SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b4z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 10 GLY A  24
HIS A  33
HIS A  18
THR A  19
ALA A 101
 None
None
HEM  A 500 (-3.3A)
None
None
 1.40A 1gtnO-2b4zA:
undetectable
1gtnP-2b4zA:
undetectable		 1gtnO-2b4zA:
22.33
1gtnP-2b4zA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 1jffB-2b4zA:
undetectable		 1jffB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 2hxfB-2b4zA:
undetectable		 2hxfB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 2hxhB-2b4zA:
undetectable		 2hxhB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 2p4nB-2b4zA:
undetectable		 2p4nB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 2wbeB-2b4zA:
undetectable		 2wbeB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.21A 3dcoB-2b4zA:
undetectable		 3dcoB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.20A 3edlB-2b4zA:
undetectable		 3edlB-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2b4z CYTOCHROME C
(Bos
taurus) 		5 / 12 GLU A  21
LEU A  68
HIS A  18
LEU A  94
GLY A  34
 None
HEM  A 500 (-4.2A)
HEM  A 500 (-3.3A)
None
None
 1.20A 3iz0B-2b4zA:
undetectable		 3iz0B-2b4zA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2b4z CYTOCHROME C
(Bos
taurus) 		4 / 7 GLU A  62
LEU A  64
GLU A  92
ILE A  95
 None
 0.89A 3s56B-2b4zA:
undetectable		 3s56B-2b4zA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2b4z CYTOCHROME C
(Bos
taurus) 		4 / 5 LYS A  87
ARG A  91
LEU A  94
ASP A  93
 None
 1.30A 4xdtA-2b4zA:
undetectable		 4xdtA-2b4zA:
19.33