SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 2b6c HYPOTHETICAL PROTEIN
EF3068
(Enterococcus
faecalis) 		3 / 3 ALA A  76
VAL A  80
TRP A 114
 None
 0.96A 1w5uA-2b6cA:
undetectable
1w5uB-2b6cA:
undetectable		 1w5uA-2b6cA:
7.10
1w5uB-2b6cA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2b6c HYPOTHETICAL PROTEIN
EF3068
(Enterococcus
faecalis) 		4 / 7 SER A 113
VAL A 115
VAL A  80
TRP A 114
 None
 0.81A 3n61A-2b6cA:
undetectable
3n61B-2b6cA:
undetectable		 3n61A-2b6cA:
19.15
3n61B-2b6cA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2b6c HYPOTHETICAL PROTEIN
EF3068
(Enterococcus
faecalis) 		4 / 8 SER A 113
VAL A 115
VAL A  80
TRP A 114
 None
 0.85A 3nlrA-2b6cA:
undetectable
3nlrB-2b6cA:
undetectable		 3nlrA-2b6cA:
19.15
3nlrB-2b6cA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2b6c HYPOTHETICAL PROTEIN
EF3068
(Enterococcus
faecalis) 		3 / 3 LYS A 210
TYR A 211
ARG A 181
 None
 1.43A 4gc9A-2b6cA:
undetectable		 4gc9A-2b6cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2b6c HYPOTHETICAL PROTEIN
EF3068
(Enterococcus
faecalis) 		5 / 9 LEU A 119
LEU A  85
THR A 124
LEU A 122
ILE A 125
 None
 1.33A 4ubsA-2b6cA:
undetectable		 4ubsA-2b6cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2b6c HYPOTHETICAL PROTEIN
EF3068
(Enterococcus
faecalis) 		4 / 5 ARG A 138
ALA A 160
GLN A 173
ILE A 176
 None
 1.37A 6g9bA-2b6cA:
undetectable
6g9bB-2b6cA:
undetectable		 6g9bA-2b6cA:
15.94
6g9bB-2b6cA:
17.51