c9sB-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1C9S_C_TRPC81_0 (TRP RNA-BINDING ATTENUATION PROTEIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.36A	1c9sB-2b3oA: undetectable 1c9sC-2b3oA: undetectable	1c9sB-2b3oA: 10.15 1c9sC-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JFF_B_TA1B601_1 (TUBULIN BETA CHAIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	1jffB-2b3oA: undetectable	1jffB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MZ9_D_VDYD1001_5 (CARTILAGE OLIGOMERIC MATRIX PROTEIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	THR A 132 LEU A 150 VAL A 164	None	0.64A	1mz9E-2b3oA: undetectable	1mz9E-2b3oA: 7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QZR_B_CDXB901_1 (DNA TOPOISOMERASE II)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 7	THR A 487 ASN A 258 LEU A 251 GLN A 489	None	0.96A	1qzrA-2b3oA: undetectable	1qzrA-2b3oA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UTD_M_TRPM81_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 11	GLY A 458 ALA A 455 ILE A 457 ARG A 358 THR A 351	None	1.36A	1utdM-2b3oA: undetectable 1utdN-2b3oA: undetectable	1utdM-2b3oA: 10.15 1utdN-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAT_A_FK5A108_1 (FK506 BINDING PROTEIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 11	VAL A 451 ILE A 450 LEU A 395 ILE A 409 PHE A 335	None	1.35A	1yatA-2b3oA: undetectable	1yatA-2b3oA: 12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HXF_B_TA1B601_1 (TUBULIN BETA CHAIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	2hxfB-2b3oA: undetectable	2hxfB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HXH_B_TA1B601_1 (TUBULIN BETA CHAIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	2hxhB-2b3oA: undetectable	2hxhB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P4N_B_TA1B601_1 (TUBULIN BETA CHAIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	2p4nB-2b3oA: undetectable	2p4nB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLC_A_GLYA333_0 (CHOLOYLGLYCINE HYDROLASE)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	ASN A 274 ASN A 303 ARG A 495	None	0.85A	2rlcA-2b3oA: undetectable	2rlcA-2b3oA: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WBE_B_TA1B1439_1 (TUBULIN BETA-2B CHAIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	2wbeB-2b3oA: undetectable	2wbeB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1376_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 8	LEU A 150 LEU A 124 HIS A 112 MET A 115	None	1.04A	2wekA-2b3oA: undetectable	2wekA-2b3oA: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	ARG A 286 ASP A 334 ASN A 270	None	0.79A	2zzmA-2b3oA: undetectable	2zzmA-2b3oA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCO_B_TA1B601_1 (BOVINE BETA TUBULIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	3dcoB-2b3oA: undetectable	3dcoB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EDL_B_TA1B601_1 (BETA TUBULIN)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.19A	3edlB-2b3oA: undetectable	3edlB-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H52_B_486B1_2 (GLUCOCORTICOID RECEPTOR)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	GLY A 458 GLY A 461 GLN A 500 VAL A 499 ILE A 508	None	1.26A	3h52B-2b3oA: undetectable	3h52B-2b3oA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IZ0_B_TA1B820_1 (BETA TUBULIN, CHAIN B FROM PDB 1JFF)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	LEU A 75 PHE A 39 LEU A 72 THR A 71 GLY A 58	None	1.17A	3iz0B-2b3oA: undetectable	3iz0B-2b3oA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T7V_A_SAMA992_0 (METHYLORNITHINE SYNTHASE PYLB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	GLY A 497 GLY A 458 LEU A 469 MET A 468 VAL A 491	None	1.21A	3t7vA-2b3oA: undetectable	3t7vA-2b3oA: 22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX7_D_H4BD600_1 (NITRIC OXIDE SYNTHASE, INDUCIBLE)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 7	PHE A 60 GLU A 67 ARG A 358 ILE A 279	None	1.45A	4cx7C-2b3oA: 0.5 4cx7D-2b3oA: undetectable	4cx7C-2b3oA: 21.92 4cx7D-2b3oA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LTW_A_486A302_1 (ANCESTRAL STEROID