SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 12 ILE I 325
ALA I 427
LEU I 409
LEU I  78
PRO I  80
 None
 1.03A 1dhjB-2b4xI:
undetectable		 1dhjB-2b4xI:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 12 ALA I  86
ILE I  83
PHE I 344
LEU I 340
LEU I 102
 None
 1.15A 1dtlA-2b4xI:
undetectable		 1dtlA-2b4xI:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 12 ILE I 325
ALA I 427
LEU I 409
LEU I  78
PRO I  80
 None
 1.12A 1jolB-2b4xI:
undetectable		 1jolB-2b4xI:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 1k2tA-2b4xI:
undetectable
1k2tB-2b4xI:
undetectable		 1k2tA-2b4xI:
21.58
1k2tB-2b4xI:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 1k2tA-2b4xI:
undetectable
1k2tB-2b4xI:
undetectable		 1k2tA-2b4xI:
21.58
1k2tB-2b4xI:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 1lzxA-2b4xI:
undetectable
1lzxB-2b4xI:
undetectable		 1lzxA-2b4xI:
21.58
1lzxB-2b4xI:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 1m00A-2b4xI:
undetectable
1m00B-2b4xI:
undetectable		 1m00A-2b4xI:
21.58
1m00B-2b4xI:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 1mmvA-2b4xI:
undetectable
1mmvB-2b4xI:
undetectable		 1mmvA-2b4xI:
21.58
1mmvB-2b4xI:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		3 / 3 LEU I 292
VAL I 295
LEU I 299
 None
 0.32A 1mz9B-2b4xI:
undetectable		 1mz9B-2b4xI:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 1om4A-2b4xI:
undetectable
1om4B-2b4xI:
undetectable		 1om4A-2b4xI:
22.01
1om4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 1p6jA-2b4xI:
undetectable
1p6jB-2b4xI:
undetectable		 1p6jA-2b4xI:
21.97
1p6jB-2b4xI:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 1p6kA-2b4xI:
undetectable
1p6kB-2b4xI:
undetectable		 1p6kA-2b4xI:
21.97
1p6kB-2b4xI:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 1rs6A-2b4xI:
undetectable
1rs6B-2b4xI:
undetectable		 1rs6A-2b4xI:
21.97
1rs6B-2b4xI:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.45A 1rs7A-2b4xI:
undetectable
1rs7B-2b4xI:
undetectable		 1rs7A-2b4xI:
21.97
1rs7B-2b4xI:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 1rs7A-2b4xI:
undetectable
1rs7B-2b4xI:
undetectable		 1rs7A-2b4xI:
21.97
1rs7B-2b4xI:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 1zzqA-2b4xI:
undetectable
1zzqB-2b4xI:
undetectable		 1zzqA-2b4xI:
21.61
1zzqB-2b4xI:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 2g6hA-2b4xI:
undetectable
2g6hB-2b4xI:
undetectable		 2g6hA-2b4xI:
21.61
2g6hB-2b4xI:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 2g6kA-2b4xI:
undetectable
2g6kB-2b4xI:
undetectable		 2g6kA-2b4xI:
21.61
2g6kB-2b4xI:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX3_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 2hx3A-2b4xI:
undetectable
2hx3B-2b4xI:
undetectable		 2hx3A-2b4xI:
22.01
2hx3B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 2hx4A-2b4xI:
undetectable
2hx4B-2b4xI:
undetectable		 2hx4A-2b4xI:
22.01
2hx4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX4_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 2hx4A-2b4xI:
undetectable
2hx4B-2b4xI:
undetectable		 2hx4A-2b4xI:
22.01
2hx4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TYR I 131
SER I  82
THR I  85
ASN I 144
 None
 0.91A 2i91A-2b4xI:
undetectable		 2i91A-2b4xI:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TYR I 131
SER I  82
THR I  85
ASN I 144
 None
 0.90A 2i91B-2b4xI:
undetectable		 2i91B-2b4xI:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		3 / 3 LEU I 335
LEU I  78
PHE I 106
 None
 0.57A 2pgrA-2b4xI:
undetectable		 2pgrA-2b4xI:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 THR I  44
ALA I  43
ARG I 129
PRO I 416
 None
 1.39A 2ql8A-2b4xI:
undetectable
2ql8B-2b4xI:
undetectable		 2ql8A-2b4xI:
14.29
2ql8B-2b4xI:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 THR I 419
GLU I 414
PHE I 221
ILE I 219
 None
 1.37A 2w98B-2b4xI:
undetectable		 2w98B-2b4xI:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3M_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3b3mA-2b4xI:
undetectable
3b3mB-2b4xI:
undetectable		 3b3mA-2b4xI:
22.01
3b3mB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3b3nA-2b4xI:
undetectable
3b3nB-2b4xI:
undetectable		 3b3nA-2b4xI:
22.01
3b3nB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3b3nA-2b4xI:
undetectable
3b3nB-2b4xI:
undetectable		 3b3nA-2b4xI:
22.01
3b3nB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3b3oA-2b4xI:
undetectable
3b3oB-2b4xI:
undetectable		 3b3oA-2b4xI:
22.01
3b3oB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3O_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3b3oA-2b4xI:
undetectable
3b3oB-2b4xI:
undetectable		 3b3oA-2b4xI:
22.01
3b3oB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3b3pA-2b4xI:
undetectable
3b3pB-2b4xI:
undetectable		 3b3pA-2b4xI:
22.01
3b3pB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3b3pA-2b4xI:
undetectable
3b3pB-2b4xI:
undetectable		 3b3pA-2b4xI:
22.01
3b3pB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 3hsnA-2b4xI:
undetectable
3hsnB-2b4xI:
undetectable		 3hsnA-2b4xI:
22.01
3hsnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3hsnA-2b4xI:
undetectable
3hsnB-2b4xI:
undetectable		 3hsnA-2b4xI:
22.01
3hsnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 3hsoA-2b4xI:
undetectable
3hsoB-2b4xI:
undetectable		 3hsoA-2b4xI:
22.01
3hsoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3hsoA-2b4xI:
undetectable
3hsoB-2b4xI:
undetectable		 3hsoA-2b4xI:
22.01
3hsoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3hspA-2b4xI:
undetectable
3hspB-2b4xI:
undetectable		 3hspA-2b4xI:
22.01
3hspB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3jt3A-2b4xI:
undetectable
3jt3B-2b4xI:
undetectable		 3jt3A-2b4xI:
22.01
3jt3B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3jt3A-2b4xI:
undetectable
3jt3B-2b4xI:
undetectable		 3jt3A-2b4xI:
22.01
3jt3B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3jt4A-2b4xI:
undetectable
3jt4B-2b4xI:
undetectable		 3jt4A-2b4xI:
22.01
