SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 ALA A 179
ARG A 240
TYR A 142
PHE A 144
 None
GOL  A1401 (-3.0A)
None
None
 1.10A 2ajvH-2b4gA:
undetectable
2ajvL-2b4gA:
undetectable		 2ajvH-2b4gA:
22.44
2ajvL-2b4gA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 SER A  45
LEU A  72
GLY A  53
ILE A 212
 FMN  A1400 (-2.8A)
ORO  A1399 (-4.1A)
None
None
 1.03A 2bdmA-2b4gA:
undetectable		 2bdmA-2b4gA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 9 VAL A 134
GLY A  71
THR A  47
GLY A 101
LYS A 137
 None
ORO  A1399 (-3.7A)
None
None
None
 1.44A 3bjwG-2b4gA:
undetectable		 3bjwG-2b4gA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 HIS A 261
GLY A 222
GLY A 223
LEU A  64
ALA A 230
 None
FMN  A1400 (-3.7A)
FMN  A1400 (-3.4A)
None
None
 1.16A 3i5uA-2b4gA:
undetectable		 3i5uA-2b4gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 HIS A 261
GLY A 222
GLY A 223
LEU A  64
ALA A 230
 None
FMN  A1400 (-3.7A)
FMN  A1400 (-3.4A)
None
None
 1.16A 3i5uB-2b4gA:
2.0		 3i5uB-2b4gA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 THR A 192
GLY A 248
GLY A 272
THR A 273
 None
None
FMN  A1400 (-3.3A)
FMN  A1400 (-3.6A)
 0.85A 3tajA-2b4gA:
undetectable		 3tajA-2b4gA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 VAL A 252
ALA A 258
THR A 295
PRO A  15
LEU A   3
 None
 1.41A 5mm4B-2b4gA:
0.5		 5mm4B-2b4gA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 TYR A 253
GLU A 256
GLY A 251
GLY A 223
 None
None
FMN  A1400 (-3.9A)
FMN  A1400 (-3.4A)
 0.86A 5x7pB-2b4gA:
2.8		 5x7pB-2b4gA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 THR A 123
LEU A  97
ILE A  42
TYR A  83
 None
 0.99A 5zsfA-2b4gA:
undetectable
5zsfB-2b4gA:
undetectable		 5zsfA-2b4gA:
15.30
5zsfB-2b4gA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 LEU A 231
VAL A 252
VAL A 226
GLY A 251
LEU A 260
 None
None
None
FMN  A1400 (-3.9A)
None
 1.34A 6bsgA-2b4gA:
undetectable		 6bsgA-2b4gA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 LEU A 231
VAL A 252
VAL A 226
GLY A 250
LEU A 260
 None
None
None
FMN  A1400 (-3.3A)
None
 1.49A 6bsiA-2b4gA:
0.3		 6bsiA-2b4gA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 LEU A 231
VAL A 252
VAL A 226
GLY A 251
LEU A 260
 None
None
None
FMN  A1400 (-3.9A)
None
 1.29A 6bsiA-2b4gA:
0.3		 6bsiA-2b4gA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2b4g DIHYDROOROTATE
DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 9 ILE A 282
ALA A 274
GLY A 272
GLY A  61
TYR A  59
 None
None
FMN  A1400 (-3.3A)
None
FMN  A1400 (-4.8A)
 1.27A 6nm4B-2b4gA:
undetectable		 6nm4B-2b4gA:
20.31