SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b3x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A 804
LEU A 808
ALA A 784
PHE A 788
GLY A 786
 None
 1.18A 1cmaA-2b3xA:
undetectable
1cmaB-2b3xA:
undetectable		 1cmaA-2b3xA:
7.51
1cmaB-2b3xA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 784
PHE A 788
GLY A 786
LEU A 808
PRO A 815
 None
 1.14A 1cmcA-2b3xA:
undetectable
1cmcB-2b3xA:
undetectable		 1cmcA-2b3xA:
7.51
1cmcB-2b3xA:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.03A 1d4sA-2b3xA:
undetectable		 1d4sA-2b3xA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.03A 1ddsB-2b3xA:
undetectable		 1ddsB-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.18A 1dhfB-2b3xA:
undetectable		 1dhfB-2b3xA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.06A 1dhiB-2b3xA:
undetectable		 1dhiB-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.08A 1draB-2b3xA:
undetectable		 1draB-2b3xA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.05A 1dyiB-2b3xA:
undetectable		 1dyiB-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLU A 573
THR A 565
ALA A 563
LEU A 461
 None
 1.17A 1etb2-2b3xA:
undetectable		 1etb2-2b3xA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A  86
GLY A 175
CYH A 503
GLY A 474
 None
None
SF4  A1000 (-2.2A)
None
 0.69A 1f5lA-2b3xA:
undetectable		 1f5lA-2b3xA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A  27
ASN A  25
VAL A 340
GLY A 341
LEU A   8
 None
 1.43A 1fkpA-2b3xA:
undetectable		 1fkpA-2b3xA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 534
THR A 295
THR A 438
SER A 257
 None
 0.91A 1gtfL-2b3xA:
undetectable
1gtfM-2b3xA:
undetectable		 1gtfL-2b3xA:
6.19
1gtfM-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 257
GLY A 534
THR A 295
THR A 438
 None
 0.93A 1gtnD-2b3xA:
undetectable
1gtnE-2b3xA:
undetectable		 1gtnD-2b3xA:
6.19
1gtnE-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 190
ARG A  48
PRO A 198
SER A 200
 None
 1.21A 1gyxA-2b3xA:
0.0
1gyxB-2b3xA:
0.0		 1gyxA-2b3xA:
9.25
1gyxB-2b3xA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 0.99A 1hsgA-2b3xA:
undetectable		 1hsgA-2b3xA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 8 ALA A  46
ILE A 235
PRO A 240
ILE A  39
ILE A  63
 None
 1.26A 1hshD-2b3xA:
undetectable		 1hshD-2b3xA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 11 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 0.95A 1hxwB-2b3xA:
undetectable		 1hxwB-2b3xA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 0.99A 1k6cA-2b3xA:
undetectable		 1k6cA-2b3xA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 784
PHE A 788
GLY A 786
LEU A 808
PRO A 815
 None
 1.21A 1mj2A-2b3xA:
undetectable
1mj2B-2b3xA:
undetectable		 1mj2A-2b3xA:
7.63
1mj2B-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 784
PHE A 788
GLY A 786
LEU A 808
PRO A 815
 None
 1.18A 1mj2C-2b3xA:
undetectable
1mj2D-2b3xA:
undetectable		 1mj2C-2b3xA:
7.63
1mj2D-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 784
PHE A 788
GLY A 786
LEU A 808
PRO A 815
 None
 1.19A 1mjoC-2b3xA:
undetectable
1mjoD-2b3xA:
undetectable		 1mjoC-2b3xA:
7.63
1mjoD-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 784
PHE A 788
HIS A 804
LEU A 808
PRO A 815
 None
 1.10A 1mjoC-2b3xA:
undetectable
1mjoD-2b3xA:
undetectable		 1mjoC-2b3xA:
7.63
1mjoD-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 HIS A 804
LEU A 808
PRO A 815
ALA A 784
PHE A 788
 None
 1.14A 1mjqA-2b3xA:
undetectable
1mjqB-2b3xA:
undetectable		 1mjqA-2b3xA:
7.63
1mjqB-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 808
PRO A 815
ALA A 784
PHE A 788
GLY A 786
 None
 1.18A 1mjqA-2b3xA:
undetectable
1mjqB-2b3xA:
undetectable		 1mjqA-2b3xA:
7.63
1mjqB-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 10 HIS A 804
LEU A 808
PRO A 815
ALA A 784
PHE A 788