3jt4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3jt5A-2b4xI:
undetectable
3jt5B-2b4xI:
undetectable		 3jt5A-2b4xI:
22.01
3jt5B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3jt5A-2b4xI:
undetectable
3jt5B-2b4xI:
undetectable		 3jt5A-2b4xI:
22.01
3jt5B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3jt7A-2b4xI:
undetectable
3jt7B-2b4xI:
undetectable		 3jt7A-2b4xI:
22.01
3jt7B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3jt8A-2b4xI:
undetectable
3jt8B-2b4xI:
undetectable		 3jt8A-2b4xI:
22.01
3jt8B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3jwsA-2b4xI:
undetectable
3jwsB-2b4xI:
undetectable		 3jwsA-2b4xI:
22.27
3jwsB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWS_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 3jwsA-2b4xI:
undetectable
3jwsB-2b4xI:
undetectable		 3jwsA-2b4xI:
22.27
3jwsB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3jwtA-2b4xI:
undetectable
3jwtB-2b4xI:
undetectable		 3jwtA-2b4xI:
22.27
3jwtB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3jwtA-2b4xI:
undetectable
3jwtB-2b4xI:
undetectable		 3jwtA-2b4xI:
22.27
3jwtB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3jwuA-2b4xI:
undetectable
3jwuB-2b4xI:
undetectable		 3jwuA-2b4xI:
22.27
3jwuB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3jwuA-2b4xI:
undetectable
3jwuB-2b4xI:
undetectable		 3jwuA-2b4xI:
22.27
3jwuB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3jwvA-2b4xI:
undetectable
3jwvB-2b4xI:
undetectable		 3jwvA-2b4xI:
22.27
3jwvB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3jwvA-2b4xI:
undetectable
3jwvB-2b4xI:
undetectable		 3jwvA-2b4xI:
22.27
3jwvB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3jx0A-2b4xI:
undetectable
3jx0B-2b4xI:
undetectable		 3jx0A-2b4xI:
22.01
3jx0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 GLY I 339
PHE I 123
PHE I 106
PHE I 108
 None
 0.93A 3ko0B-2b4xI:
undetectable
3ko0J-2b4xI:
0.0		 3ko0B-2b4xI:
15.12
3ko0J-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 ILE I 420
PHE I 106
PHE I 108
PHE I 123
 None
 0.88A 3ko0B-2b4xI:
undetectable
3ko0J-2b4xI:
0.0		 3ko0B-2b4xI:
15.12
3ko0J-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 GLY I 339
PHE I 123
PHE I 106
PHE I 108
 None
 0.78A 3ko0D-2b4xI:
undetectable
3ko0E-2b4xI:
undetectable		 3ko0D-2b4xI:
15.12
3ko0E-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 PHE I 106
PHE I 108
GLY I 339
PHE I 123
 None
 0.80A 3ko0B-2b4xI:
undetectable
3ko0J-2b4xI:
undetectable		 3ko0B-2b4xI:
15.12
3ko0J-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 GLY I 339
PHE I 123
PHE I 106
PHE I 108
 None
 0.90A 3ko0K-2b4xI:
0.0
3ko0S-2b4xI:
0.0		 3ko0K-2b4xI:
15.12
3ko0S-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 ILE I 420
PHE I 106
PHE I 108
PHE I 123
 None
 0.91A 3ko0K-2b4xI:
0.0
3ko0S-2b4xI:
0.0		 3ko0K-2b4xI:
15.12
3ko0S-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 GLY I 339
PHE I 123
PHE I 106
PHE I 108
 None
 0.88A 3ko0L-2b4xI:
undetectable
3ko0N-2b4xI:
undetectable		 3ko0L-2b4xI:
15.12
3ko0N-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 8 GLY I 339
PHE I 123
PHE I 106
PHE I 108
 None
 0.83A 3ko0O-2b4xI:
undetectable
3ko0Q-2b4xI:
0.0		 3ko0O-2b4xI:
15.12
3ko0Q-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 PHE I 106
PHE I 108
GLY I 339
PHE I 123
 None
 0.82A 3ko0K-2b4xI:
undetectable
3ko0S-2b4xI:
undetectable		 3ko0K-2b4xI:
15.12
3ko0S-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 PHE I 106
PHE I 108
GLY I 339
PHE I 123
 None
 0.92A 3ko0R-2b4xI:
undetectable
3ko0T-2b4xI:
0.0		 3ko0R-2b4xI:
15.12
3ko0T-2b4xI:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 ILE I 412
VAL I 410
LEU I 283
LEU I 272
 None
 0.89A 3kp6A-2b4xI:
0.4
3kp6B-2b4xI:
undetectable		 3kp6A-2b4xI:
20.57
3kp6B-2b4xI:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3n2rA-2b4xI:
undetectable
3n2rB-2b4xI:
undetectable		 3n2rA-2b4xI:
22.01
3n2rB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3n2rA-2b4xI:
undetectable
3n2rB-2b4xI:
undetectable		 3n2rA-2b4xI:
22.01
3n2rB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3n5vA-2b4xI:
undetectable
3n5vB-2b4xI:
undetectable		 3n5vA-2b4xI:
22.01
3n5vB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3n5yA-2b4xI:
undetectable
3n5yB-2b4xI:
undetectable		 3n5yA-2b4xI:
22.01
3n5yB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3n5yA-2b4xI:
undetectable
3n5yB-2b4xI:
undetectable		 3n5yA-2b4xI:
22.01
3n5yB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3n5zA-2b4xI:
undetectable
3n5zB-2b4xI:
undetectable		 3n5zA-2b4xI:
22.01
3n5zB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3n5zA-2b4xI:
undetectable
3n5zB-2b4xI:
undetectable		 3n5zA-2b4xI:
22.01
3n5zB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3n61A-2b4xI:
undetectable
3n61B-2b4xI:
undetectable		 3n61A-2b4xI:
22.01
3n61B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 3n65A-2b4xI:
0.0
3n65B-2b4xI:
0.0		 3n65A-2b4xI:
22.86
3n65B-2b4xI:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 11 THR I  90
LEU I 215
ASN I 217
LEU I 335
LEU I 102
 None
 1.33A 3ndvA-2b4xI:
undetectable
3ndvB-2b4xI:
undetectable		 3ndvA-2b4xI:
22.15
3ndvB-2b4xI:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 11 LEU I 102
THR I  90
LEU I 215
ASN I 217
LEU I 335
 None
 1.32A 3ndvA-2b4xI:
undetectable
3ndvB-2b4xI:
undetectable		 3ndvA-2b4xI:
22.15
3ndvB-2b4xI:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 3nlkA-2b4xI:
undetectable
3nlkB-2b4xI:
undetectable		 3nlkA-2b4xI:
22.27
3nlkB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLK_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3nlkA-2b4xI:
undetectable
3nlkB-2b4xI:
undetectable		 3nlkA-2b4xI:
22.27
3nlkB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3nlmA-2b4xI:
undetectable
3nlmB-2b4xI:
undetectable		 3nlmA-2b4xI:
22.01
3nlmB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 3nlnA-2b4xI:
undetectable
3nlnB-2b4xI:
undetectable		 3nlnA-2b4xI:
22.27
3nlnB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3nloA-2b4xI:
undetectable
3nloB-2b4xI:
undetectable		 3nloA-2b4xI:
22.27
3nloB-2b4xI:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3nlvA-2b4xI:
undetectable
3nlvB-2b4xI:
undetectable		 3nlvA-2b4xI:
22.01
3nlvB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3nlvA-2b4xI:
undetectable
3nlvB-2b4xI:
undetectable		 3nlvA-2b4xI:
22.01
3nlvB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3nlwA-2b4xI:
undetectable
3nlwB-2b4xI:
undetectable		 3nlwA-2b4xI:
22.01
3nlwB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3nlwA-2b4xI:
undetectable
3nlwB-2b4xI:
undetectable		 3nlwA-2b4xI:
22.01
3nlwB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3nlxA-2b4xI:
undetectable
3nlxB-2b4xI:
undetectable		 3nlxA-2b4xI:
22.01
3nlxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3nlzA-2b4xI:
undetectable
3nlzB-2b4xI:
undetectable		 3nlzA-2b4xI:
22.01
3nlzB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NM0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3nm0A-2b4xI:
undetectable
3nm0B-2b4xI:
undetectable		 3nm0A-2b4xI:
22.01
3nm0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3nnyA-2b4xI:
undetectable
3nnyB-2b4xI:
undetectable		 3nnyA-2b4xI:
22.01
3nnyB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3nnzA-2b4xI:
undetectable
3nnzB-2b4xI:
undetectable		 3nnzA-2b4xI:
22.01
3nnzB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNZ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3nnzA-2b4xI:
undetectable
3nnzB-2b4xI:
undetectable		 3nnzA-2b4xI:
22.01
3nnzB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 ARG I 413
ILE I 421
LEU I 126
THR I  44
 None
 1.21A 3nxuA-2b4xI:
undetectable		 3nxuA-2b4xI:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3pneA-2b4xI:
undetectable
3pneB-2b4xI:
undetectable		 3pneA-2b4xI:
22.01
3pneB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3pneA-2b4xI:
undetectable
3pneB-2b4xI:
undetectable		 3pneA-2b4xI:
22.01
3pneB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3pnfA-2b4xI:
undetectable
3pnfB-2b4xI:
undetectable		 3pnfA-2b4xI:
22.01
3pnfB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 3pngA-2b4xI:
undetectable
3pngB-2b4xI:
undetectable		 3pngA-2b4xI:
22.01
3pngB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q99_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 3q99A-2b4xI:
undetectable
3q99B-2b4xI:
undetectable		 3q99A-2b4xI:
22.01
3q99B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 165
LEU I  51
ASN I  55
ILE I 119
 None
 1.02A 3rfmA-2b4xI:
undetectable		 3rfmA-2b4xI:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 10 TYR I  63
ALA I 293
ASP I  72
ALA I 242
SER I 291
 None
 1.43A 3rodC-2b4xI:
undetectable		 3rodC-2b4xI:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 3rqjA-2b4xI:
undetectable
3rqjB-2b4xI:
undetectable		 3rqjA-2b4xI:
22.01
3rqjB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3rqlA-2b4xI:
undetectable
3rqlB-2b4xI:
undetectable		 3rqlA-2b4xI:
22.01
3rqlB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 3rqmA-2b4xI:
undetectable
3rqmB-2b4xI:
undetectable		 3rqmA-2b4xI:
22.01
3rqmB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 3rqnA-2b4xI:
undetectable
3rqnB-2b4xI:
undetectable		 3rqnA-2b4xI:
22.01
3rqnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3svpA-2b4xI:
undetectable
3svpB-2b4xI:
undetectable		 3svpA-2b4xI:
22.01
3svpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3svpA-2b4xI:
undetectable
3svpB-2b4xI:
undetectable		 3svpA-2b4xI:
22.01
3svpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYL_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 3tylA-2b4xI:
undetectable
3tylB-2b4xI:
undetectable		 3tylA-2b4xI:
22.01
3tylB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 3tymA-2b4xI:
undetectable
3tymB-2b4xI:
undetectable		 3tymA-2b4xI:
22.01
3tymB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3tynA-2b4xI:
undetectable
3tynB-2b4xI:
undetectable		 3tynA-2b4xI:
22.01
3tynB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3tynA-2b4xI:
undetectable
3tynB-2b4xI:
undetectable		 3tynA-2b4xI:
22.01
3tynB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3tyoA-2b4xI:
undetectable
3tyoB-2b4xI:
undetectable		 3tyoA-2b4xI:
22.01
3tyoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 3ufoA-2b4xI:
undetectable
3ufoB-2b4xI:
undetectable		 3ufoA-2b4xI:
22.01
3ufoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3ufpA-2b4xI:
undetectable
3ufpB-2b4xI:
undetectable		 3ufpA-2b4xI:
22.01
3ufpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 3ufqA-2b4xI:
undetectable
3ufqB-2b4xI:
undetectable		 3ufqA-2b4xI:
22.01
3ufqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.44A 3ufqA-2b4xI:
undetectable
3ufqB-2b4xI:
undetectable		 3ufqA-2b4xI:
22.01
3ufqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3ufrA-2b4xI:
undetectable
3ufrB-2b4xI:
undetectable		 3ufrA-2b4xI:
22.01
3ufrB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 3ufsA-2b4xI:
undetectable
3ufsB-2b4xI:
undetectable		 3ufsA-2b4xI:
22.01
3ufsB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 3ufsA-2b4xI:
undetectable
3ufsB-2b4xI:
undetectable		 3ufsA-2b4xI:
22.01
3ufsB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3uftA-2b4xI:
undetectable
3uftB-2b4xI:
undetectable		 3uftA-2b4xI:
22.01
3uftB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 3ufuA-2b4xI:
undetectable
3ufuB-2b4xI:
undetectable		 3ufuA-2b4xI:
22.01
3ufuB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 3ufvA-2b4xI:
undetectable
3ufvB-2b4xI:
undetectable		 3ufvA-2b4xI:
22.01
3ufvB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 3ufwA-2b4xI:
undetectable
3ufwB-2b4xI:
undetectable		 3ufwA-2b4xI:
22.01
3ufwB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4c39A-2b4xI:
undetectable
4c39B-2b4xI:
undetectable		 4c39A-2b4xI:
22.01
4c39B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4c39A-2b4xI:
undetectable
4c39B-2b4xI:
undetectable		 4c39A-2b4xI:
22.01
4c39B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4camA-2b4xI:
undetectable