RECEPTOR 2)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	VAL A 465 LEU A 251 ILE A 508 ILE A 512 ALA A 221	None	1.03A	4ltwA-2b3oA: undetectable	4ltwA-2b3oA: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 8	THR A 177 GLY A 173 GLY A 174 ASP A 185	None	0.72A	4qvvK-2b3oA: undetectable 4qvvL-2b3oA: undetectable	4qvvK-2b3oA: 16.89 4qvvL-2b3oA: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 8	THR A 177 GLY A 173 GLY A 174 ASP A 185	None	0.72A	4qvvY-2b3oA: undetectable 4qvvZ-2b3oA: undetectable	4qvvY-2b3oA: 16.89 4qvvZ-2b3oA: 16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UIN_H_QI9H1226_0 (FAB 314.3)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	HIS A 193 THR A 197 GLU A 182 PHE A 184 GLY A 179	None	1.14A	4uinH-2b3oA: undetectable 4uinL-2b3oA: undetectable	4uinH-2b3oA: 19.14 4uinL-2b3oA: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DSG_A_0HKA1201_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYS IN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	ASN A 101 LEU A 18 PHE A 5	None	0.77A	5dsgA-2b3oA: undetectable	5dsgA-2b3oA: 20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEU_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5eeuD-2b3oA: undetectable 5eeuE-2b3oA: undetectable	5eeuD-2b3oA: 10.15 5eeuE-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEV_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5eevD-2b3oA: undetectable 5eevE-2b3oA: undetectable	5eevD-2b3oA: 10.15 5eevE-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEW_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5eewD-2b3oA: undetectable 5eewE-2b3oA: undetectable	5eewD-2b3oA: 10.15 5eewE-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEX_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5eexD-2b3oA: undetectable 5eexE-2b3oA: undetectable	5eexD-2b3oA: 10.15 5eexE-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEY_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5eeyD-2b3oA: undetectable 5eeyE-2b3oA: undetectable	5eeyD-2b3oA: 10.15 5eeyE-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEZ_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5eezD-2b3oA: undetectable 5eezE-2b3oA: undetectable	5eezD-2b3oA: 10.15 5eezE-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF0_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5ef0D-2b3oA: undetectable 5ef0E-2b3oA: undetectable	5ef0D-2b3oA: 10.15 5ef0E-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF1_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5ef1D-2b3oA: undetectable 5ef1E-2b3oA: undetectable	5ef1D-2b3oA: 10.15 5ef1E-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF2_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5ef2D-2b3oA: undetectable 5ef2E-2b3oA: undetectable	5ef2D-2b3oA: 10.15 5ef2E-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF3_D_TRPD101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 10	ARG A 358 THR A 351 GLY A 458 ALA A 455 ILE A 457	None	1.37A	5ef3D-2b3oA: undetectable 5ef3E-2b3oA: undetectable	5ef3D-2b3oA: 10.15 5ef3E-2b3oA: 10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KOX_A_RFPA502_2 (PENTACHLOROPHENOL 4-MONOOXYGENASE)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	VAL A 49 ARG A 7 PRO A 31	None	0.63A	5koxA-2b3oA: undetectable	5koxA-2b3oA: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_E_PFLE409_1 (PROTON-GATED ION CHANNEL)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 8	TYR A 509 TYR A 505 ILE A 488 ILE A 466	None	0.87A	5mzrE-2b3oA: undetectable	5mzrE-2b3oA: 10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWW_A_ACAA18_1 (SCRFP-TAG,GP41)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	5 / 12	GLY A 497 SER A 496 ASN A 278 GLU A 74 LEU A 259	None	1.14A	5nwwA-2b3oA: undetectable	5nwwA-2b3oA: 6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TJY_A_BEZA304_0 (4-HYDROXY-TETRAHYDRO DIPICOLINATE REDUCTASE)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	MET A 115 GLU A 121 ARG A 136	None	1.12A	5tjyA-2b3oA: undetectable	5tjyA-2b3oA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TJZ_A_BEZA302_0 (4-HYDROXY-TETRAHYDRO DIPICOLINATE REDUCTASE)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	3 / 3	MET A 115 GLU A 121 ARG A 136	None	1.08A	5tjzA-2b3oA: undetectable	5tjzA-2b3oA: 19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AK3_B_P2EB1201_1 (PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562)	2b3o	TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6 (Homo sapiens)	4 / 5	PRO A 426 VAL A 510 GLY A 458 VAL A 422	None	0.94A	6ak3B-2b3oA: undetectable	6ak3B-2b3oA: 8.65

