SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b5u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2b5u COLICIN E3
(Escherichia
coli) 		3 / 3 ARG A 273
THR A 165
VAL A 169
 None
 0.87A 1hxbA-2b5uA:
undetectable		 1hxbA-2b5uA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 12 ILE A 196
VAL A 185
ALA A 121
GLY A  91
TYR A 137
 None
 1.09A 1kiaA-2b5uA:
undetectable		 1kiaA-2b5uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 12 ILE A 196
VAL A 185
ALA A 121
GLY A  91
TYR A 137
 None
 1.08A 1kiaB-2b5uA:
undetectable		 1kiaB-2b5uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 12 ILE A 196
VAL A 185
ALA A 121
GLY A  91
TYR A 137
 None
 1.08A 1kiaC-2b5uA:
undetectable		 1kiaC-2b5uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 12 ILE A 196
VAL A 185
ALA A 121
GLY A  91
TYR A 137
 None
 1.06A 1nbhB-2b5uA:
undetectable		 1nbhB-2b5uA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2b5u COLICIN E3
(Escherichia
coli) 		4 / 8 VAL A 287
ASP A 187
PRO A 228
LEU A 230
 None
 1.01A 1z2bB-2b5uA:
undetectable		 1z2bB-2b5uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 11 GLU A 515
GLY A 514
PRO A 468
TYR A 507
PHE A 530
 None
 1.42A 2h21B-2b5uA:
2.7		 2h21B-2b5uA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 11 THR A 267
VAL A 287
ILE A 155
ASN A 195
ILE A 196
 None
 1.24A 3kpcA-2b5uA:
undetectable		 3kpcA-2b5uA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2b5u COLICIN E3
(Escherichia
coli) 		4 / 8 ASN A 322
ALA A 319
PRO A 315
LEU A 446
 None
 0.87A 4jjkA-2b5uA:
undetectable		 4jjkA-2b5uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 8 ALA A 115
ALA A 117
ILE A 116
PHE A  90
LEU A 159
 None
 1.43A 4v1fA-2b5uA:
6.2
4v1fB-2b5uA:
6.1		 4v1fA-2b5uA:
10.24
4v1fB-2b5uA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2b5u COLICIN E3
(Escherichia
coli) 		5 / 10 ALA A 211
ILE A 272
PHE A 220
GLY A 279
ALA A 282
 None
 1.08A 5ajqB-2b5uA:
undetectable		 5ajqB-2b5uA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2b5u COLICIN E3
(Escherichia
coli) 		3 / 3 SER A 529
HIS A 526
TYR A 519
 None
 1.05A 5y2tA-2b5uA:
undetectable		 5y2tA-2b5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 2b5u COLICIN E3
(Escherichia
coli) 		3 / 3 LYS A 154
VAL A 287
ASP A 289
 None
 0.61A 6fgdA-2b5uA:
undetectable		 6fgdA-2b5uA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2b5u COLICIN E3
(Escherichia
coli) 		4 / 4 ARG A 306
GLU A 302
GLU A 309
ARG A 305
 None
 1.31A 6fk2A-2b5uA:
undetectable		 6fk2A-2b5uA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2b5u COLICIN E3
(Escherichia
coli) 		3 / 3 PHE A 375
ARG A 377
GLN A 374
 None
 1.16A 6g1pB-2b5uA:
undetectable		 6g1pB-2b5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2b5u COLICIN E3
(Escherichia
coli) 		4 / 8 ASP A 531
HIS A 526
GLU A 517
ASP A 510
 None
 1.28A 6mn4B-2b5uA:
undetectable		 6mn4B-2b5uA:
19.66