SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b49'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		3 / 3 ASN A 674
ASN A 697
ARG A 881
 None
 0.67A 2rlcA-2b49A:
undetectable		 2rlcA-2b49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		3 / 3 ARG A 829
ASP A 834
ASN A 712
 None
 0.82A 2zzmA-2b49A:
undetectable		 2zzmA-2b49A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		3 / 3 LEU A 866
PRO A 867
LEU A 861
 None
 0.52A 3hcrA-2b49A:
undetectable		 3hcrA-2b49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		4 / 7 GLU A 777
HIS A 803
GLN A 805
VAL A 807
 None
 1.03A 3kp6B-2b49A:
undetectable		 3kp6B-2b49A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		5 / 12 ASP A 760
THR A 747
LEU A 746
THR A 745
GLN A 805
 None
 1.32A 4ng6A-2b49A:
undetectable		 4ng6A-2b49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		4 / 5 GLN A 735
ILE A 715
ILE A 696
TYR A 700
 None
 1.11A 5dnuA-2b49A:
undetectable		 5dnuA-2b49A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		4 / 5 ARG A 881
CYH A 842
GLN A 718
ILE A 846
 None
 1.49A 5ki6A-2b49A:
0.0		 5ki6A-2b49A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		5 / 6 ILE A 873
ALA A 858
LEU A 861
ILE A 705
TYR A 714
 None
 1.23A 5mvmB-2b49A:
undetectable
5mvmC-2b49A:
undetectable		 5mvmB-2b49A:
14.03
5mvmC-2b49A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		5 / 12 VAL A 840
THR A 849
LEU A 831
PHE A 824
PHE A 821
 None
 1.36A 6a93B-2b49A:
undetectable		 6a93B-2b49A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens) 		3 / 3 ILE A 662
THR A 663
PRO A 681
 None
 0.54A 6ncsA-2b49A:
undetectable		 6ncsA-2b49A:
22.52