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1C9S_B_TRPB81_0","TRP RNA-BINDING ATTENUATION PROTEIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.36A","1c9sA-2b3oA:undetectable;1c9sB-2b3oA:undetectable","1c9sA-2b3oA:10.15;1c9sB-2b3oA:10.15"],["1C9S_C_TRPC81_0","TRP RNA-BINDING ATTENUATION PROTEIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.36A","1c9sB-2b3oA:undetectable;1c9sC-2b3oA:undetectable","1c9sB-2b3oA:10.15;1c9sC-2b3oA:10.15"],["1JFF_B_TA1B601_1","TUBULIN BETA CHAIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","1jffB-2b3oA:undetectable","1jffB-2b3oA:21.07"],["1MZ9_D_VDYD1001_5","CARTILAGE OLIGOMERIC MATRIX PROTEIN;CARTILAGE OLIGOMERIC MATRIX PROTEIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"THR A 132;LEU A 150;VAL A 164","None","0.64A","1mz9E-2b3oA:undetectable","1mz9E-2b3oA:7.09"],["1QZR_B_CDXB901_1","DNA TOPOISOMERASE II;DNA TOPOISOMERASE II","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"THR A 487;ASN A 258;LEU A 251;GLN A 489","None","0.96A","1qzrA-2b3oA:undetectable","1qzrA-2b3oA:20.82"],["1UTD_M_TRPM81_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"GLY A 458;ALA A 455;ILE A 457;ARG A 358;THR A 351","None","1.36A","1utdM-2b3oA:undetectable;1utdN-2b3oA:undetectable","1utdM-2b3oA:10.15;1utdN-2b3oA:10.15"],["1YAT_A_FK5A108_1","FK506 BINDING PROTEIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"VAL A 451;ILE A 450;LEU A 395;ILE A 409;PHE A 335","None","1.35A","1yatA-2b3oA:undetectable","1yatA-2b3oA:12.43"],["2HXF_B_TA1B601_1","TUBULIN BETA CHAIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","2hxfB-2b3oA:undetectable","2hxfB-2b3oA:21.07"],["2HXH_B_TA1B601_1","TUBULIN BETA CHAIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","2hxhB-2b3oA:undetectable","2hxhB-2b3oA:21.07"],["2P4N_B_TA1B601_1","TUBULIN BETA CHAIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","2p4nB-2b3oA:undetectable","2p4nB-2b3oA:21.07"],["2RLC_A_GLYA333_0","CHOLOYLGLYCINE HYDROLASE","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"ASN A 274;ASN A 303;ARG A 495","None","0.85A","2rlcA-2b3oA:undetectable","2rlcA-2b3oA:22.73"],["2WBE_B_TA1B1439_1","TUBULIN BETA-2B CHAIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","2wbeB-2b3oA:undetectable","2wbeB-2b3oA:21.07"],["2WEK_A_DIFA1376_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"LEU A 150;LEU A 124;HIS A 112;MET A 115","None","1.04A","2wekA-2b3oA:undetectable","2wekA-2b3oA:21.56"],["2ZZM_A_SAMA401_1","UNCHARACTERIZED PROTEIN MJ0883","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"ARG A 286;ASP A 334;ASN A 270","None","0.79A","2zzmA-2b3oA:undetectable","2zzmA-2b3oA:20.49"],["3DCO_B_TA1B601_1","BOVINE BETA TUBULIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","3dcoB-2b3oA:undetectable","3dcoB-2b3oA:21.07"],["3EDL_B_TA1B601_1","BETA TUBULIN","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.19A","3edlB-2b3oA:undetectable","3edlB-2b3oA:21.07"],["3H52_B_486B1_2","GLUCOCORTICOID RECEPTOR","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"GLY A 458;GLY A 461;GLN A 500;VAL A 499;ILE A 508","None","1.26A","3h52B-2b3oA:undetectable","3h52B-2b3oA:18.97"],["3IZ0_B_TA1B820_1","BETA TUBULIN, CHAIN B FROM PDB 1JFF","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"LEU A  75;PHE A  39;LEU A  72;THR A  71;GLY A  58","None","1.17A","3iz0B-2b3oA:undetectable","3iz0B-2b3oA:21.07"],["3T7V_A_SAMA992_0","METHYLORNITHINE SYNTHASE PYLB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"GLY A 497;GLY A 458;LEU A 469;MET A 468;VAL A 491","None","1.21A","3t7vA-2b3oA:undetectable","3t7vA-2b3oA:22.53"],["4CX7_D_H4BD600_1","NITRIC OXIDE SYNTHASE, INDUCIBLE;NITRIC OXIDE