SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2b6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		4 / 8 TYR A 204
PHE A 198
THR A 195
LEU A 118
 None
 1.20A 1ea1A-2b6oA:
undetectable		 1ea1A-2b6oA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		6 / 10 PHE A  26
GLY A  96
GLY A  27
LEU A  28
LEU A 104
ALA A 101
 None
 1.32A 2v3kA-2b6oA:
undetectable		 2v3kA-2b6oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		3 / 3 HIS A 172
MET A 176
MET A 183
 None
 1.37A 2vj1A-2b6oA:
undetectable		 2vj1A-2b6oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		4 / 4 VAL A 103
ARG A 187
ILE A 193
THR A 108
 MC3  A 265 (-4.1A)
None
MC3  A 270 (-4.0A)
None
 1.25A 3cl9A-2b6oA:
undetectable		 3cl9A-2b6oA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 ASN A 184
ALA A  19
ALA A  99
VAL A 103
THR A  54
 None
None
MC3  A 270 ( 3.7A)
MC3  A 265 (-4.1A)
None
 1.16A 3czhB-2b6oA:
undetectable		 3czhB-2b6oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		4 / 6 VAL A  90
LEU A  28
ALA A 186
LEU A  94
 MC3  A 266 (-4.8A)
None
None
MC3  A 266 (-4.6A)
 0.88A 3kk6B-2b6oA:
undetectable		 3kk6B-2b6oA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		3 / 3 ASN A 184
ASN A 119
GLU A 134
 None
 0.89A 3kpdB-2b6oA:
undetectable		 3kpdB-2b6oA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 11 THR A 138
LEU A 168
TYR A  23
VAL A  67
PHE A 141
 None
 1.49A 4lhmA-2b6oA:
undetectable		 4lhmA-2b6oA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 VAL A  90
GLN A  93
LEU A  52
ALA A 186
ASN A 184
 MC3  A 266 (-4.8A)
None
None
None
None
 1.14A 4qckA-2b6oA:
undetectable		 4qckA-2b6oA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 ALA A 117
SER A  31
GLY A  27
GLU A 134
TYR A 204
 None
 1.21A 4r29B-2b6oA:
1.2		 4r29B-2b6oA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 10 ASP A 150
ALA A  74
TYR A 219
PHE A  75
GLY A  78
 None
 1.31A 4xp1A-2b6oA:
undetectable		 4xp1A-2b6oA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 ALA A  97
PRO A  69
THR A 138
GLY A 182
THR A 179
 None
 1.39A 5hfjC-2b6oA:
undetectable		 5hfjC-2b6oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 ALA A  97
PRO A  69
THR A 138
GLY A 182
THR A 179
 None
 1.29A 5hfjG-2b6oA:
undetectable		 5hfjG-2b6oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2b6o LENS FIBER MAJOR
INTRINSIC PROTEIN
(Ovis
aries) 		5 / 12 ALA A 190
PRO A  69
THR A 138
GLY A 182
THR A 179
 None
 1.38A 5hfjG-2b6oA:
undetectable		 5hfjG-2b6oA:
21.07