GLY A 786
 None
 1.19A 1mjqC-2b3xA:
undetectable
1mjqD-2b3xA:
undetectable		 1mjqC-2b3xA:
7.63
1mjqD-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 784
PHE A 788
HIS A 804
LEU A 808
PRO A 815
 None
 1.11A 1mjqC-2b3xA:
undetectable
1mjqD-2b3xA:
undetectable		 1mjqC-2b3xA:
7.63
1mjqD-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 HIS A 804
LEU A 808
PRO A 815
ALA A 784
PHE A 788
 None
 1.14A 1mjqG-2b3xA:
undetectable
1mjqH-2b3xA:
undetectable		 1mjqG-2b3xA:
7.63
1mjqH-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 808
PRO A 815
ALA A 784
PHE A 788
GLY A 786
 None
 1.19A 1mjqG-2b3xA:
undetectable
1mjqH-2b3xA:
undetectable		 1mjqG-2b3xA:
7.63
1mjqH-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 11 HIS A 804
LEU A 808
PRO A 815
ALA A 784
PHE A 788
GLY A 786
 None
 1.20A 1mjqI-2b3xA:
undetectable
1mjqJ-2b3xA:
undetectable		 1mjqI-2b3xA:
7.63
1mjqJ-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 784
PHE A 788
HIS A 804
LEU A 808
PRO A 815
 None
 1.12A 1mjqI-2b3xA:
undetectable
1mjqJ-2b3xA:
undetectable		 1mjqI-2b3xA:
7.63
1mjqJ-2b3xA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ALA A 453
GLY A 448
ALA A 449
LEU A 471
LEU A 491
 None
 1.16A 1nr6A-2b3xA:
undetectable		 1nr6A-2b3xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ALA A 783
TYR A 774
ILE A 792
PRO A 787
 None
 1.19A 1oniB-2b3xA:
undetectable
1oniC-2b3xA:
undetectable		 1oniB-2b3xA:
10.84
1oniC-2b3xA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ALA A 784
TYR A 774
ILE A 792
PRO A 787
 None
 1.20A 1oniB-2b3xA:
undetectable
1oniC-2b3xA:
undetectable		 1oniB-2b3xA:
10.84
1oniC-2b3xA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ALA A 783
TYR A 774
ILE A 792
PRO A 787
 None
 1.13A 1oniH-2b3xA:
undetectable
1oniI-2b3xA:
undetectable		 1oniH-2b3xA:
10.84
1oniI-2b3xA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.09A 1rx8A-2b3xA:
undetectable		 1rx8A-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 672
ALA A 770
VAL A 795
GLY A 775
VAL A 768
 None
 0.88A 1t7jA-2b3xA:
undetectable		 1t7jA-2b3xA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 560
THR A 256
THR A 258
VAL A 531
 None
 1.19A 1tv8A-2b3xA:
undetectable		 1tv8A-2b3xA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 196
PRO A 198
VAL A 312
ILE A 333
LEU A 214
 None
 1.25A 1z9hA-2b3xA:
undetectable		 1z9hA-2b3xA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 196
PRO A 198
VAL A 312
ILE A 333
LEU A 214
 None
 1.24A 1z9hB-2b3xA:
undetectable		 1z9hB-2b3xA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 196
PRO A 198
VAL A 312
ILE A 333
LEU A 214
 None
 1.25A 1z9hC-2b3xA:
undetectable		 1z9hC-2b3xA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 213
PHE A 310
PRO A 311
ASP A 313
 None
 0.85A 2aouB-2b3xA:
undetectable		 2aouB-2b3xA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 669
GLY A 672
VAL A 795
GLY A 775
PRO A 787
 None
 0.89A 2avvD-2b3xA:
undetectable		 2avvD-2b3xA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 134
VAL A 531
GLY A 427
 None
 0.65A 2avvE-2b3xA:
undetectable		 2avvE-2b3xA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 205
ASP A  87
ASN A 181
 SF4  A1000 ( 3.9A)
None
None
 0.86A 2bm9D-2b3xA:
undetectable		 2bm9D-2b3xA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 777
SER A 674
ARG A 536
GLU A 773
 None
 0.99A 2c8aB-2b3xA:
undetectable		 2c8aB-2b3xA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 777
SER A 674
ARG A 536
GLU A 773
 None
 1.09A 2c8aD-2b3xA:
undetectable		 2c8aD-2b3xA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 130
VAL A 498
THR A 438
THR A 440
LEU A 551
 None
 0.99A 2cbrA-2b3xA:
undetectable		 2cbrA-2b3xA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 808
VAL A 813
GLY A 812
GLY A 878
ALA A 784
 None
 0.67A 2egvA-2b3xA:
undetectable		 2egvA-2b3xA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 808
VAL A 813
GLY A 812
GLY A 878
ALA A 784
 None
 0.64A 2egvB-2b3xA:
undetectable		 2egvB-2b3xA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.17A 2f8gB-2b3xA:
undetectable		 2f8gB-2b3xA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 560
THR A 256
THR A 258
VAL A 531
 None
 1.18A 2fb2A-2b3xA:
2.1		 2fb2A-2b3xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 560
THR A 256
THR A 258
VAL A 531
 None
 1.20A 2fb2B-2b3xA:
undetectable		 2fb2B-2b3xA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 220
SER A 779
ASP A 125
THR A 208
HIS A 178
 None
None
None
None
SF4  A1000 (-4.5A)
 1.48A 2hmaA-2b3xA:
undetectable		 2hmaA-2b3xA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  90
ALA A  93
ASP A  96
ILE A 224
GLY A 222
 None
 1.00A 2hs1A-2b3xA:
undetectable		 2hs1A-2b3xA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.13A 2ienA-2b3xA:
undetectable		 2ienA-2b3xA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 478
THR A 479
VAL A 498
GLY A 500
 None
 1.14A 2p2fA-2b3xA:
2.6		 2p2fA-2b3xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.03A 2q63A-2b3xA:
undetectable		 2q63A-2b3xA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.02A 2qakA-2b3xA:
undetectable		 2qakA-2b3xA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 536
GLN A 377
PRO A 376
 None
 0.71A 2qhfA-2b3xA:
undetectable		 2qhfA-2b3xA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A  32
LEU A  43
ILE A  60
VAL A 340
HIS A   7
 None
 1.35A 2qo4A-2b3xA:
undetectable		 2qo4A-2b3xA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.23A 2w3aB-2b3xA:
undetectable		 2w3aB-2b3xA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 211
GLY A 218
GLY A 203
ARG A 187
ILE A  84
 None
 1.28A 2y7kC-2b3xA:
undetectable		 2y7kC-2b3xA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A 211
GLY A 218
GLY A 203
HIS A 178
ILE A  84
 None
None
None
SF4  A1000 (-4.5A)
None
 1.34A 2y7pA-2b3xA:
undetectable		 2y7pA-2b3xA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 811
VAL A 809
GLU A 225
GLY A 222
GLN A  86
 None
 1.39A 3bwyA-2b3xA:
undetectable		 3bwyA-2b3xA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A 222
GLU A 225
GLY A 220
ASN A 807
 None
 1.09A 3e9rA-2b3xA:
undetectable		 3e9rA-2b3xA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A 222
GLU A 225
GLY A 220
ASN A 807
 None
 1.11A 3e9rC-2b3xA:
undetectable		 3e9rC-2b3xA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 8 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.96A 3ekpA-2b3xA:
undetectable		 3ekpA-2b3xA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.96A 3ektA-2b3xA:
undetectable		 3ektA-2b3xA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 11 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.15A 3ektC-2b3xA:
undetectable		 3ektC-2b3xA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 0.96A 3ekxA-2b3xA:
undetectable		 3ekxA-2b3xA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 798
ALA A 770
GLY A 672
LEU A 669
SER A 799
 None
 1.05A 3g2oB-2b3xA:
undetectable		 3g2oB-2b3xA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 798
ALA A 770
GLY A 672
LEU A 769
SER A 799
 None
 1.08A 3g2oB-2b3xA:
undetectable		 3g2oB-2b3xA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 175
GLN A 179
VAL A 180
MET A 488
ILE A 616
 None
 1.28A 3h52B-2b3xA:
undetectable		 3h52B-2b3xA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A 778
ASP A 678
ASP A 781
 None
 0.95A 3iv6C-2b3xA:
undetectable		 3iv6C-2b3xA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.04A 3k4vB-2b3xA:
undetectable		 3k4vB-2b3xA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 553
LEU A 494
ALA A 559
LEU A 586
 None
 0.90A 3kk6B-2b3xA:
undetectable		 3kk6B-2b3xA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A  27
ASN A  25
VAL A 340
GLY A 341
LEU A   8
 None
 1.46A 3lp1A-2b3xA:
undetectable		 3lp1A-2b3xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.16A 3lzuB-2b3xA:
undetectable		 3lzuB-2b3xA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 310
ILE A 296
ALA A 297
ALA A 305
 None
 0.91A 3mdrB-2b3xA:
undetectable		 3mdrB-2b3xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.14A 3n0hA-2b3xA:
undetectable		 3n0hA-2b3xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  90
ALA A  93
ASP A  96
ILE A 224
GLY A 222
 None
 1.06A 3ndxA-2b3xA:
undetectable		 3ndxA-2b3xA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 223
ILE A  84
VAL A  83
 None
 0.47A 3nv6A-2b3xA:
undetectable		 3nv6A-2b3xA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.97A 3oxvC-2b3xA:
undetectable		 3oxvC-2b3xA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.98A 3oxwA-2b3xA:
undetectable		 3oxwA-2b3xA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A  90
ALA A  93
ASP A  96
ILE A 224
GLY A 222
 None
 1.02A 3oxwC-2b3xA:
undetectable		 3oxwC-2b3xA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.96A 3oy4B-2b3xA:
undetectable		 3oy4B-2b3xA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 682
ILE A 686
LEU A 696
ASN A 715
 None
 0.97A 3p50A-2b3xA:
0.0		 3p50A-2b3xA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 682
ILE A 686
LEU A 696
ASN A 715
 None
 0.97A 3p50B-2b3xA:
0.0		 3p50B-2b3xA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 682
ILE A 686
LEU A 696
ASN A 715
 None
 0.98A 3p50C-2b3xA:
0.0		 3p50C-2b3xA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 682
ILE A 686
LEU A 696
ASN A 715
 None
 0.97A 3p50D-2b3xA:
0.0		 3p50D-2b3xA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 682
ILE A 686
LEU A 696
ASN A 715
 None
 0.97A 3p50E-2b3xA:
0.0		 3p50E-2b3xA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.04A 3ql0A-2b3xA:
undetectable		 3ql0A-2b3xA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 225
ILE A 235
SER A 236
GLU A  75
THR A 867
 None
 1.37A 3r75A-2b3xA:
undetectable		 3r75A-2b3xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 225
ILE A 235
SER A 236
GLU A  75
THR A 867
 None
 1.37A 3r75B-2b3xA:
undetectable		 3r75B-2b3xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLU A 225
ILE A 235
SER A 236
GLU A  75
THR A 867
 None
 1.37A 3r76A-2b3xA:
undetectable		 3r76A-2b3xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REQ_A_ADNA801_1
(METHYLMALONYL-COA
MUTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 TYR A 818
TYR A 835
GLU A 833
GLY A 831
 None
 1.31A 3reqA-2b3xA:
3.0		 3reqA-2b3xA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.14A 3s3vA-2b3xA:
undetectable		 3s3vA-2b3xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 770
VAL A 795
GLY A 775
PRO A 787
VAL A 768
 None
 0.92A 3so9B-2b3xA:
undetectable		 3so9B-2b3xA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 828
TYR A 818
GLU A 822
LEU A 819
VAL A 851
 None
 1.23A 3t7vA-2b3xA:
2.2		 3t7vA-2b3xA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.15A 3tkwB-2b3xA:
undetectable		 3tkwB-2b3xA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		6 / 12 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
PRO A 787
 None
 1.08A 3tl9B-2b3xA:
undetectable		 3tl9B-2b3xA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 SER A 640
VAL A  91
ILE A 643
THR A 628
 None
 1.05A 3tneB-2b3xA:
undetectable		 3tneB-2b3xA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 312
SER A 316
GLY A 213
ARG A 293
 None
 1.40A 3v4tA-2b3xA:
undetectable
3v4tD-2b3xA:
undetectable		 3v4tA-2b3xA:
20.55
3v4tD-2b3xA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ALA A 687
ILE A 686
ARG A 694
GLY A 722
 None
 0.85A 3v4tH-2b3xA:
undetectable		 3v4tH-2b3xA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PRO A 171
GLN A 179
ILE A 616
TYR A 613
PHE A 609
 None
 0.93A 4a79A-2b3xA:
undetectable		 4a79A-2b3xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PRO A 171
GLN A 179
ILE A 616
TYR A 613
PHE A 609
 None
 0.94A 4a79B-2b3xA:
undetectable		 4a79B-2b3xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 PRO A 171
GLN A 179
ILE A 616
TYR A 613
PHE A 609
 None
 0.99A 4a7aB-2b3xA:
undetectable		 4a7aB-2b3xA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.08A 4dfrB-2b3xA:
undetectable		 4dfrB-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.99A 4dqcB-2b3xA:
undetectable		 4dqcB-2b3xA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.99A 4dqeB-2b3xA:
undetectable		 4dqeB-2b3xA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 199
ARG A 187
ASP A 212
 None
 0.88A 4fp9C-2b3xA:
undetectable		 4fp9C-2b3xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 199
ARG A 187
ASP A 212
 None
 0.85A 4fp9F-2b3xA:
undetectable		 4fp9F-2b3xA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 149
GLU A 146
PHE A 154
 None
 0.92A 4kszA-2b3xA:
0.3		 4kszA-2b3xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 740
THR A 741
LEU A 669
THR A 677
 None
 0.85A 4mbsA-2b3xA:
undetectable		 4mbsA-2b3xA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 669
GLY A 672
ALA A 770
VAL A 795
GLY A 775
 None
 0.96A 4njtB-2b3xA:
undetectable		 4njtB-2b3xA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 491
LEU A 494
GLY A 495
VAL A 557
VAL A 130
 None
 0.98A 4ok1A-2b3xA:
undetectable		 4ok1A-2b3xA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.07A 4pthA-2b3xA:
undetectable		 4pthA-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.10A 4qlgB-2b3xA:
undetectable		 4qlgB-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 154
TYR A 642
ASN A 707
ILE A 507
 None
None
None
SF4  A1000 ( 3.8A)
 0.81A 4qoiA-2b3xA:
undetectable
4qoiB-2b3xA:
undetectable		 4qoiA-2b3xA:
13.96
4qoiB-2b3xA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.11A 4rgcA-2b3xA:
undetectable		 4rgcA-2b3xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 177
VAL A 123
PHE A 147
HIS A 207
 None
None
None
SF4  A1000 (-4.1A)
 1.15A 4rzvA-2b3xA:
undetectable		 4rzvA-2b3xA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 393
LEU A 526
VAL A 527
ARG A 567
 None
 0.96A 4uswA-2b3xA:
undetectable		 4uswA-2b3xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 827
LEU A 829
GLU A 817
ALA A 797
LEU A 796
 None
 1.02A 4wg0B-2b3xA:
undetectable
4wg0C-2b3xA:
undetectable
4wg0D-2b3xA:
undetectable		 4wg0B-2b3xA:
1.66
4wg0C-2b3xA:
1.66
4wg0D-2b3xA:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 827
LEU A 829
GLU A 817
ALA A 797
LEU A 796
 None
 1.02A 4wg0D-2b3xA:
undetectable
4wg0E-2b3xA:
undetectable
4wg0F-2b3xA:
undetectable		 4wg0D-2b3xA:
1.66
4wg0E-2b3xA:
1.66
4wg0F-2b3xA:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 827
LEU A 829
GLU A 817
ALA A 797
LEU A 796
 None
 1.02A 4wg0F-2b3xA:
undetectable
4wg0G-2b3xA:
undetectable
4wg0H-2b3xA:
undetectable		 4wg0F-2b3xA:
1.66
4wg0G-2b3xA:
1.66
4wg0H-2b3xA:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLU A 817
ALA A 797
LEU A 796
LEU A 827
LEU A 829
 None
 1.09A 4wg0G-2b3xA:
undetectable
4wg0H-2b3xA:
undetectable
4wg0I-2b3xA:
undetectable		 4wg0G-2b3xA:
1.66
4wg0H-2b3xA:
1.66
4wg0I-2b3xA:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.13A 4x5fA-2b3xA:
undetectable		 4x5fA-2b3xA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 558
ALA A 432
ILE A 568
LEU A 575
THR A 469
 None
 1.13A 4x5fB-2b3xA:
undetectable		 4x5fB-2b3xA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 671
ASP A 673
ILE A 767
 None
 0.69A 4xi3D-2b3xA:
undetectable		 4xi3D-2b3xA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 779