4camB-2b4xI:
undetectable		 4camA-2b4xI:
22.01
4camB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4canA-2b4xI:
undetectable
4canB-2b4xI:
undetectable		 4canA-2b4xI:
22.01
4canB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4caoA-2b4xI:
undetectable
4caoB-2b4xI:
undetectable		 4caoA-2b4xI:
22.01
4caoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4capA-2b4xI:
undetectable
4capB-2b4xI:
undetectable		 4capA-2b4xI:
22.01
4capB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4caqA-2b4xI:
undetectable
4caqB-2b4xI:
undetectable		 4caqA-2b4xI:
22.01
4caqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4caqA-2b4xI:
undetectable
4caqB-2b4xI:
undetectable		 4caqA-2b4xI:
22.01
4caqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4cdtA-2b4xI:
undetectable
4cdtB-2b4xI:
undetectable		 4cdtA-2b4xI:
22.01
4cdtB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 4cdtA-2b4xI:
undetectable
4cdtB-2b4xI:
undetectable		 4cdtA-2b4xI:
22.01
4cdtB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4ctpA-2b4xI:
undetectable
4ctpB-2b4xI:
undetectable		 4ctpA-2b4xI:
22.01
4ctpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4ctqA-2b4xI:
undetectable
4ctqB-2b4xI:
undetectable		 4ctqA-2b4xI:
22.01
4ctqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4ctrA-2b4xI:
undetectable
4ctrB-2b4xI:
undetectable		 4ctrA-2b4xI:
22.01
4ctrB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4ctrA-2b4xI:
undetectable
4ctrB-2b4xI:
undetectable		 4ctrA-2b4xI:
22.01
4ctrB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4cttA-2b4xI:
undetectable
4cttB-2b4xI:
undetectable		 4cttA-2b4xI:
22.01
4cttB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4cttA-2b4xI:
undetectable
4cttB-2b4xI:
undetectable		 4cttA-2b4xI:
22.01
4cttB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4ctuA-2b4xI:
undetectable
4ctuB-2b4xI:
undetectable		 4ctuA-2b4xI:
22.01
4ctuB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTV_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4ctvA-2b4xI:
undetectable
4ctvB-2b4xI:
undetectable		 4ctvA-2b4xI:
22.01
4ctvB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTW_B_H4BB1720_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4ctwA-2b4xI:
undetectable
4ctwB-2b4xI:
undetectable		 4ctwA-2b4xI:
22.01
4ctwB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTX_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4ctxA-2b4xI:
undetectable
4ctxB-2b4xI:
undetectable		 4ctxA-2b4xI:
22.01
4ctxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4cx5A-2b4xI:
undetectable
4cx5B-2b4xI:
undetectable		 4cx5A-2b4xI:
22.01
4cx5B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4cx5A-2b4xI:
undetectable
4cx5B-2b4xI:
undetectable		 4cx5A-2b4xI:
22.01
4cx5B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4cx6A-2b4xI:
undetectable
4cx6B-2b4xI:
undetectable		 4cx6A-2b4xI:
22.01
4cx6B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4cx6A-2b4xI:
undetectable
4cx6B-2b4xI:
undetectable		 4cx6A-2b4xI:
22.01
4cx6B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4d1nA-2b4xI:
undetectable
4d1nB-2b4xI:
undetectable		 4d1nA-2b4xI:
22.20
4d1nB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1N_D_H4BD760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4d1nC-2b4xI:
undetectable
4d1nD-2b4xI:
undetectable		 4d1nC-2b4xI:
22.20
4d1nD-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4d2yA-2b4xI:
undetectable
4d2yB-2b4xI:
undetectable		 4d2yA-2b4xI:
22.01
4d2yB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 4d2yA-2b4xI:
undetectable
4d2yB-2b4xI:
undetectable		 4d2yA-2b4xI:
22.01
4d2yB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4d2zA-2b4xI:
undetectable
4d2zB-2b4xI:
undetectable		 4d2zA-2b4xI:
22.01
4d2zB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4d2zA-2b4xI:
undetectable
4d2zB-2b4xI:
undetectable		 4d2zA-2b4xI:
22.01
4d2zB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 4d30A-2b4xI:
undetectable
4d30B-2b4xI:
undetectable		 4d30A-2b4xI:
22.01
4d30B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4d31A-2b4xI:
undetectable
4d31B-2b4xI:
undetectable		 4d31A-2b4xI:
22.01
4d31B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4d32A-2b4xI:
undetectable
4d32B-2b4xI:
undetectable		 4d32A-2b4xI:
22.01
4d32B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3B_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4d3bA-2b4xI:
undetectable
4d3bB-2b4xI:
undetectable		 4d3bA-2b4xI:
22.01
4d3bB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4d7oA-2b4xI:
undetectable
4d7oB-2b4xI:
undetectable		 4d7oA-2b4xI:
22.01
4d7oB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4fvxA-2b4xI:
undetectable
4fvxB-2b4xI:
undetectable		 4fvxA-2b4xI:
22.01
4fvxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4fvyA-2b4xI:
undetectable
4fvyB-2b4xI:
undetectable		 4fvyA-2b4xI:
22.01
4fvyB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 4fvzA-2b4xI:
undetectable
4fvzB-2b4xI:
undetectable		 4fvzA-2b4xI:
22.01
4fvzB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FW0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4fw0A-2b4xI:
undetectable
4fw0B-2b4xI:
undetectable		 4fw0A-2b4xI:
22.01
4fw0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 5 ALA I  86
ILE I 219
LEU I  81
ASN I 144
 None
 1.07A 4g19A-2b4xI:
undetectable		 4g19A-2b4xI:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4gqeA-2b4xI:
undetectable
4gqeB-2b4xI:
undetectable		 4gqeA-2b4xI:
22.01
4gqeB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 MET I 103
LEU I  92
ALA I  88
THR I  85
 None
 0.84A 4ik7A-2b4xI:
undetectable		 4ik7A-2b4xI:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4imuA-2b4xI:
0.0
4imuB-2b4xI:
0.0		 4imuA-2b4xI:
22.01
4imuB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4jsfA-2b4xI:
undetectable
4jsfB-2b4xI:
undetectable		 4jsfA-2b4xI:
22.01
4jsfB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 4jsgA-2b4xI:
undetectable
4jsgB-2b4xI:
undetectable		 4jsgA-2b4xI:
22.01