SYNTHASE, INDUCIBLE","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"PHE A  60;GLU A  67;ARG A 358;ILE A 279","None","1.45A","4cx7C-2b3oA:0.5;4cx7D-2b3oA:undetectable","4cx7C-2b3oA:21.92;4cx7D-2b3oA:21.92"],["4LTW_A_486A302_1","ANCESTRAL STEROID RECEPTOR 2","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"VAL A 465;LEU A 251;ILE A 508;ILE A 512;ALA A 221","None","1.03A","4ltwA-2b3oA:undetectable","4ltwA-2b3oA:19.70"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"THR A 177;GLY A 173;GLY A 174;ASP A 185","None","0.72A","4qvvK-2b3oA:undetectable;4qvvL-2b3oA:undetectable","4qvvK-2b3oA:16.89;4qvvL-2b3oA:16.92"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"THR A 177;GLY A 173;GLY A 174;ASP A 185","None","0.72A","4qvvY-2b3oA:undetectable;4qvvZ-2b3oA:undetectable","4qvvY-2b3oA:16.89;4qvvZ-2b3oA:16.92"],["4UIN_H_QI9H1226_0","FAB 314.3","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"HIS A 193;THR A 197;GLU A 182;PHE A 184;GLY A 179","None","1.14A","4uinH-2b3oA:undetectable;4uinL-2b3oA:undetectable","4uinH-2b3oA:19.14;4uinL-2b3oA:17.43"],["5DSG_A_0HKA1201_2","MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYSIN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"ASN A 101;LEU A  18;PHE A   5","None","0.77A","5dsgA-2b3oA:undetectable","5dsgA-2b3oA:20.80"],["5EEU_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5eeuD-2b3oA:undetectable;5eeuE-2b3oA:undetectable","5eeuD-2b3oA:10.15;5eeuE-2b3oA:10.15"],["5EEV_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5eevD-2b3oA:undetectable;5eevE-2b3oA:undetectable","5eevD-2b3oA:10.15;5eevE-2b3oA:10.15"],["5EEW_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5eewD-2b3oA:undetectable;5eewE-2b3oA:undetectable","5eewD-2b3oA:10.15;5eewE-2b3oA:10.15"],["5EEX_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5eexD-2b3oA:undetectable;5eexE-2b3oA:undetectable","5eexD-2b3oA:10.15;5eexE-2b3oA:10.15"],["5EEY_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5eeyD-2b3oA:undetectable;5eeyE-2b3oA:undetectable","5eeyD-2b3oA:10.15;5eeyE-2b3oA:10.15"],["5EEZ_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5eezD-2b3oA:undetectable;5eezE-2b3oA:undetectable","5eezD-2b3oA:10.15;5eezE-2b3oA:10.15"],["5EF0_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5ef0D-2b3oA:undetectable;5ef0E-2b3oA:undetectable","5ef0D-2b3oA:10.15;5ef0E-2b3oA:10.15"],["5EF1_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5ef1D-2b3oA:undetectable;5ef1E-2b3oA:undetectable","5ef1D-2b3oA:10.15;5ef1E-2b3oA:10.15"],["5EF2_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5ef2D-2b3oA:undetectable;5ef2E-2b3oA:undetectable","5ef2D-2b3oA:10.15;5ef2E-2b3oA:10.15"],["5EF3_D_TRPD101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"ARG A 358;THR A 351;GLY A 458;ALA A 455;ILE A 457","None","1.37A","5ef3D-2b3oA:undetectable;5ef3E-2b3oA:undetectable","5ef3D-2b3oA:10.15;5ef3E-2b3oA:10.15"],["5KOX_A_RFPA502_2","PENTACHLOROPHENOL 4-MONOOXYGENASE","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"VAL A  49;ARG A   7;PRO A  31","None","0.63A","5koxA-2b3oA:undetectable","5koxA-2b3oA:23.38"],["5MZR_E_PFLE409_1","PROTON-GATED ION CHANNEL","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"TYR A 509;TYR A 505;ILE A 488;ILE A 466","None","0.87A","5mzrE-2b3oA:undetectable","5mzrE-2b3oA:10.61"],["5NWW_A_ACAA18_1","SCRFP-TAG,GP41","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",5,"GLY A 497;SER A 496;ASN A 278;GLU A  74;LEU A 259","None","1.14A","5nwwA-2b3oA:undetectable","5nwwA-2b3oA:6.38"],["5TJY_A_BEZA304_0","4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"MET A 115;GLU A 121;ARG A 136","None","1.12A","5tjyA-2b3oA:undetectable","5tjyA-2b3oA:19.48"],["5TJZ_A_BEZA302_0","4-HYDROXY-TETRAHYDRODIPICOLINATE REDUCTASE","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",3,"MET A 115;GLU A 121;ARG A 136","None","1.08A","5tjzA-2b3oA:undetectable","5tjzA-2b3oA:19.48"],["6AK3_B_P2EB1201_1","PROSTAGLANDIN E2 RECEPTOR EP3 SUBTYPE,SOLUBLE CYTOCHROME B562","2b3o","TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 6","Homo sapiens",4,"PRO A 426;VAL A 510;GLY A 458;VAL A 422","None","0.94A","6ak3B-2b3oA:undetectable","6ak3B-2b3oA:8.65"]]