HIS A 178
HIS A 207
THR A 208
 None
SF4  A1000 (-4.5A)
SF4  A1000 (-4.1A)
None
 0.93A 5eevL-2b3xA:
undetectable
5eevV-2b3xA:
undetectable		 5eevL-2b3xA:
6.19
5eevV-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 779
HIS A 178
HIS A 207
THR A 208
 None
SF4  A1000 (-4.5A)
SF4  A1000 (-4.1A)
None
 0.93A 5eewL-2b3xA:
undetectable
5eewV-2b3xA:
undetectable		 5eewL-2b3xA:
6.19
5eewV-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 779
HIS A 178
HIS A 207
THR A 208
 None
SF4  A1000 (-4.5A)
SF4  A1000 (-4.1A)
None
 0.94A 5ef3L-2b3xA:
undetectable
5ef3V-2b3xA:
undetectable		 5ef3L-2b3xA:
6.19
5ef3V-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A 185
TYR A 501
PRO A 171
ILE A 169
 None
 1.15A 5esgA-2b3xA:
undetectable		 5esgA-2b3xA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 794
ILE A 686
GLY A 710
HIS A 804
PHE A 724
 None
 1.17A 5fsaA-2b3xA:
undetectable		 5fsaA-2b3xA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 794
ILE A 686
GLY A 710
HIS A 804
PHE A 724
 None
 1.01A 5jlcA-2b3xA:
undetectable		 5jlcA-2b3xA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 PRO A 514
TYR A 417
SER A 138
ASN A 133
 EDO  A1002 ( 4.7A)
None
None
EDO  A1002 (-3.1A)
 1.11A 5l1fC-2b3xA:
undetectable		 5l1fC-2b3xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 811
VAL A 809
GLU A 225
GLY A 222
GLN A  86
 None
 1.40A 5lsaA-2b3xA:
undetectable		 5lsaA-2b3xA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 THR A 677
ARG A 780
ASP A 781
GLY A 222
 None
 1.18A 5mraA-2b3xA:
undetectable
5mraB-2b3xA:
undetectable		 5mraA-2b3xA:
11.29
5mraB-2b3xA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 1.01A 5n0oA-2b3xA:
undetectable		 5n0oA-2b3xA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 1.01A 5n0rA-2b3xA:
undetectable		 5n0rA-2b3xA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 0.97A 5n0sA-2b3xA:
undetectable		 5n0sA-2b3xA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 0.99A 5n0wA-2b3xA:
undetectable		 5n0wA-2b3xA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 0.98A 5n0wB-2b3xA:
undetectable		 5n0wB-2b3xA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 566
GLY A 427
HIS A 426
VAL A 527
VAL A 531
 None
 0.97A 5n4iA-2b3xA:
undetectable		 5n4iA-2b3xA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 771
ASN A 823
GLU A 822
GLU A 798
GLU A 817
 None
 1.32A 5nwvA-2b3xA:
undetectable		 5nwvA-2b3xA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 431
PHE A 415
ALA A 425
LEU A 424
ALA A 520
 None
 1.27A 5oy02-2b3xA:
undetectable		 5oy02-2b3xA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 718
ARG A 721
LEU A 701
ILE A 686
 None
 1.01A 5v0vA-2b3xA:
undetectable		 5v0vA-2b3xA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 477
PRO A 473
GLY A 474
TYR A 501
 None
 1.32A 5x80A-2b3xA:
undetectable
5x80B-2b3xA:
undetectable		 5x80A-2b3xA:
11.43
5x80B-2b3xA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 473
GLY A 474
TYR A 501
VAL A 477
 None
 1.36A 5x80C-2b3xA:
undetectable
5x80D-2b3xA:
undetectable		 5x80C-2b3xA:
11.43
5x80D-2b3xA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 VAL A 612
TYR A 480
GLU A 183
 None
 0.97A 5zmqD-2b3xA:
undetectable
5zmqE-2b3xA:
undetectable		 5zmqD-2b3xA:
12.88
5zmqE-2b3xA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 491
GLY A 500
PRO A 443
GLN A 483
MET A 488
 None
 1.50A 6euqA-2b3xA:
0.0		 6euqA-2b3xA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 THR A 435
CYH A 437
THR A 438
GLY A 534
 None
SF4  A1000 (-2.3A)
None
None
 0.90A 6gtqA-2b3xA:
undetectable		 6gtqA-2b3xA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 707
ASN A 509
ILE A 128
ILE A 507
PHE A 154
 None
None
None
SF4  A1000 ( 3.8A)
None
 1.25A 6j21A-2b3xA:
undetectable		 6j21A-2b3xA:
19.30