4jsgB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4jsgA-2b4xI:
undetectable
4jsgB-2b4xI:
undetectable		 4jsgA-2b4xI:
22.01
4jsgB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSH_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 4jshA-2b4xI:
0.0
4jshB-2b4xI:
0.0		 4jshA-2b4xI:
22.01
4jshB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 4jsiA-2b4xI:
undetectable
4jsiB-2b4xI:
undetectable		 4jsiA-2b4xI:
22.01
4jsiB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4jsjA-2b4xI:
undetectable
4jsjB-2b4xI:
undetectable		 4jsjA-2b4xI:
22.01
4jsjB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4k5eA-2b4xI:
undetectable
4k5eB-2b4xI:
undetectable		 4k5eA-2b4xI:
22.01
4k5eB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5E_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4k5eA-2b4xI:
undetectable
4k5eB-2b4xI:
undetectable		 4k5eA-2b4xI:
22.01
4k5eB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4k5fA-2b4xI:
undetectable
4k5fB-2b4xI:
undetectable		 4k5fA-2b4xI:
22.01
4k5fB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 4k5fA-2b4xI:
undetectable
4k5fB-2b4xI:
undetectable		 4k5fA-2b4xI:
22.01
4k5fB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4k5gA-2b4xI:
undetectable
4k5gB-2b4xI:
undetectable		 4k5gA-2b4xI:
22.01
4k5gB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4k5gA-2b4xI:
undetectable
4k5gB-2b4xI:
undetectable		 4k5gA-2b4xI:
22.01
4k5gB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4kciA-2b4xI:
undetectable
4kciB-2b4xI:
undetectable		 4kciA-2b4xI:
22.01
4kciB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4kciA-2b4xI:
undetectable
4kciB-2b4xI:
undetectable		 4kciA-2b4xI:
22.01
4kciB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4kcjA-2b4xI:
undetectable
4kcjB-2b4xI:
undetectable		 4kcjA-2b4xI:
22.01
4kcjB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 4kcjA-2b4xI:
undetectable
4kcjB-2b4xI:
undetectable		 4kcjA-2b4xI:
22.01
4kcjB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 4kckA-2b4xI:
undetectable
4kckB-2b4xI:
undetectable		 4kckA-2b4xI:
22.01
4kckB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 4kckA-2b4xI:
undetectable
4kckB-2b4xI:
undetectable		 4kckA-2b4xI:
22.01
4kckB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4kclA-2b4xI:
undetectable
4kclB-2b4xI:
undetectable		 4kclA-2b4xI:
22.01
4kclB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4kclA-2b4xI:
undetectable
4kclB-2b4xI:
undetectable		 4kclA-2b4xI:
22.01
4kclB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 4kcmA-2b4xI:
undetectable
4kcmB-2b4xI:
undetectable		 4kcmA-2b4xI:
22.01
4kcmB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4kcnA-2b4xI:
undetectable
4kcnB-2b4xI:
undetectable		 4kcnA-2b4xI:
22.01
4kcnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4kcnA-2b4xI:
undetectable
4kcnB-2b4xI:
undetectable		 4kcnA-2b4xI:
22.01
4kcnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4kcoA-2b4xI:
undetectable
4kcoB-2b4xI:
undetectable		 4kcoA-2b4xI:
22.01
4kcoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 4kcoA-2b4xI:
undetectable
4kcoB-2b4xI:
undetectable		 4kcoA-2b4xI:
22.01
4kcoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4luxA-2b4xI:
undetectable
4luxB-2b4xI:
undetectable		 4luxA-2b4xI:
22.01
4luxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4luxA-2b4xI:
undetectable
4luxB-2b4xI:
undetectable		 4luxA-2b4xI:
22.01
4luxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 LEU I 362
LEU I 146
PHE I 108
MET I 103
 None
 1.05A 4o1zA-2b4xI:
undetectable		 4o1zA-2b4xI:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		3 / 3 LEU I 270
LEU I 292
ASN I 405
 None
 0.72A 4otwA-2b4xI:
undetectable		 4otwA-2b4xI:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 4ugzA-2b4xI:
undetectable
4ugzB-2b4xI:
undetectable		 4ugzA-2b4xI:
22.01
4ugzB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4uh0A-2b4xI:
undetectable
4uh0B-2b4xI:
undetectable		 4uh0A-2b4xI:
22.01
4uh0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 4uh0A-2b4xI:
undetectable
4uh0B-2b4xI:
undetectable		 4uh0A-2b4xI:
22.01
4uh0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4uh1A-2b4xI:
undetectable
4uh1B-2b4xI:
undetectable		 4uh1A-2b4xI:
22.01
4uh1B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 4uh1A-2b4xI:
undetectable
4uh1B-2b4xI:
undetectable		 4uh1A-2b4xI:
22.01
4uh1B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4uh2A-2b4xI:
undetectable
4uh2B-2b4xI:
undetectable		 4uh2A-2b4xI:
22.01
4uh2B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 4uh2A-2b4xI:
undetectable
4uh2B-2b4xI:
undetectable		 4uh2A-2b4xI:
22.01
4uh2B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 4uh4A-2b4xI:
undetectable
4uh4B-2b4xI:
undetectable		 4uh4A-2b4xI:
22.01
4uh4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4uh4A-2b4xI:
undetectable
4uh4B-2b4xI:
undetectable		 4uh4A-2b4xI:
22.01
4uh4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4uh5A-2b4xI:
undetectable
4uh5B-2b4xI:
undetectable		 4uh5A-2b4xI:
22.20
4uh5B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4uh5A-2b4xI:
undetectable
4uh5B-2b4xI:
undetectable		 4uh5A-2b4xI:
22.20
4uh5B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4uh6A-2b4xI:
undetectable
4uh6B-2b4xI:
undetectable		 4uh6A-2b4xI:
22.20
4uh6B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4upmA-2b4xI:
undetectable
4upmB-2b4xI:
undetectable		 4upmA-2b4xI:
22.01
4upmB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 4upnA-2b4xI:
undetectable
4upnB-2b4xI:
undetectable		 4upnA-2b4xI:
22.01
4upnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 4upnA-2b4xI:
undetectable
4upnB-2b4xI:
undetectable		 4upnA-2b4xI:
22.01
4upnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4upoA-2b4xI:
undetectable
4upoB-2b4xI:
undetectable		 4upoA-2b4xI:
22.01
4upoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 4upoA-2b4xI:
undetectable
4upoB-2b4xI:
undetectable		 4upoA-2b4xI:
22.01
4upoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4uppA-2b4xI:
