SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		4 / 6 ASP A 654
SER A 653
GLY A 609
GLY A 632
 None
 0.75A 1tnlA-2b5nA:
undetectable		 1tnlA-2b5nA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 536
ILE A 558
LEU A 576
 None
 0.71A 2kceA-2b5nA:
undetectable		 2kceA-2b5nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		4 / 6 ASP A 654
SER A 653
GLY A 609
GLY A 632
 None
 0.78A 2otvA-2b5nA:
undetectable		 2otvA-2b5nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 567
LEU A 616
GLY A 615
PHE A 614
 None
 0.73A 2tsrB-2b5nA:
undetectable		 2tsrB-2b5nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 CYH A 604
PHE A 612
PHE A 614
 None
 0.96A 3cr5X-2b5nA:
undetectable		 3cr5X-2b5nA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 557
ALA A 539
THR A 640
MET A 593
THR A 594
 None
 1.29A 3dl9B-2b5nA:
undetectable		 3dl9B-2b5nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A 471
ILE A 469
VAL A 463
VAL A 426
ARG A 639
 None
 1.25A 3elzC-2b5nA:
undetectable		 3elzC-2b5nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		4 / 7 GLU A 489
ARG A 477
THR A 472
ALA A 474
 None
 0.89A 3mbgA-2b5nA:
undetectable
3mbgB-2b5nA:
undetectable		 3mbgA-2b5nA:
16.00
3mbgB-2b5nA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 673
ILE A 396
GLY A 395
GLY A 393
SER A 653
 None
 1.05A 4fakA-2b5nA:
undetectable		 4fakA-2b5nA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 673
ILE A 396
GLY A 395
GLY A 393
THR A 657
 None
 0.99A 4fakA-2b5nA:
undetectable		 4fakA-2b5nA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 666
ILE A 659
ALA A 651
THR A 636
ALA A 610
 None
 1.00A 5veuB-2b5nA:
undetectable		 5veuB-2b5nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2b5n DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens) 		4 / 7 ALA A 566
ILE A 586
PHE A 612
LEU A 606
 None
 0.80A 6b5vA-2b5nA:
undetectable
6b5vB-2b5nA:
undetectable		 6b5vA-2b5nA:
12.30
6b5vB-2b5nA:
12.30