SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 4 HIS A 225
ASP A 289
SER A 315
ASP A  36
 None
 1.33A 1n2xA-2b4eA:
0.0		 1n2xA-2b4eA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2b4e CORONIN-1A
(Mus
musculus) 		3 / 3 LEU A  60
MET A  47
MET A 107
 None
 0.90A 2vavF-2b4eA:
undetectable		 2vavF-2b4eA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2b4e CORONIN-1A
(Mus
musculus) 		3 / 3 SER A 356
ARG A 354
GLN A 360
 None
 0.87A 2xnrA-2b4eA:
undetectable		 2xnrA-2b4eA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 10 VAL A  70
LEU A  62
MET A  47
ARG A  29
LEU A 340
 None
 1.31A 3qeoA-2b4eA:
0.0		 3qeoA-2b4eA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 LEU A 307
THR A 298
ILE A 297
GLN A 262
LEU A 249
 None
 1.26A 4o5fA-2b4eA:
undetectable
4o5fB-2b4eA:
undetectable		 4o5fA-2b4eA:
22.38
4o5fB-2b4eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 GLN A 262
LEU A 249
LEU A 307
THR A 298
ILE A 297
 None
 1.29A 4o5fA-2b4eA:
undetectable
4o5fB-2b4eA:
undetectable		 4o5fA-2b4eA:
22.38
4o5fB-2b4eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 5 ARG A 196
ARG A 216
GLY A 220
GLU A 219
 None
 0.99A 4z3oA-2b4eA:
undetectable
4z3oB-2b4eA:
undetectable		 4z3oA-2b4eA:
19.42
4z3oB-2b4eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 5 GLU A 296
THR A 279
HIS A 225
LEU A 284
 None
 1.16A 5axaA-2b4eA:
undetectable		 5axaA-2b4eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 5 GLU A 296
THR A 279
HIS A 225
LEU A 284
 None
 1.15A 5axaC-2b4eA:
undetectable		 5axaC-2b4eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 LEU A 307
THR A 298
ILE A 297
GLN A 262
LEU A 249
 None
 1.24A 5b8hA-2b4eA:
undetectable
5b8hB-2b4eA:
undetectable		 5b8hA-2b4eA:
21.71
5b8hB-2b4eA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 6 ARG A 216
GLY A 220
GLU A 219
ARG A 196
 None
 1.06A 5btaA-2b4eA:
undetectable
5btaB-2b4eA:
undetectable
5btaC-2b4eA:
undetectable		 5btaA-2b4eA:
22.61
5btaB-2b4eA:
21.45
5btaC-2b4eA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 6 ARG A 196
ARG A 216
GLY A 220
GLU A 219
 None
 1.09A 5btcA-2b4eA:
undetectable
5btcC-2b4eA:
undetectable
5btcD-2b4eA:
undetectable		 5btcA-2b4eA:
22.61
5btcC-2b4eA:
22.61
5btcD-2b4eA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 7 ARG A 216
GLY A 220
GLU A 219
ARG A 196
 None
 0.99A 5btfA-2b4eA:
undetectable
5btfB-2b4eA:
undetectable
5btfC-2b4eA:
undetectable		 5btfA-2b4eA:
22.61
5btfB-2b4eA:
21.45
5btfC-2b4eA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 7 ARG A 196
ARG A 216
GLY A 220
GLU A 219
 None
 0.94A 5btfA-2b4eA:
undetectable
5btfC-2b4eA:
undetectable
5btfD-2b4eA:
undetectable		 5btfA-2b4eA:
22.61
5btfC-2b4eA:
22.61
5btfD-2b4eA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 6 SER A  31
GLU A  52
GLY A 286
GLY A 288
 None
 0.84A 5cdpA-2b4eA:
undetectable
5cdpB-2b4eA:
undetectable		 5cdpA-2b4eA:
24.10
5cdpB-2b4eA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 6 ARG A 196
ARG A 216
GLY A 220
GLU A 219
 None
 1.07A 5cdqA-2b4eA:
undetectable
5cdqC-2b4eA:
undetectable
5cdqD-2b4eA:
undetectable		 5cdqA-2b4eA:
24.10
5cdqC-2b4eA:
24.10
5cdqD-2b4eA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 6 ASP A 278
ILE A 390
ARG A 325
TYR A 321
 None
 1.47A 5igyA-2b4eA:
3.8		 5igyA-2b4eA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 GLU A 102
ARG A 133
GLY A 135
ASP A 103
GLY A  57
 None
 1.06A 5vooA-2b4eA:
undetectable		 5vooA-2b4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 GLU A 102
ARG A 133
GLY A 135
ASP A 103
GLY A  57
 None
 1.07A 5vooB-2b4eA:
undetectable		 5vooB-2b4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 GLU A 102
ARG A 133
GLY A 135
ASP A 103
PHE A  39
 None
 1.05A 5vooB-2b4eA:
undetectable		 5vooB-2b4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2b4e CORONIN-1A
(Mus
musculus) 		5 / 12 GLU A 102
ARG A 133
GLY A 135
ASP A 103
GLY A  57
 None
 1.06A 5vooC-2b4eA:
undetectable		 5vooC-2b4eA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2b4e CORONIN-1A
(Mus
musculus) 		4 / 6 GLN A 262
GLU A 263
HIS A 218
ALA A 248
 None
 1.36A 6f6jC-2b4eA:
undetectable
6f6jD-2b4eA:
undetectable		 6f6jC-2b4eA:
22.48
6f6jD-2b4eA:
22.48