SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 12 ALA A 110
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
 1.24A 1ddrB-2b3qA:
undetectable		 1ddrB-2b3qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_A_AZMA400_1
(CARBONIC ANHYDRASE
XIV)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 HIS A 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CRO  A  66 ( 4.1A)
CRO  A  66 ( 4.5A)
None
 1.42A 1rj6A-2b3qA:
undetectable		 1rj6A-2b3qA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 HIS A 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CRO  A  66 ( 4.1A)
CRO  A  66 ( 4.5A)
None
 1.38A 1rj6B-2b3qA:
undetectable		 1rj6B-2b3qA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.4A)
None
None
 1.16A 3t3rB-2b3qA:
undetectable		 3t3rB-2b3qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.4A)
None
None
 1.20A 3t3rC-2b3qA:
undetectable		 3t3rC-2b3qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.4A)
None
None
 1.15A 3t3rD-2b3qA:
undetectable		 3t3rD-2b3qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		3 / 3 LYS A 140
ASN A 135
SER A 175
 None
MG  A 701 (-3.4A)
MG  A 701 ( 4.7A)
 1.26A 5yw0A-2b3qA:
undetectable		 5yw0A-2b3qA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.48A 6dlzB-2b3qA:
undetectable
6dlzC-2b3qA:
undetectable		 6dlzB-2b3qA:
14.81
6dlzC-2b3qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.47A 6dm1B-2b3qA:
undetectable
6dm1C-2b3qA:
undetectable		 6dm1B-2b3qA:
14.81
6dm1C-2b3qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 SER A  86
LEU A 201
SER A  72
ILE A 152
PRO A 196
 None
 1.47A 6dm2B-2b3qA:
undetectable
6dm2C-2b3qA:
undetectable		 6dm2B-2b3qA:
14.81
6dm2C-2b3qA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2b3q GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria) 		5 / 10 ILE A 152
PRO A 196
SER A  86
LEU A 201
SER A  72
 None
 1.48A 6dm2A-2b3qA:
undetectable
6dm2D-2b3qA:
undetectable		 6dm2A-2b3qA:
14.81
6dm2D-2b3qA:
14.81