SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 8 VAL A 426
TYR A 273
TYR A 319
VAL A 323
 None
 1.06A 1fduB-2b4vA:
undetectable		 1fduB-2b4vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		5 / 11 LEU A 280
ILE A 281
ASN A 277
VAL A  87
GLY A  84
 None
 1.34A 2bxeA-2b4vA:
undetectable		 2bxeA-2b4vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 6 TYR A 279
TYR A 423
TYR A 319
LEU A 390
 None
 1.04A 2w98A-2b4vA:
undetectable
2w98B-2b4vA:
undetectable		 2w98A-2b4vA:
20.21
2w98B-2b4vA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 LEU A 370
ALA A 301
GLY A 303
PHE A 374
 None
 0.97A 2wq5A-2b4vA:
undetectable		 2wq5A-2b4vA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		3 / 3 ARG A  94
GLY A  95
SER A 318
 None
 0.63A 2xctB-2b4vA:
4.0		 2xctB-2b4vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		3 / 3 PRO A 357
LEU A 358
GLN A  91
 None
 0.69A 3hznG-2b4vA:
undetectable
3hznH-2b4vA:
undetectable		 3hznG-2b4vA:
19.02
3hznH-2b4vA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		5 / 11 VAL A 323
ILE A 326
ILE A 281
SER A 278
PRO A 422
 None
 1.22A 3kpcA-2b4vA:
undetectable		 3kpcA-2b4vA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		5 / 12 VAL A 323
ILE A 326
ILE A 281
SER A 278
PRO A 422
 None
 1.16A 3kpdB-2b4vA:
undetectable		 3kpdB-2b4vA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_2
(GLUCOCORTICOID
RECEPTOR)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 6 LEU A  98
MET A  56
GLN A  64
TYR A 352
 None
 1.29A 3mnpA-2b4vA:
0.2		 3mnpA-2b4vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 5 ILE A  61
MET A 263
ASN A 154
PHE A  57
 None
 1.12A 3octA-2b4vA:
undetectable		 3octA-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 5 TYR A 423
SER A 278
ASP A 421
ILE A 419
 None
 1.28A 3uj7B-2b4vA:
undetectable		 3uj7B-2b4vA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 6 CYH A 221
THR A 222
ASN A 202
ILE A 206
 None
 1.17A 3w9tB-2b4vA:
undetectable		 3w9tB-2b4vA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.19A 4fevD-2b4vA:
undetectable		 4fevD-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.19A 4fevF-2b4vA:
undetectable		 4fevF-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.22A 4fewB-2b4vA:
undetectable		 4fewB-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 8 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.17A 4fewD-2b4vA:
undetectable		 4fewD-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 8 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.20A 4fewF-2b4vA:
undetectable		 4fewF-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.22A 4fexB-2b4vA:
undetectable		 4fexB-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 8 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.16A 4gkhB-2b4vA:
undetectable		 4gkhB-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.20A 4gkhG-2b4vA:
undetectable		 4gkhG-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 8 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.18A 4gkiA-2b4vA:
undetectable		 4gkiA-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 8 ASP A 421
ASP A  99
ASN A 277
GLU A 424
 None
 1.21A 4gkiC-2b4vA:
undetectable		 4gkiC-2b4vA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		3 / 3 LEU A  70
ARG A 127
MET A 240
 None
 0.91A 4m11C-2b4vA:
undetectable		 4m11C-2b4vA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		3 / 3 MET A  56
GLN A  64
TYR A 352
 None
 0.97A 4udcA-2b4vA:
undetectable		 4udcA-2b4vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 5 THR A 364
GLY A 367
HIS A 294
ASP A 362
 None
 1.21A 5c0oH-2b4vA:
undetectable		 5c0oH-2b4vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		3 / 3 CYH A 361
MET A  44
ASN A  47
 None
 1.23A 5qh8A-2b4vA:
undetectable		 5qh8A-2b4vA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 PHE A 325
VAL A 299
ILE A 375
THR A 295
 None
 1.00A 5vkqA-2b4vA:
undetectable
5vkqD-2b4vA:
undetectable		 5vkqA-2b4vA:
14.67
5vkqD-2b4vA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ILE A 268
LEU A 100
ILE A 228
ALA A  60
 None
 0.80A 6b5vA-2b4vA:
undetectable
6b5vC-2b4vA:
0.0		 6b5vA-2b4vA:
10.68
6b5vC-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ALA A  60
ILE A 268
LEU A 100
ILE A 228
 None
 0.83A 6b5vA-2b4vA:
undetectable
6b5vB-2b4vA:
0.8		 6b5vA-2b4vA:
10.68
6b5vB-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ILE A 268
LEU A 100
ILE A 228
ALA A  60
 None
 0.80A 6b5vC-2b4vA:
0.0
6b5vD-2b4vA:
undetectable		 6b5vC-2b4vA:
10.68
6b5vD-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		4 / 7 ALA A  60
ILE A 268
LEU A 100
ILE A 228
 None
 0.80A 6b5vB-2b4vA:
undetectable
6b5vD-2b4vA:
undetectable		 6b5vB-2b4vA:
10.68
6b5vD-2b4vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2b4v RNA EDITING COMPLEX
PROTEIN MP57
(Trypanosoma
brucei) 		3 / 3 ARG A 293
HIS A 286
ARG A 282
 None
 1.16A 6dwdD-2b4vA:
undetectable		 6dwdD-2b4vA:
22.09