undetectable
4uppB-2b4xI:
undetectable		 4uppA-2b4xI:
22.01
4uppB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 4uppA-2b4xI:
undetectable
4uppB-2b4xI:
undetectable		 4uppA-2b4xI:
22.01
4uppB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4v3uA-2b4xI:
undetectable
4v3uB-2b4xI:
undetectable		 4v3uA-2b4xI:
22.20
4v3uB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_C_H4BC760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4v3uC-2b4xI:
undetectable
4v3uD-2b4xI:
undetectable		 4v3uC-2b4xI:
22.20
4v3uD-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 4v3vA-2b4xI:
undetectable
4v3vB-2b4xI:
undetectable		 4v3vA-2b4xI:
22.01
4v3vB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 4v3yA-2b4xI:
undetectable
4v3yB-2b4xI:
undetectable		 4v3yA-2b4xI:
22.01
4v3yB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5ad4A-2b4xI:
undetectable
5ad4B-2b4xI:
undetectable		 5ad4A-2b4xI:
22.01
5ad4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.43A 5ad4A-2b4xI:
undetectable
5ad4B-2b4xI:
undetectable		 5ad4A-2b4xI:
22.01
5ad4B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5ad5A-2b4xI:
undetectable
5ad5B-2b4xI:
undetectable		 5ad5A-2b4xI:
22.01
5ad5B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 5ad5A-2b4xI:
undetectable
5ad5B-2b4xI:
undetectable		 5ad5A-2b4xI:
22.01
5ad5B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5ad6A-2b4xI:
undetectable
5ad6B-2b4xI:
undetectable		 5ad6A-2b4xI:
22.01
5ad6B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 5ad6A-2b4xI:
undetectable
5ad6B-2b4xI:
undetectable		 5ad6A-2b4xI:
22.01
5ad6B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD7_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5ad7A-2b4xI:
undetectable
5ad7B-2b4xI:
undetectable		 5ad7A-2b4xI:
22.01
5ad7B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 5ad8A-2b4xI:
undetectable
5ad8B-2b4xI:
undetectable		 5ad8A-2b4xI:
22.01
5ad8B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.44A 5ad9A-2b4xI:
undetectable
5ad9B-2b4xI:
undetectable		 5ad9A-2b4xI:
22.01
5ad9B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5adaA-2b4xI:
undetectable
5adaB-2b4xI:
undetectable		 5adaA-2b4xI:
22.01
5adaB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5adaA-2b4xI:
undetectable
5adaB-2b4xI:
undetectable		 5adaA-2b4xI:
22.01
5adaB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5adbA-2b4xI:
0.0
5adbB-2b4xI:
0.0		 5adbA-2b4xI:
22.01
5adbB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5adcA-2b4xI:
undetectable
5adcB-2b4xI:
undetectable		 5adcA-2b4xI:
22.01
5adcB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADF_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 5adfA-2b4xI:
undetectable
5adfB-2b4xI:
undetectable		 5adfA-2b4xI:
22.20
5adfB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5adgA-2b4xI:
undetectable
5adgB-2b4xI:
undetectable		 5adgA-2b4xI:
22.20
5adgB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5adgA-2b4xI:
undetectable
5adgB-2b4xI:
undetectable		 5adgA-2b4xI:
22.20
5adgB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 5adiA-2b4xI:
undetectable
5adiB-2b4xI:
0.5		 5adiA-2b4xI:
22.20
5adiB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGK_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 5agkA-2b4xI:
undetectable
5agkB-2b4xI:
undetectable		 5agkA-2b4xI:
22.01
5agkB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 5aglA-2b4xI:
undetectable
5aglB-2b4xI:
undetectable		 5aglA-2b4xI:
22.01
5aglB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 5agmA-2b4xI:
undetectable
5agmB-2b4xI:
undetectable		 5agmA-2b4xI:
22.01
5agmB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5agnA-2b4xI:
undetectable
5agnB-2b4xI:
undetectable		 5agnA-2b4xI:
22.01
5agnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5agnA-2b4xI:
undetectable
5agnB-2b4xI:
undetectable		 5agnA-2b4xI:
22.01
5agnB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5agoA-2b4xI:
undetectable
5agoB-2b4xI:
undetectable		 5agoA-2b4xI:
22.01
5agoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 5 PHE I 175
GLY I 148
ILE I 207
LEU I 213
 None
 0.85A 5dzkB-2b4xI:
undetectable
5dzkI-2b4xI:
undetectable
5dzkW-2b4xI:
undetectable		 5dzkB-2b4xI:
19.90
5dzkI-2b4xI:
18.03
5dzkW-2b4xI:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 12 ILE I 325
ALA I 427
LEU I 409
LEU I  78
PRO I  80
 None
 1.02A 5eajB-2b4xI:
undetectable		 5eajB-2b4xI:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 5fvpA-2b4xI:
undetectable
5fvpB-2b4xI:
undetectable		 5fvpA-2b4xI:
22.01
5fvpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 5fvpA-2b4xI:
undetectable
5fvpB-2b4xI:
undetectable		 5fvpA-2b4xI:
22.01
5fvpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 5fvqA-2b4xI:
undetectable
5fvqB-2b4xI:
undetectable		 5fvqA-2b4xI:
22.01
5fvqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5fvrA-2b4xI:
undetectable
5fvrB-2b4xI:
undetectable		 5fvrA-2b4xI:
22.01
5fvrB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5fvsA-2b4xI:
undetectable
5fvsB-2b4xI:
undetectable		 5fvsA-2b4xI:
22.01
5fvsB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5fvtA-2b4xI:
undetectable
5fvtB-2b4xI:
undetectable		 5fvtA-2b4xI:
22.01
5fvtB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 5fvuA-2b4xI:
undetectable
5fvuB-2b4xI:
undetectable		 5fvuA-2b4xI:
22.20
5fvuB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 5fvvA-2b4xI:
undetectable
5fvvB-2b4xI:
undetectable		 5fvvA-2b4xI:
22.20
5fvvB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 5fvwA-2b4xI:
undetectable
5fvwB-2b4xI:
undetectable		 5fvwA-2b4xI:
22.20
5fvwB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5fvxA-2b4xI:
undetectable
5fvxB-2b4xI:
undetectable		 5fvxA-2b4xI:
22.20
5fvxB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5fw0A-2b4xI:
undetectable
5fw0B-2b4xI:
undetectable		 5fw0A-2b4xI:
22.01
5fw0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5fw0A-2b4xI:
undetectable
5fw0B-2b4xI:
undetectable		 5fw0A-2b4xI:
22.01
