SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b5o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 LEU A 288
GLY A 261
CYH A 200
ALA A 263
ALA A 184
 None
None
None
FAD  A 403 ( 4.3A)
None
 1.16A 2bm9D-2b5oA:
3.8		 2bm9D-2b5oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 LEU A 288
GLY A 261
CYH A 200
ALA A 263
ALA A 184
 None
None
None
FAD  A 403 ( 4.3A)
None
 1.00A 2br4A-2b5oA:
3.8		 2br4A-2b5oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 LEU A 288
GLY A 261
CYH A 200
ALA A 263
ALA A 184
 None
None
None
FAD  A 403 ( 4.3A)
None
 1.09A 2br4C-2b5oA:
3.8		 2br4C-2b5oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 LEU A 288
GLY A 261
CYH A 200
ALA A 263
ALA A 184
 None
None
None
FAD  A 403 ( 4.3A)
None
 1.09A 2br4D-2b5oA:
3.8		 2br4D-2b5oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 ILE A 262
LEU A 288
GLY A 291
SER A 322
GLN A 325
 None
 1.13A 2ogyB-2b5oA:
undetectable		 2ogyB-2b5oA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 ILE A 262
LEU A 288
GLY A 291
SER A 322
GLN A 325
 None
 1.18A 2ycjA-2b5oA:
undetectable		 2ycjA-2b5oA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 GLY A 361
GLY A 259
ILE A 298
LEU A 288
LEU A 317
 None
 1.06A 2zbpA-2b5oA:
4.3		 2zbpA-2b5oA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		4 / 5 TYR A 342
ALA A 328
ALA A 320
TYR A 334
 None
 1.19A 3d91A-2b5oA:
undetectable		 3d91A-2b5oA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 GLY A 125
ILE A 235
TYR A 156
ALA A 184
SER A 198
 None
 0.99A 3hs6B-2b5oA:
undetectable		 3hs6B-2b5oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		4 / 4 THR A 327
ARG A 338
GLU A 341
VAL A 333
 None
 1.38A 4odoC-2b5oA:
0.0		 4odoC-2b5oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		5 / 12 PHE A 304
PHE A 268
GLY A 361
ALA A 184
VAL A 253
 None
 1.01A 4wnwB-2b5oA:
undetectable		 4wnwB-2b5oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		4 / 7 ILE A 369
PHE A 373
VAL A 335
ILE A 289
 None
 0.96A 4zzbC-2b5oA:
undetectable
4zzbD-2b5oA:
undetectable		 4zzbC-2b5oA:
23.33
4zzbD-2b5oA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		8 / 9 SER A 182
THR A 260
GLY A 261
ALA A 263
CYH A 360
GLY A 361
LEU A 362
GLU A 400
 FAD  A 403 (-3.1A)
FAD  A 403 (-3.2A)
None
FAD  A 403 ( 4.3A)
None
None
None
FAD  A 403 (-3.8A)
 0.48A 5vw4A-2b5oA:
40.9		 5vw4A-2b5oA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		7 / 8 SER A 182
THR A 260
GLY A 261
CYH A 360
GLY A 361
LEU A 362
GLU A 400
 FAD  A 403 (-3.1A)
FAD  A 403 (-3.2A)
None
None
None
None
FAD  A 403 (-3.8A)
 0.52A 5vw5A-2b5oA:
40.7		 5vw5A-2b5oA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2b5o FERREDOXIN--NADP
REDUCTASE
(Synechococcus
sp.
PCC
7002) 		7 / 8 SER A 182
THR A 260
GLY A 261
ALA A 263
CYH A 360
GLY A 361
GLU A 400
 FAD  A 403 (-3.1A)
FAD  A 403 (-3.2A)
None
FAD  A 403 ( 4.3A)
None
None
FAD  A 403 (-3.8A)
 0.48A 5vw9A-2b5oA:
40.8		 5vw9A-2b5oA:
38.71