SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		3 / 3 SER A 150
THR A  28
GLN A 146
 None
 0.81A 2fk8A-2b67A:
undetectable		 2fk8A-2b67A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 181
ASP A  25
ASP A 145
 None
 0.72A 4a6eA-2b67A:
undetectable		 4a6eA-2b67A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A   6
ALA A 142
ALA A  29
ILE A  76
VAL A 179
 None
 1.11A 4h1nA-2b67A:
undetectable		 4h1nA-2b67A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 179
ILE A  76
ILE A 148
GLY A 147
LEU A   6
 None
 0.97A 4y8wC-2b67A:
undetectable		 4y8wC-2b67A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		5 / 7 PRO A  23
VAL A  26
ILE A  30
PHE A  47
VAL A  49
 None
 0.59A 5bmvC-2b67A:
undetectable		 5bmvC-2b67A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A 157
VAL A 164
LEU A  57
 None
 0.53A 5e5jB-2b67A:
undetectable		 5e5jB-2b67A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A  76
ALA A  77
GLY A 180
LEU A  57
VAL A  26
 None
 0.98A 5i71A-2b67A:
undetectable		 5i71A-2b67A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2b67 COG0778:
NITROREDUCTASE
(Streptococcus
pneumoniae) 		5 / 12 PRO A  23
VAL A  26
ILE A  30
PHE A  47
VAL A  49
 None
 0.51A 5j2tC-2b67A:
undetectable		 5j2tC-2b67A:
20.27