SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 TYR X 131
ASP X  46
GLU X  47
PHE X  51
 None
 1.40A 1b2iA-2b5dX:
undetectable		 1b2iA-2b5dX:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		3 / 3 GLU X 425
HIS X 424
ASP X 432
 None
 0.85A 1i9gA-2b5dX:
undetectable		 1i9gA-2b5dX:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 11 LEU X  41
PHE X  45
LEU X  61
LEU X  53
LEU X   9
 None
 1.41A 1mx1B-2b5dX:
undetectable		 1mx1B-2b5dX:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 6 TRP X 246
HIS X 319
TYR X 252
GLY X 254
 None
 1.24A 1mxdA-2b5dX:
4.4		 1mxdA-2b5dX:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 TRP X 246
HIS X 319
TYR X 252
GLY X 254
 None
 1.19A 1mxgA-2b5dX:
4.2		 1mxgA-2b5dX:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 TRP X  29
GLU X  32
LEU X  13
TRP X 356
 None
 1.34A 1q0yH-2b5dX:
undetectable
1q0yL-2b5dX:
undetectable		 1q0yH-2b5dX:
17.52
1q0yL-2b5dX:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 12 ALA X 144
LEU X 149
THR X 141
ILE X 181
LEU X 196
 None
 1.09A 1rg7A-2b5dX:
undetectable		 1rg7A-2b5dX:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 LEU X  70
LEU X  65
SER X  56
TYR X  15
 None
 1.11A 2hc4A-2b5dX:
undetectable		 2hc4A-2b5dX:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 8 HIS X 146
HIS X  10
ALA X 350
LEU X  61
THR X  58
 None
 1.28A 2it4A-2b5dX:
undetectable		 2it4A-2b5dX:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		3 / 3 ARG X 107
THR X  92
VAL X  89
 None
 0.92A 2q64A-2b5dX:
undetectable		 2q64A-2b5dX:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 LEU X  53
LEU X 137
PHE X  45
LEU X 364
 None
 0.86A 2vq5B-2b5dX:
undetectable		 2vq5B-2b5dX:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		3 / 3 SER X  67
GLU X  27
ASP X  69
 None
 0.86A 2zthA-2b5dX:
undetectable		 2zthA-2b5dX:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 12 PHE X 358
GLY X 288
ILE X 285
ASN X 286
ASP X 279
 None
 1.46A 2zznB-2b5dX:
undetectable		 2zznB-2b5dX:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		3 / 3 PRO X  97
LEU X  98
ARG X 293
 None
 0.90A 3aqiA-2b5dX:
undetectable		 3aqiA-2b5dX:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		3 / 3 PRO X 225
PHE X 205
ALA X 382
 None
 0.67A 3itaD-2b5dX:
undetectable		 3itaD-2b5dX:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 10 ASP X 349
PHE X   8
SER X  56
ILE X 181
LEU X 183
 None
 1.46A 3m0wC-2b5dX:
undetectable
3m0wD-2b5dX:
undetectable
3m0wE-2b5dX:
undetectable
3m0wF-2b5dX:
undetectable		 3m0wC-2b5dX:
12.21
3m0wD-2b5dX:
12.21
3m0wE-2b5dX:
12.21
3m0wF-2b5dX:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 8 ASP X 349
PHE X   8
SER X  56
LEU X 183
 None
 1.00A 3m0wE-2b5dX:
undetectable
3m0wF-2b5dX:
undetectable
3m0wG-2b5dX:
undetectable
3m0wH-2b5dX:
undetectable		 3m0wE-2b5dX:
12.21
3m0wF-2b5dX:
12.21
3m0wG-2b5dX:
12.21
3m0wH-2b5dX:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 9 LEU X 183
SER X  56
ILE X 181
PHE X   8
ASP X 349
 None
 1.40A 3m0wC-2b5dX:
undetectable
3m0wD-2b5dX:
undetectable
3m0wE-2b5dX:
undetectable
3m0wF-2b5dX:
undetectable		 3m0wC-2b5dX:
12.21
3m0wD-2b5dX:
12.21
3m0wE-2b5dX:
12.21
3m0wF-2b5dX:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 12 LEU X 505
TYR X 437
LEU X 449
ARG X 447
LEU X 444
 None
 1.00A 3okxB-2b5dX:
undetectable		 3okxB-2b5dX:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 6 GLY X 180
VAL X 167
HIS X 177
THR X 141
 None
 1.12A 3tj7A-2b5dX:
undetectable
3tj7B-2b5dX:
undetectable		 3tj7A-2b5dX:
14.67
3tj7B-2b5dX:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 6 GLY X 180
VAL X 167
HIS X 177
THR X 141
 None
 1.09A 3tj7C-2b5dX:
undetectable
3tj7D-2b5dX:
undetectable		 3tj7C-2b5dX:
14.67
3tj7D-2b5dX:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 8 PHE X 267
ILE X 278
GLY X 288
GLU X  32
 None
 0.92A 4fgjA-2b5dX:
undetectable
4fgjB-2b5dX:
undetectable		 4fgjA-2b5dX:
19.01
4fgjB-2b5dX:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		3 / 3 PRO X 516
ASN X 169
HIS X 173
 None
 0.90A 4ma3H-2b5dX:
0.0
4ma3L-2b5dX:
0.0		 4ma3H-2b5dX:
16.38
4ma3L-2b5dX:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 8 LEU X 137
ILE X   7
PHE X  45
THR X  37
 None
 0.89A 5eseA-2b5dX:
undetectable		 5eseA-2b5dX:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		5 / 7 ASP X 193
LEU X 196
THR X 228
VAL X 206
TYR X 188
 None
 1.41A 5ov9A-2b5dX:
undetectable		 5ov9A-2b5dX:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 4 VAL X 158
VAL X 159
TYR X 152
GLN X 153
 None
 1.25A 5qggA-2b5dX:
undetectable		 5qggA-2b5dX:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 4 VAL X 158
VAL X 159
TYR X 152
GLN X 153
 None
 1.21A 5qgoA-2b5dX:
undetectable		 5qgoA-2b5dX:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 4 VAL X 158
VAL X 159
TYR X 152
GLN X 153
 None
 1.19A 5qgpA-2b5dX:
undetectable		 5qgpA-2b5dX:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 4 VAL X 158
VAL X 159
TYR X 152
GLN X 153
 None
 1.28A 5qgqA-2b5dX:
undetectable		 5qgqA-2b5dX:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 4 VAL X 158
VAL X 159
TYR X 152
GLN X 153
 None
 1.25A 5qhbA-2b5dX:
undetectable		 5qhbA-2b5dX:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 6 ASN X 372
ARG X 366
ILE X  48
GLU X  49
 None
 1.26A 5uigA-2b5dX:
3.6		 5uigA-2b5dX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 LEU X 458
ARG X 480
TYR X 507
GLU X  20
 None
 1.31A 5umwA-2b5dX:
undetectable
5umwF-2b5dX:
undetectable		 5umwA-2b5dX:
9.63
5umwF-2b5dX:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 7 GLN X 244
GLY X 251
TRP X 246
ASP X 322
 None
 0.97A 5vlmE-2b5dX:
1.6		 5vlmE-2b5dX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 5 LEU X  53
PHE X 368
LEU X 364
PHE X 353
 None
 1.05A 5x19C-2b5dX:
3.8
5x19J-2b5dX:
undetectable		 5x19C-2b5dX:
18.95
5x19J-2b5dX:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2b5d ALPHA-AMYLASE
(Thermotoga
maritima) 		4 / 8 LEU X 444
GLU X 509
MET X 504
LEU X 495
 None
 1.23A 6cbzA-2b5dX:
undetectable		 6cbzA-2b5dX:
9.11