SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.45A 1d4fB-2b4wA:
undetectable		 1d4fB-2b4wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.46A 1d4fD-2b4wA:
undetectable		 1d4fD-2b4wA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 11 ILE A 175
PHE A 125
LEU A 145
ILE A  94
TYR A  85
 None
 1.04A 1dg5A-2b4wA:
undetectable		 1dg5A-2b4wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.18A 1hrkA-2b4wA:
undetectable		 1hrkA-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 ALA A 266
ILE A 269
GLY A 245
ILE A 243
ILE A 206
 None
 0.85A 1hshC-2b4wA:
undetectable		 1hshC-2b4wA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 8 ALA A 266
GLY A 245
ILE A 243
PRO A 296
ILE A 206
 None
 1.21A 1hshD-2b4wA:
undetectable		 1hshD-2b4wA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 265
ILE A  45
GLY A 282
VAL A  30
PRO A  84
 None
 1.17A 1sg9A-2b4wA:
undetectable		 1sg9A-2b4wA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 265
ILE A  45
GLY A 282
VAL A  30
PRO A  84
 None
 1.15A 1sg9C-2b4wA:
undetectable		 1sg9C-2b4wA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.21A 2hrcA-2b4wA:
undetectable		 2hrcA-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.20A 2po5A-2b4wA:
undetectable		 2po5A-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.19A 2po7A-2b4wA:
undetectable		 2po7A-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.21A 2po7B-2b4wA:
undetectable		 2po7B-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		4 / 7 PRO A  36
THR A  43
LEU A  20
PHE A  71
 None
 1.02A 2vl2B-2b4wA:
undetectable		 2vl2B-2b4wA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A 231
CYH A 205
VAL A 192
GLY A 207
LEU A 181
 None
 0.99A 3ijdB-2b4wA:
undetectable		 3ijdB-2b4wA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 ALA A 178
SER A 149
ILE A 135
LEU A 170
GLY A 171
 None
 1.24A 3nrrB-2b4wA:
undetectable		 3nrrB-2b4wA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 TYR A 280
SER A  34
SER A  38
PHE A  71
GLU A 288
 None
 1.04A 4bupB-2b4wA:
0.0		 4bupB-2b4wA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		4 / 4 SER A 281
TYR A 250
GLY A 268
PRO A  36
 None
 1.08A 4e3aA-2b4wA:
undetectable		 4e3aA-2b4wA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A 164
ALA A  87
PHE A 114
MET A 132
THR A 126
 None
 1.22A 4iarA-2b4wA:
undetectable		 4iarA-2b4wA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.50A 4lvcA-2b4wA:
undetectable		 4lvcA-2b4wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.44A 4lvcC-2b4wA:
undetectable		 4lvcC-2b4wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.38A 4pfjA-2b4wA:
undetectable		 4pfjA-2b4wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.47A 5m5kA-2b4wA:
undetectable		 5m5kA-2b4wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.46A 5m5kC-2b4wA:
undetectable		 5m5kC-2b4wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.48A 5m66B-2b4wA:
undetectable		 5m66B-2b4wA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 8 ILE A 183
LEU A 184
ILE A 159
ASN A 193
SER A 281
 None
 1.44A 5numA-2b4wA:
undetectable		 5numA-2b4wA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		4 / 6 VAL A 225
ILE A 243
LYS A   2
TYR A 211
 None
 1.43A 5q1sA-2b4wA:
undetectable		 5q1sA-2b4wA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.47A 5v96A-2b4wA:
undetectable		 5v96A-2b4wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		4 / 6 GLY A 207
TYR A 227
LEU A 279
VAL A 264
 None
 0.84A 5x80A-2b4wA:
undetectable
5x80B-2b4wA:
undetectable		 5x80A-2b4wA:
18.81
5x80B-2b4wA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.42A 6gbnA-2b4wA:
undetectable		 6gbnA-2b4wA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_1
(-)		 2b4w HYPOTHETICAL
PROTEIN, CONSERVED
(Leishmania
major) 		5 / 12 LEU A  62
LYS A  40
LEU A 122
GLY A 117
PHE A  37
 None
 1.42A 6gbnD-2b4wA:
undetectable		 6gbnD-2b4wA:
22.73