SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 2b4a BH3024
(Bacillus
halodurans) 		4 / 6 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 0.99A 1errB-2b4aA:
undetectable		 1errB-2b4aA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2b4a BH3024
(Bacillus
halodurans) 		5 / 12 LEU A  52
LEU A  51
ILE A  63
ILE A  19
LEU A   8
 None
 1.18A 1tw4B-2b4aA:
undetectable		 1tw4B-2b4aA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 2b4a BH3024
(Bacillus
halodurans) 		4 / 5 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 1.02A 2jfaA-2b4aA:
undetectable		 2jfaA-2b4aA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2b4a BH3024
(Bacillus
halodurans) 		3 / 3 HIS A  22
ILE A 113
LEU A 100
 None
 0.68A 2kceA-2b4aA:
undetectable		 2kceA-2b4aA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 2b4a BH3024
(Bacillus
halodurans) 		4 / 5 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 1.01A 2qxsA-2b4aA:
undetectable		 2qxsA-2b4aA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 2b4a BH3024
(Bacillus
halodurans) 		4 / 5 LEU A 100
ASP A  56
LEU A  23
HIS A 116
 None
 1.03A 2qxsB-2b4aA:
undetectable		 2qxsB-2b4aA:
18.05