SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 TYR A 213
TRP A 212
VAL A  95
GLY A 100
GLY A 102
 None
 0.96A 1etrH-2b6nA:
undetectable		 1etrH-2b6nA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		4 / 4 SER A  80
PHE A  49
GLU A  48
GLY A  75
 None
 1.46A 1icvA-2b6nA:
0.0
1icvB-2b6nA:
0.0		 1icvA-2b6nA:
20.75
1icvB-2b6nA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 ILE A  10
GLY A  78
ALA A  53
SER A 211
HIS A  46
 None
 1.35A 1nbhA-2b6nA:
2.7		 1nbhA-2b6nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 ILE A  10
GLY A  78
ALA A  53
SER A 211
HIS A  46
 None
 1.35A 1nbhC-2b6nA:
undetectable		 1nbhC-2b6nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 ILE A  10
GLY A  78
ALA A  53
SER A 211
HIS A  46
 None
 1.35A 1nbhD-2b6nA:
undetectable		 1nbhD-2b6nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		3 / 3 LYS A 260
ASP A  21
ASN A  17
 None
CA  A 300 (-3.1A)
None
 1.00A 2bm9A-2b6nA:
2.3		 2bm9A-2b6nA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 8 GLY A 136
GLY A 135
GLY A 134
SER A 138
THR A 141
 None
 1.41A 3d41A-2b6nA:
undetectable		 3d41A-2b6nA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 SER A 211
GLY A  41
GLY A  70
LEU A  43
VAL A  90
 None
 1.24A 3fzgA-2b6nA:
undetectable		 3fzgA-2b6nA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 ILE A  77
GLY A  78
GLY A  79
ALA A  53
VAL A  90
 None
 0.85A 3jb2A-2b6nA:
undetectable		 3jb2A-2b6nA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 VAL A 128
PRO A 126
ALA A 246
LEU A 252
ILE A 178
 None
 1.02A 3ku1H-2b6nA:
2.4		 3ku1H-2b6nA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 VAL A 157
ALA A 234
LEU A 272
THR A 249
LEU A 252
 None
 1.19A 3mteA-2b6nA:
undetectable		 3mteA-2b6nA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		3 / 3 GLY A 135
ILE A 108
VAL A 107
 None
 0.49A 3nv6A-2b6nA:
undetectable		 3nv6A-2b6nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 11 VAL A  73
ALA A  74
GLY A  75
TYR A  82
TYR A 213
 None
 1.49A 3qxyB-2b6nA:
undetectable
3qxyQ-2b6nA:
undetectable		 3qxyB-2b6nA:
20.18
3qxyQ-2b6nA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		4 / 5 ILE A 201
ALA A 256
HIS A 229
ARG A  12
 None
 1.08A 4acaB-2b6nA:
3.9
4acaC-2b6nA:
3.7		 4acaB-2b6nA:
20.13
4acaC-2b6nA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLY A 232
ALA A 231
VAL A 156
LEU A 252
ILE A  13
 None
 1.19A 4pd5A-2b6nA:
undetectable		 4pd5A-2b6nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLY A 232
ALA A 231
VAL A 156
LEU A 252
ILE A  13
 None
 1.21A 4pd9A-2b6nA:
undetectable		 4pd9A-2b6nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLY A 181
ILE A  13
THR A  76
VAL A  73
THR A 249
 None
 1.00A 4q5mA-2b6nA:
undetectable		 4q5mA-2b6nA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		4 / 8 SER A 193
THR A 183
SER A 206
ASP A 187
 None
None
SO4  A 301 (-2.5A)
None
 1.40A 4qb9D-2b6nA:
undetectable		 4qb9D-2b6nA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 9 ALA A  53
ILE A  38
GLY A  41
SER A 211
VAL A  73
 None
 1.06A 4r20B-2b6nA:
undetectable		 4r20B-2b6nA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 SER A 210
ILE A  10
ASP A  21
GLN A  15
ILE A  13
 None
None
CA  A 300 (-3.1A)
CA  A 300 (-3.5A)
None
 1.37A 4uroA-2b6nA:
undetectable		 4uroA-2b6nA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 SER A 210
ILE A  10
ASP A  21
GLN A  15
ILE A  13
 None
None
CA  A 300 (-3.1A)
CA  A 300 (-3.5A)
None
 1.33A 4uroB-2b6nA:
undetectable		 4uroB-2b6nA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		4 / 7 LEU A 133
THR A 179
ALA A 158
THR A 223
 None
 1.03A 5bojB-2b6nA:
undetectable		 5bojB-2b6nA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLY A  79
ILE A  60
GLY A 102
GLY A 100
THR A  76
 None
 1.02A 5eqbA-2b6nA:
undetectable		 5eqbA-2b6nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		4 / 8 ARG A  52
ALA A  35
VAL A 128
GLY A 232
 None
 0.99A 5v0vA-2b6nA:
undetectable		 5v0vA-2b6nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLU A  48
VAL A  37
VAL A  90
GLY A  78
SER A  80
 None
 1.03A 5vopA-2b6nA:
undetectable		 5vopA-2b6nA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLY A  79
GLY A  78
VAL A  90
PRO A 228
GLY A 232
 None
 0.95A 6gneA-2b6nA:
4.2		 6gneA-2b6nA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 2b6n PROTEINASE K
(Serratia
sp.
GF96) 		5 / 12 GLY A  79
GLY A  78
VAL A  90
PRO A 228
GLY A 232
 None
 0.95A 6gneB-2b6nA:
4.6		 6gneB-2b6nA:
18.02