SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b5e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 336
ILE A 342
PHE A 311
GLN A 329
 None
 1.15A 2jc9A-2b5eA:
undetectable		 2jc9A-2b5eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  96
ALA A  54
VAL A  34
ILE A  88
 None
 0.83A 3wsjB-2b5eA:
undetectable		 3wsjB-2b5eA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 411
LEU A 412
GLY A 469
SER A 475
 None
 0.93A 4cp3A-2b5eA:
undetectable
4cp3B-2b5eA:
undetectable		 4cp3A-2b5eA:
12.96
4cp3B-2b5eA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 330
LYS A 341
ALA A 334
GLU A 337
PHE A 335
 None
 1.19A 4i1rA-2b5eA:
undetectable		 4i1rA-2b5eA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 313
MET A 307
ASP A 245
 None
 0.79A 4j7xB-2b5eA:
undetectable		 4j7xB-2b5eA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  88
LEU A  53
ILE A 131
PHE A  56
 None
 0.69A 4r38A-2b5eA:
undetectable		 4r38A-2b5eA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  88
LEU A  53
ILE A 131
PHE A  56
 None
 0.68A 4r38D-2b5eA:
undetectable		 4r38D-2b5eA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2b5e PROTEIN
DISULFIDE-ISOMERASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  42
SER A  48
HIS A  49
LEU A  37
 None
 1.02A 5dzke-2b5eA:
undetectable
5dzks-2b5eA:
undetectable		 5dzke-2b5eA:
18.05
5dzks-2b5eA:
0.40