5fw0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5g0nA-2b4xI:
undetectable
5g0nB-2b4xI:
undetectable		 5g0nA-2b4xI:
22.01
5g0nB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5g0oA-2b4xI:
undetectable
5g0oB-2b4xI:
undetectable		 5g0oA-2b4xI:
22.01
5g0oB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0O_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 5g0oA-2b4xI:
undetectable
5g0oB-2b4xI:
undetectable		 5g0oA-2b4xI:
22.01
5g0oB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 10 GLY I  93
TYR I 158
GLY I 353
LEU I 351
LEU I 213
 None
 1.00A 5hwkA-2b4xI:
undetectable		 5hwkA-2b4xI:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		5 / 10 GLY I  93
TYR I 158
GLY I 353
LEU I 351
LEU I 213
 None
 1.00A 5hwkB-2b4xI:
undetectable		 5hwkB-2b4xI:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		3 / 3 MET I 252
GLU I 374
ARG I 322
 None
 1.11A 5tjyA-2b4xI:
undetectable		 5tjyA-2b4xI:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		3 / 3 MET I 252
GLU I 374
ARG I 322
 None
 1.02A 5tjzA-2b4xI:
undetectable		 5tjzA-2b4xI:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5unrA-2b4xI:
undetectable
5unrB-2b4xI:
undetectable		 5unrA-2b4xI:
22.01
5unrB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 5unsA-2b4xI:
undetectable
5unsB-2b4xI:
undetectable		 5unsA-2b4xI:
22.01
5unsB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNS_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 5unsA-2b4xI:
undetectable
5unsB-2b4xI:
undetectable		 5unsA-2b4xI:
22.01
5unsB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5untA-2b4xI:
undetectable
5untB-2b4xI:
undetectable		 5untA-2b4xI:
22.01
5untB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5unuA-2b4xI:
undetectable
5unuB-2b4xI:
undetectable		 5unuA-2b4xI:
22.01
5unuB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5unuA-2b4xI:
undetectable
5unuB-2b4xI:
undetectable		 5unuA-2b4xI:
22.01
5unuB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 5unvA-2b4xI:
0.0
5unvB-2b4xI:
0.0		 5unvA-2b4xI:
22.01
5unvB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.44A 5unvA-2b4xI:
undetectable
5unvB-2b4xI:
undetectable		 5unvA-2b4xI:
22.01
5unvB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5unwA-2b4xI:
undetectable
5unwB-2b4xI:
undetectable		 5unwA-2b4xI:
22.01
5unwB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 5unwA-2b4xI:
undetectable
5unwB-2b4xI:
undetectable		 5unwA-2b4xI:
22.01
5unwB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.45A 5unxA-2b4xI:
undetectable
5unxB-2b4xI:
undetectable		 5unxA-2b4xI:
22.01
5unxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 5unxA-2b4xI:
undetectable
5unxB-2b4xI:
undetectable		 5unxA-2b4xI:
22.01
5unxB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5unyA-2b4xI:
undetectable
5unyB-2b4xI:
undetectable		 5unyA-2b4xI:
22.01
5unyB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5unyA-2b4xI:
undetectable
5unyB-2b4xI:
undetectable		 5unyA-2b4xI:
22.01
5unyB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5unzA-2b4xI:
undetectable
5unzB-2b4xI:
undetectable		 5unzA-2b4xI:
22.01
5unzB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5uo0A-2b4xI:
undetectable
5uo0B-2b4xI:
undetectable		 5uo0A-2b4xI:
22.01
5uo0B-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5uo1A-2b4xI:
undetectable
5uo1B-2b4xI:
undetectable		 5uo1A-2b4xI:
22.20
5uo1B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 5uo1A-2b4xI:
undetectable
5uo1B-2b4xI:
undetectable		 5uo1A-2b4xI:
22.20
5uo1B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 5uo2A-2b4xI:
undetectable
5uo2B-2b4xI:
undetectable		 5uo2A-2b4xI:
22.20
5uo2B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5uo3A-2b4xI:
undetectable
5uo3B-2b4xI:
undetectable		 5uo3A-2b4xI:
22.20
5uo3B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5uo3A-2b4xI:
undetectable
5uo3B-2b4xI:
undetectable		 5uo3A-2b4xI:
22.20
5uo3B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5uo4A-2b4xI:
undetectable
5uo4B-2b4xI:
undetectable		 5uo4A-2b4xI:
22.20
5uo4B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5uo4A-2b4xI:
undetectable
5uo4B-2b4xI:
undetectable		 5uo4A-2b4xI:
22.20
5uo4B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.47A 5uo5A-2b4xI:
undetectable
5uo5B-2b4xI:
undetectable		 5uo5A-2b4xI:
22.20
5uo5B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 5uo5A-2b4xI:
undetectable
5uo5B-2b4xI:
undetectable		 5uo5A-2b4xI:
22.20
5uo5B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 5uo6A-2b4xI:
undetectable
5uo6B-2b4xI:
undetectable		 5uo6A-2b4xI:
22.20
5uo6B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5uo7A-2b4xI:
undetectable
5uo7B-2b4xI:
undetectable		 5uo7A-2b4xI:
22.20
5uo7B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5vuiA-2b4xI:
undetectable
5vuiB-2b4xI:
undetectable		 5vuiA-2b4xI:
22.01
5vuiB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 5vuiA-2b4xI:
undetectable
5vuiB-2b4xI:
undetectable		 5vuiA-2b4xI:
22.01
5vuiB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5vukA-2b4xI:
undetectable
5vukB-2b4xI:
undetectable		 5vukA-2b4xI:
22.01
5vukB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5vukA-2b4xI:
undetectable
5vukB-2b4xI:
undetectable		 5vukA-2b4xI:
22.01
5vukB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUL_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 5vulA-2b4xI:
undetectable
5vulB-2b4xI:
undetectable		 5vulA-2b4xI:
22.01
5vulB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUM_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5vumA-2b4xI:
undetectable
5vumB-2b4xI:
undetectable		 5vumA-2b4xI:
22.01
5vumB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 5vunA-2b4xI:
undetectable
5vunB-2b4xI:
undetectable		 5vunA-2b4xI:
22.01
5vunB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5vunA-2b4xI:
undetectable
5vunB-2b4xI:
undetectable		 5vunA-2b4xI:
22.01
5vunB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5vuoA-2b4xI:
undetectable
5vuoB-2b4xI:
undetectable		 5vuoA-2b4xI:
22.01
5vuoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5vuoA-2b4xI:
undetectable
5vuoB-2b4xI:
undetectable		 5vuoA-2b4xI:
22.01
5vuoB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 5vupA-2b4xI:
undetectable
5vupB-2b4xI:
undetectable		 5vupA-2b4xI:
22.01
5vupB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUP_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 5vupA-2b4xI:
undetectable
5vupB-2b4xI:
undetectable		 5vupA-2b4xI:
22.01
5vupB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5vuqA-2b4xI:
undetectable
5vuqB-2b4xI:
undetectable		 5vuqA-2b4xI:
22.01
5vuqB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5vutA-2b4xI:
undetectable
5vutB-2b4xI:
undetectable		 5vutA-2b4xI:
22.01
5vutB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5vuuA-2b4xI:
undetectable
5vuuB-2b4xI:
undetectable		 5vuuA-2b4xI:
22.01
5vuuB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 5vuvA-2b4xI:
undetectable
5vuvB-2b4xI:
undetectable		 5vuvA-2b4xI:
22.20
5vuvB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 5vuwA-2b4xI:
undetectable
5vuwB-2b4xI:
undetectable		 5vuwA-2b4xI:
22.20
5vuwB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 5vuwA-2b4xI:
undetectable
5vuwB-2b4xI:
undetectable		 5vuwA-2b4xI:
22.20
5vuwB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5vuxA-2b4xI:
undetectable
5vuxB-2b4xI:
undetectable		 5vuxA-2b4xI:
22.20
5vuxB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 5vuyA-2b4xI:
undetectable
5vuyB-2b4xI:
undetectable		 5vuyA-2b4xI:
22.20
5vuyB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.45A 5vuyA-2b4xI:
undetectable
5vuyB-2b4xI:
undetectable		 5vuyA-2b4xI:
22.20
5vuyB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.50A 5vuzA-2b4xI:
undetectable
5vuzB-2b4xI:
undetectable		 5vuzA-2b4xI:
22.20
5vuzB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5vuzA-2b4xI:
undetectable
5vuzB-2b4xI:
undetectable		 5vuzA-2b4xI:
22.20
5vuzB-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 5vv0A-2b4xI:
undetectable
5vv0B-2b4xI:
undetectable		 5vv0A-2b4xI:
22.31
5vv0B-2b4xI:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 5vv2A-2b4xI:
undetectable
5vv2B-2b4xI:
undetectable		 5vv2A-2b4xI:
22.20
5vv2B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.50A 5vv3A-2b4xI:
undetectable
5vv3B-2b4xI:
undetectable		 5vv3A-2b4xI:
22.20
5vv3B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.46A 5vv4A-2b4xI:
undetectable
5vv4B-2b4xI:
undetectable		 5vv4A-2b4xI:
22.20
5vv4B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 5vv5A-2b4xI:
undetectable
5vv5B-2b4xI:
undetectable		 5vv5A-2b4xI:
22.20
5vv5B-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 6 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.46A 6auqA-2b4xI:
undetectable
6auqB-2b4xI:
undetectable		 6auqA-2b4xI:
12.06
6auqB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 6auqA-2b4xI:
undetectable
6auqB-2b4xI:
undetectable		 6auqA-2b4xI:
12.06
6auqB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6aurA-2b4xI:
undetectable
6aurB-2b4xI:
undetectable		 6aurA-2b4xI:
12.06
6aurB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6ausA-2b4xI:
undetectable
6ausB-2b4xI:
undetectable		 6ausA-2b4xI:
12.06
6ausB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 6autA-2b4xI:
undetectable
6autB-2b4xI:
undetectable		 6autA-2b4xI:
12.06
6autB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6auuA-2b4xI:
undetectable
6auuB-2b4xI:
undetectable		 6auuA-2b4xI:
12.06
6auuB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6auuA-2b4xI:
undetectable
6auuB-2b4xI:
undetectable		 6auuA-2b4xI:
12.06
6auuB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6auvA-2b4xI:
undetectable
6auvB-2b4xI:
undetectable		 6auvA-2b4xI:
12.06
6auvB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 6auwA-2b4xI:
undetectable
6auwB-2b4xI:
undetectable		 6auwA-2b4xI:
12.06
6auwB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6auxA-2b4xI:
undetectable
6auxB-2b4xI:
undetectable		 6auxA-2b4xI:
12.06
6auxB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 6auxA-2b4xI:
undetectable
6auxB-2b4xI:
undetectable		 6auxA-2b4xI:
12.06
6auxB-2b4xI:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6auzA-2b4xI:
undetectable
6auzB-2b4xI:
undetectable		 6auzA-2b4xI:
11.08
6auzB-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 6av0A-2b4xI:
undetectable
6av0B-2b4xI:
undetectable		 6av0A-2b4xI:
11.08
6av0B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6av1A-2b4xI:
undetectable
6av1B-2b4xI:
undetectable		 6av1A-2b4xI:
11.08
6av1B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.47A 6av1A-2b4xI:
undetectable
6av1B-2b4xI:
undetectable		 6av1A-2b4xI:
11.08
6av1B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6av2A-2b4xI:
undetectable
6av2B-2b4xI:
undetectable		 6av2A-2b4xI:
11.08
6av2B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6av3A-2b4xI:
undetectable
6av3B-2b4xI:
undetectable		 6av3A-2b4xI:
11.08
6av3B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6av4A-2b4xI:
undetectable
6av4B-2b4xI:
undetectable		 6av4A-2b4xI:
11.08
6av4B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6av4A-2b4xI:
undetectable
6av4B-2b4xI:
undetectable		 6av4A-2b4xI:
11.08
6av4B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.49A 6av5A-2b4xI:
undetectable
6av5B-2b4xI:
undetectable		 6av5A-2b4xI:
11.08
6av5B-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 6cicA-2b4xI:
undetectable
6cicB-2b4xI:
undetectable		 6cicA-2b4xI:
11.08
6cicB-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.49A 6cicA-2b4xI:
undetectable
6cicB-2b4xI:
undetectable		 6cicA-2b4xI:
11.08
6cicB-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 6cidA-2b4xI:
undetectable
6cidB-2b4xI:
undetectable		 6cidA-2b4xI:
11.08
6cidB-2b4xI:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b4x ANTITHROMBIN-III
(Homo
sapiens) 		4 / 7 TRP I 225
PHE I 274
GLU I 378
VAL I 375
 None
 1.48A 6cidA-2b4xI:
undetectable
6cidB-2b4xI:
undetectable		 6cidA-2b4xI:
11.08
6cidB-2b4xI:
11.08